Estrone sulphate

Hong J-S, Tilson HA, Yoshikawa K Effects of lithium and haloperidol administration on the rat brain levels of Substance P. J Pharmacol Exp Ther 224 590-597, 1983 Honig A, Bartlett JR, Bouras N, et al Amino acid levels in depression a preliminary investigation. J Psychiatr Res 22 159-164, 1989 Honjo H, Ogino Y, Natitoh K, et al In vivo effects by estrone sulphate on the central nervous system on senile dementia [Alzheimer s type). Journal of Steroid Biochemistry 34 521-525, 1989... 

Pentafluorophenylhydrazones permit up to 0.1 ng of estrone to be determined with the ECD [381 ]. A hydroxyl group in position 3 is blocked by methylation with dimethyl sulphate and the reaction with pentafluorophenylhydrazine is performed in methanol in the presence of acetic acid. A column packed with 1% of XE-60 on Gas-Chrom Q at 205°C is suitable for the analysis. The determination of free estrone in blood plasma by this procedure provides good results provided that the measurement is corrected for the total recovery. 

Approx 30 2-hydroxylation (CYP3A4) and sulphate and glucuronide conjugation and up to 30% is excreted unoxidized. Excretion is 60% renal and 40% in faeces. High first pass metabolism Estrone (small amounts)... 

SYNS CONESTORAL ESTRA-1,3,5(10)-TRIEN-17-ONE, 3-(SULFOXYl-, SODIUM SALT (9CI) ESTRONE, HYDROGEN SULFATE, SODIUM SALT ESTRONE SULFATE SODIUM ESTRONE SULFATE SODIUM SALT ESTRONE-3-SULFATE SODIUM SALT EVEX MORESTIN OESTRONE-3-SULPHATE SODIUM SALT SODIUM ESTRONE SULFATE SODIUM ESTRONE-3-SULFATE... 

Importantly, these hormones including estradiol dehydrogenase are chiefly metabolized in the liver and mostly get excreted as water-soluble glucuronide and sulphate conjugates. Estrone is regarded as a less active (1/12) metabolite of estradiol. 

---