Selective immune tolerance

SDS PAGE, see electrophoresis Selective immune tolerance, 7 Semi-dry blotting, 236 Sepharose, 33, 274 Sequential epitope, 256 Serum, 35... 

ACAID Anterior chamber-associated immune deviation-a unique form of immune tolerance. ACAID is a selective, systemic immune deficiency where Antigen-specific delayed hypersensitivity and complement-fixing antibody responses are impaired by lymphocyte responses while other immune effectors are left preserved. 

Because immunotherapy is expensive, has potential risks, and requires a major time commitment from patients, it should only be considered in select patients. Good candidates include patients who have a strong history of severe symptoms unsuccessfully controlled by avoidance and pharmacotherapy and patients who have been unable to tolerate the adverse effects of drug therapy. Poor candidates include patients with medical conditions that would compromise the ability to tolerate an anaphylactic-type reaction, patients with impaired immune systems, and patients with a history of nonadherence to therapy. 

In summary, therefore, the ability to tolerate dietary exposure to food proteins does not demand the suppression of all immune responses, but rather the avoidance or selective inhibition of immune responses of the quality required for IgE antibody production and allergic sensitization. Against this background an intriguing question relates to the nature of factors that influence the loss or failure of immunological tolerance and acquisition of allergic sensitization to food proteins, and which underlie inter-individual differences in susceptibility to food allergy [43],... 

Although central tolerance is the major mechanism to establish the T-cell repertoire by positive and negative selection mechanisms, thymic deletion of harmful T-cell populations is incomplete. Therefore, the immune system has developed mechanisms that deal with tolerance in the peripheral lymphoid organs providing the necessary... 

It is noteworthy that MHC class I downregulation is not the only escape mechanism available for tumors to avoid T cell responses other mechanisms such as downregulation of the tumor antigens, alterations of the apoptosis program, expression of inhibitory molecules, lack of expression of costimulatory molecules leading to immunological tolerance have been also described. The identification of defined immune escape mechanisms in human or mouse tumors point to the existence of active immunosurveillance which is important for the implementation T cell-based immunotherapy protocols. This information will further help to select patients suitable for such therapies. Furthermore, restoration of the tumor MHC class I phenotype to a normal MHC phenotype may be an other strategy to restore an efficient immune response in cancer patients. All these approaches are still hypothetical and no clinical procedures have been tested so far. 

Abstract Alkaloids are a special group of secondary compounds and are part of an organism s adaptation mechanism to its living environment. They are not toxic when stored, but become toxic as a result of cell pH change. The defensive function of alkaloids is only secondary, and connected to internal immune and regulation processes. Animal responses to alkaloids are very diverse. Some animals can tolerate alkaloids relatively well, while others are harmed or even poisoned by them. Animal behaviour in relation to alkaloids depends on evolutionary and co-evolutionary factors. Sequestration of alkaloids is connected with these processes. Alkaloids are a part of plant-derived nutrition. A selective toxicity of these compounds in vertebrates is clearly observed. Vertebrates have the capacity to recognize alkaloids. 

Klinman, N.R. (1996). The clonal selection hypothesis and current concepts of B cell tolerance. Immunity 5, 189-195. 

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