Salmonella vaccine

S. B. Svenson, M. Nurminen, and A. A. Lindberg, Artificial Salmonella vaccines O-Antigenic oligosaccharide-protein conjugates induce protection against infection with Salmonella typhimurium, Infect Immun., 25 (1979) 863-872. 

Nayak, A. R., Tinge, S. A., Tart, R. C., McDaniel, L. S., and Briles, D. E., 3rd, and Curtiss, R. (1998), A live recombinant avirulent oral Salmonella vaccine expressing pneumococcal surface protein A induces protective responses against Streptococcus pneumoniae, Infect. Immun., 66,3744—3751. 

Nakayamma, K. Kelly, S.M. Curtiss, R., III. Construction of an ASD-I- expression-cloning vector stable maintenance and high level expression of cloned genes in a salmonella vaccine strain. Biotechnology 1998, 6, 693-697. 

Live vectors (131,133) are another appHcation of genetic engineering. In this case, the genes from a pathogen are inserted into a vaccine vector, such as salmonella or vaccinia. In the case of salmonella, it will be possible to develop an oral vaccine. Vectors for this appHcation include salmoneUa, BCG, poHo, adenovims, and vaccinia. 

Killing. The proeess by which the live bacteria in the culture are killed and thus rendered harmless. Heat and disinfectants are employed. Heat and/or formalin are required to kill the cells of Bordetella pertussis used to make whooping-cough vaccines, and phenol is used to kill the Vibrio cholerae in cholera vaccine and the Salmonella typhi in typhoid vaeeine. 

Because patient with SCD have impaired splenic function, they are less adequately protected against encapsulated organisms such as S. pneumoniae, Hemophilus influenzae, and Salmonella. The use of pneumococcal vaccine in SCD patients has decreased the rates of morbidity and mortality dramatically. However, there are still groups of SCD children who continue to have high rates of invasive pneumococcal infections.17 Two pneumococcal vaccines are available. The 7-valent conjugate... 

Direct determination of Salmonella live-vaccine strains 220... 

Clegg, S., and Swenson, D. L. (1994). Salmonella fimbriae. In "Fimbriae Adhesion, Genetics Biogenesis, and Vaccines" (P. Klemm, ed.), pp. 105-113. CRC Press Inc, Boca Raton. 

Examples of killed or inactivated vaccines are cholera vaccine containing dead strains of Vibrio cholerae, hepatitis A vaccine with inactivated hepatitis A virus, pertussis vaccine with killed strains of Bordetella pertussis, typhoid vaccine with killed Salmonella typhi, and influenza vaccine with various strains of inactivated influenza viruses (see Exhibit 4.2 for a discussion of influenza viruses and vaccines and Exhibit 4.3 on avian influenza H5N1). 

Jason Kindrachuk is a postdoctoral fellow at the University of British Columbia (UBC) in the laboratory of Professor R. E. W. Hancock. Jason received his Ph.D. from the University of Saskatchewan in 2007 where his research focused on host and pathogen sensory systems. During his study he specially focused on TLR-9 receptor—ligand interactions and the interactions between host defense peptides and the PhoPQ two-component sensory system of Salmonella typhimurium. In 2008 Jason received the Canadian Cystic Fibrosis Foundation Kin Canada Fellowship for his research in the area of alternative therapies for treatment of antibiotic- and multidrug-resistant bacteria. Currently his research is focused on the investigation of structure-activity relationships amongst natural and synthetic host defense peptides from the perspective of associated immunomodulatory activities and as well as vaccine formulation strategies. 

Typhoid vaccines Killed Salmonella typhi Active immunization against typhoid fever... 

Recombinant vaccines Vaccines that can deliver and penetrate intestinal wall via M cells Tetanus toxin, Salmonella strains, vaccinia virus vector... 

Thyrotopin alia, thyroid stimulating hormone (TSH), human recombinant, produced in CHO cells Vivotif Berna Typhoid vaccine/Swiss [BIO] Typhoid vaccine live oral Ty21a [FDA] Salmonella typhi vaccine [SY] Vaccinum Febris Typhoidis Vivum Perorale (Stirpe Ty 21a) [SY Latin] Ty21a typhoid vaccine [SY] Typhoral [TR in Germany] NDC 58337-0003-01 [NDC]... 

Therapeutic vaccines were tested in BALB/c mice bearing TA3-Ha mammary carcinoma. The treatment consisted of 4 subcutaneous injections, at 3-6 days intervals, of Detox [a commercial preparation of cell wall skeletons from Mycobacterium phlei and non-toxic monophosphoryl lipid A from Salmonella minnesota (S. minnesota) in squalane oil and Tween 80 from Ribi Immunochemical research, Montana, USA] mixed with Thomsen-Friedenreich (TF) antigen coupled with KLH (Keyhole Limpet Hemocyanin) performed 5 days after the tumor cell injection. This vaccination achieved the survival of 25 % of the mice. Pretreatment of mice with cyclophosphamide in order to inhibit any suppressive response, increased survival to 50 % when the treatment began 5 days after tumor cell injection, and to 90 % when the treatment began 2 days after tumor cell injection. Both antibody as well as delayed-... 

Khan, C.M., Villarreal-Ramos, B., Pierce, R.J., Demarco de Hormaeche, R., McNeill, H., Ali, T., Chatfield, S., Capron, A., Dougan, G. and Hormaeche, C.E. (1994a) Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the p28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella. The Journal of Immunology 153, 5634-5642. 

D. C. Watson, J. B. Robbins, and S. C. Szu, Protection of mice against Salmonella typhimurium with an O-specific polysaccharide-protein conjugate vaccine, Infect Immun., 60 (1992) 4679-4686. 

C Coynault, V Robbe-Saule, F Norel. Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (0s) regulon. Mol Microbiol 22 149-160, 1996. 

Promegestone Propfol injection Propoxur + flumethrin Purified chick embryo cell tissue Purified vicapsular polysaccharide of salmonella typhi Rabbit Antihuman thymocyte immunoglobulin intravenous Rabies vaccine inactivated (Vero-Cell)... 

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