Salmonella infections vaccination against

Because patient with SCD have impaired splenic function, they are less adequately protected against encapsulated organisms such as S. pneumoniae, Hemophilus influenzae, and Salmonella. The use of pneumococcal vaccine in SCD patients has decreased the rates of morbidity and mortality dramatically. However, there are still groups of SCD children who continue to have high rates of invasive pneumococcal infections.17 Two pneumococcal vaccines are available. The 7-valent conjugate... 

S. B. Svenson, M. Nurminen, and A. A. Lindberg, Artificial Salmonella vaccines O-Antigenic oligosaccharide-protein conjugates induce protection against infection with Salmonella typhimurium, Infect Immun., 25 (1979) 863-872. 

D. C. Watson, J. B. Robbins, and S. C. Szu, Protection of mice against Salmonella typhimurium with an O-specific polysaccharide-protein conjugate vaccine, Infect Immun., 60 (1992) 4679-4686. 

Nayak, A. R., Tinge, S. A., Tart, R. C., McDaniel, L. S., and Briles, D. E., 3rd, and Curtiss, R. (1998), A live recombinant avirulent oral Salmonella vaccine expressing pneumococcal surface protein A induces protective responses against Streptococcus pneumoniae, Infect. Immun., 66,3744—3751. 

---