Safety acceptable level

Since the resources for data collection systems will be provided by senior management it is essential that information from the system is fed back to policy makers at this level. It is also important that the system indicates the problem areas as well as the successes. Many organizations have drifted to a state where safety standards have fallen to below acceptable levels over time as a result of suppression of information feedback to senior managers. This may be carried out with good intentions, but its long-term effect can be disastrous. 

For new sites with 50 tons or more of LPG the Control of Major Accident Hazards Regulations 1984 apply. For sites which will have 300 tons or more (shortly to be reduced to 200 tons or more) these Regulations impose additional duties on site operators which include the prior submission of a safety report . This report has to set out the potential hazards of the plant and the means by which the risks are reduced to an acceptable level. The LPGITA has produced a Guide to the Writing of LPG Safety Reports which supplements the general guidance in the HSE booklet HS(R)21. 

Noise can constitute a danger to health, and therefore adequate precautions must be taken to protect personnel who are required to be in such an environment. The Health and Safety at Work, etc. Act 1974 has the power to control noise emissions, but the subject is complex. If it is anticipated that noise will exceed acceptable levels then... 

The EU will accept applications without supporting pre-clinical and clinical data, if it can be demonstrated that the active substances have been in well-established medical use in the Community for at least 10 years, with recognised efficacy and an acceptable level of safety. This route would be appropriate for many common over-the-counter (OTC) products. Safety and efficacy is supported by providing copies of published scientific literature as part of the submission that is, the submission relies on safety and efficacy data available in the public domain, as opposed to confidential data from authorised applications that is the cornerstone of generic applications. 

Costs associated with increased government regulation are also difficult to quantify. Public concern in response to chemical release accidents affects regulators and community policy groups. It is evident that the U.S. chemical industry is already spending large amounts of money to avoid accidents and to deal with their consequences when they occur these costs are borne in part by the consumers. Continued expenditures are likely as industry strives to achieve an "acceptable" level of public safety throughout all chemical industry operations. 

False. Fireworks do cause a large number of fires and injury accidents every year. However, if the user follows the Firework Code it is possible to enjoy them with an acceptable level of safety. A non-safety argument for banning them could be made on the grounds that their use often frightens animals and annoys nearby residents. 

The ability of a rubber compound to meet the requirements of processing, i.e., to cope with the day-to-day variations in ambient temperature, in temperature of cooling water, in amount of uncured waste available, etc., while still maintaining an acceptable level of product quality. See Processing Safety. 

The manner in which toxicological knowledge must work together with the knowledge of human behavior, fire dynamics, and chemistry to produce an acceptable level of fire safety is proposed. A hypothetical example illustrates what must be done with adequate accuracy in order to design fire safety to a performance code. The example may give the impression that this can already be done. In fact, each computer code used contains dozens of assumptions, some very crude, so that the accuracy of present predictions are unacceptably low. 

There are three safety integrity levels (SILs) that are generally accepted in the chemical process industry for emergency shutdown systems ... 

To achieve an economical electrical installation which will provide an acceptable level of safety at the lowest possible cost. 

Safety - A general term denoting an acceptable level of risk of, relative freedom from and low probability of harm. 

Detailed references in published scientific literature are sufficient to demonstrate that the constituents of the product have a well-established medicinal use, with recognised efficacy and an acceptable level of safety or... 

In summary, LC-MS offers excellent sensitivity for many classes of pharmaceutical compounds. Due to the fact that MS is becoming more routine (i.e., it is essentially another detector), LC-MS should be the first consideration for all cleaning verification assays that are less than 0.1 pg/swab. In the citations outlined above, LC-MS has been shown to offer excellent sensitivity and specificity for the analytes of interest. The mass spectrometric conditions can be optimized in a flow injection mode to allow for rapid method development. All LC-MS analytical methods were validated in a way consistent with the requirements outlined in Table 15.3. The applications cited utilized LC-MS because of the sensitivity requirements of the safety acceptance limits however, if the molecule of interest poses unique detection challenges such as a poor chromophote, LC-MS should be considered for assays at the level of 1.0 ig/unit area, or less. Above 1.0 xg/unit area there may be more attractive options for these swab determinations. 

But at the same time the regulation drafters are faced with the still more difficult job of doing a risk evaluation. That is, they must recommend public policy decisions as to the acceptable levels of risks for a variety of hazardous waste activities, e.g., acceptable minimums for the efficiency of destruction of hazardous wastes by incineration. In principle, this process may be not unlike the decisions made by a banker about a potential loan, or an insurance underwriter in setting the rate for an insurance policy a risk assessment is made, and an appropriate safety margin is factored into the interest rate or the policy premium to arrive at an acceptable level of risk for the individual case (but based on experience and projections for a large number of cases). 

Toxicology studies are conducted to define the safety profile of a candidate and include definition of the no-toxic-effect dose, MTD, potential organs of toxicity, and potential biochemical markers to detect and track toxic events. Most developmental compounds that do not become therapeutic products have unacceptable toxicity in animals or humans. Before the definitive toxicology studies needed to support an IND submission are initiated, a number of animal experiments can be conducted to characterize the potential toxicity of the candidate. These early toxicology evaluations are usually conducted in the same species as used in pharmacology evaluations. As mentioned earlier, the lowest dose that has no toxicity or an acceptable level of toxicity is compared with the dose that gives the desired pharmacologic response in the same animal species to obtain a therapeutic ratio or index for that species. 

Acrylics are combustible plastics, and the fire precautions normally used with other combustibles must be observed in handling, storing, and using them. The fire hazards of acrylic installations can be kept within acceptable levels by complying with building codes, applicable Underwriters Laboratories standards, and the established principles of Fire safety. 

Schedule I—The drug has a high potential for abuse, is not currently accepted for medical use in treatment in the United States, and lacks accepted levels of safety for use under medical supervision. 

In view of the catastrophic effects and the increasingly severe legal and economic implications of a disastrous explosion, a large amount of effort is devoted to the safety of operations, while keeping control costs at an acceptable level. This work has been given increased impetus in the United States by the military plant modernization now underway and the development of a variety of new or improved processes for making explosives. 

Molecular theories are fundamental in assisting material producers to develop more ESC-resistant materials. However, where load-bearing structures are concerned, an engineering approach to ESC capable of setting up suitable design criteria is required. This should result in the safety of the structure being at an acceptable level with reasonable confidence. Such criteria make use of fracture mechanics and its critical stress intensity factor paramenter, Kic. 

Generic studies of geologic disposal conducted by the Swedish KBS, the Commission of European Communities (CEC), and others have concluded that geologic disposal systems can achieve an acceptable level of safety to protect future generations from the radiological hazards associated with these wastes. 

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