Role of Reactive Oxygen Species

Ranadive, N.S. and Menon, I.A. (1986). Role of reactive oxygen species and free radicals from melanins in photoin-duced cutaneous inflammation. Pathol. Immunopathol. Res. 5, 118-139. 

Van der Vliet, A. and Bast, A. (1992). Role of reactive oxygen species in intestinal diseases. Free Rad. Biol. Med. 12, 499-513. 

Flowers, L. Ohnishi, T. Penning, T. M. DNA strand scission by polycylic hydrocarbon o-quinone role of reactive oxygen species, Cu(II)/(I) redox cycling, and o-semiquinone anion radicals. Biochemistry 1997, 36, 8640-8648. 

The above data suggest an important role of reactive oxygen species in the development of heart diseases. This suggestion has been supported by many studies, which also demonstrated a potential efficacy of antioxidants, free scavengers, and chelators in the treatment of these diseases. Mitochondrial oxygen radical overproduction can probably be one of the critical causes. 

Hei, T.K., Liu, S.U.X. and Waldren, C. (1998) Mutagenicity of arsenic in mammalian cells role of reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America, 95(14), 8103-7. 

Sontakke, A.N. and Tare, R.S. 2002. A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin. Chim. Acta 318, 145-148. 

Flora, S.J.S., Saxena, G., Mehta, A. (2007c). Reversal of lead-induced neuronal apoptosis by chelation treatment in rats role of reactive oxygen species and intracellular Ca. J. Pharmacol. Exp. Ther. 322 108-16. 

Broaddus VC, Yang L, Scavo LM, et al. 1997. Crocidolite asbestos induces apoptosis of pleural mesothelial cells Role of reactive oxygen species and poly (ADP-ribosyl) polymerase. Environ Health Perspect Suppl 105 1147-1152. 

Simeonova PP, Toriumi W, Kommineni C, et al. 1997. Molecular regulation of IL-6 activation by asbestos in lung epithelial cells Role of reactive oxygen species. J Immimol 159 3921-3928. 

V.P. Skulachev, Possible role of reactive oxygen species in the antiviral defence, Biochem. (Moscow) 63 (1998) 1438-1440. 

Casillas AM, Hiura T, Li N, Nel AE. Enhancement of allergic inflammation by diesel exhaust particles permissive role of reactive oxygen species. Ann Asthma Allergy Immunol 83(6) 624—629, 1999. 

Gamaley, LA. and Klyubin, I.V. (1999). Roles of reactive oxygen species signaling and regulation of cellular functions. Int Rev Cytol 188, 203-55. 

Kimura, H., Sawada, T., Oshima, S., Kozawa, K., Ishioka, T., and Kato, M. (2005). Toxicity and roles of reactive oxygen species. Curr Drug Targets Inflamm Allergy 4, 489-95. 

Simon, H. U., Haj-Yehia, A., and Levi-Schaffer, F. 2000. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5 415-18. 

Mates, J. M. and Sanchez-Jimenez, F. M. 2000. Role of reactive oxygen species in apoptosis Implications for cancer therapy. Int. J. Biochem. Cell. Biol. 32 157-70. 

Petrosillo, G., Ruggiero, F.M., Di Venosa, N. and Paradies, G., Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion role of reactive oxygen species and cardiolipin, Faseb J 17 (2003) 714-716. 

Lison D and Lauweeys R (1993) Evaluation of the role of reactive oxygen species in the interactive toxicity of carbide-cobalt mixtures on macrophages in culture. Arch Toxicol 67 347-351. 

GoasduffT. and A.I. Cederbaum (1999). NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex Role of reactive oxygen species. Arch. Biochem. Biophys. 370, 258-270. 

In 1997, Stohs et al. (27A110) reviewed the potential of metal ions reacting in conjunction with other constituents of tobacco smoke to cause cellular damage by free radical reactions. Various studies had demonstrated the role of reactive oxygen species in the toxicity of transition metals. They conclnded that the presence of several reactive metal ions in tobacco smoke indicates that there may be a role for metal ions in the subsequent toxicity and carcinogenicity of tobacco smoke. They described the metal-catalyzed mechanisms that might be involved. 

Hancock, J.T., R. Desikan, and S.J. Neill Role of reactive oxygen species in cell signaling pathways Biochem. Soc. Transactions 29 (2001) 345-350. 

Hancock IT, Desikan R, Neill SJ. (2001) Role of reactive oxygen species in cell signalling pathways. Biochem Soc Trans 29 345-350. 

Role of Reactive Oxygen Species in PSII Dynamics... 

Sies H, de Groot H (1992) Role of reactive oxygen species in cell toxicity. Toxicol Lett 64-65 (Spec No) 547-551... 

FIGURE 8.4 The role of reactive oxygen species (ROS) in indncing diseases. CHD is coronary heart disease. (Adapted from Strain, J.J. and Benzie, I.F.F. 1999. Diet and antioxidant defense, in Encyclopedia of Human Nutrition, Sadler, M.J., Strain, J.J., and Caballero, B., Eds., Academic Press, San Diego, 95.)... 

Marshall, J.-A., Nichols, P.D., Hamilton, B., Lewis, R.J., and Hallegraeff, G.M. Ichthyotoxicity of Chattonella marina (raphidophyceae) to damselfish (Acanthochromis polycanthus) the synergistic role of reactive oxygen species and free fatty acids. Harmful Algae, 2, 273-281, 2003. 

Volk T, Hensel M, Schuster H, Kox WJ Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells. Mol Cell Biochem 2000 206 105-112. Irani K Oxidant signaling in vascular cell growth, death, and survival A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. CircRes 2000 87 179-183. 

Bagchi, M. et al.. Role of reactive oxygen species in the development of cytotoxicity with various forms of chewing tobacco and pan masala. Toxicology, 179,247,2002. 

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