The Role of Reactive Oxygen and Nitrogen Species

Craven and coworkers demonstrated increased free-radical production, as measured by chemiluminescence, in colonic crypts from rats treated with 

Most recently, Dvorak and colleagues demonstrated that treatment of oesophageal cells with bile-acid cocktail at low pH (4.0) stimulates superoxide anion release from mitochondria. This was associated with increased formation of the oxidative DNA lesion, 8-hydroxydeoxyguanosine in oesophageal cell lines and Barrett s biopsies effects that were not observed with bile acids at higher pH. 

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Plotnikov, E. Chupyrkina, A. Vasileva, A. Kazachenko, A. Zorov D. The role of reactive oxygen and nitrogen species in the pathogenesis of acute renal failure. 2008, BBA 1777, S58-S59. 

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