Signaling reactive oxygen species

Redox Regulation and Signaling Reactive Oxygen Species (ROS) Chemistry of Oxidative DNA Damage... 

Redox Regulation and Signalling Reactive Oxygen Species (R O S)... 

LIN J K s, LEE F, HUANG Y T, LiN-SHiAU s Y (1995) Signal transduction and oncogene expression mediated by reactive oxygen species. In Proceedings of the International Symposium on Natural Antioxidants - Molecular Mechanisms and Health Effects. Eds Packer, L, Traber, M G, Xin, W Champaign, I L, USA AOCS Press, 303-19. 

Palmer, H.J. and Paulson, K.E. 1997. Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutr Rev 55 353-361. 

Thannickal, V. J. and Fanburg, B.L. 2000. Reactive oxygen species in cell signaling Am J Physiol Lung Cell Mol Physiol 279 L1005-L1028. 

This situation may be about to change as we look at the role of iron and its implications in the formation of reactive oxygen species, with their potential to attack, modify, and ultimately destroy cells. The signalling function of ROS, not to mention RNS, has been underlined earlier. Yet, we tread a delicate, and poorly understood balance between low levels of ROS, required both for cell signalling and to maintain the antioxidative defences of the cell in a state of alert1"1, and levels which become toxic. This remains an extremely important area of therapeutic concern, since oxidative stress, whether proven to be due to iron or not, is... 

Apel K, Hirt H (2004) Reactive oxygen species metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol 55 373-399... 

Torres MA, Dangl JL (2005) Functions of the respiratory burst oxidase in biotic interactions, abiotic stress and development. Curr Opin Plant Biol 8 397 403 Torres MA, Jones JD, Dangl JL (2006) Reactive oxygen species signaling in response to pathogens. Plant Physiol 141 373-378... 

In the literature, most dmg-induced apoptosis is well known to require intracellular hyper-production of reactive oxygen species and several antioxidants inhibit apoptotic cell death. While it is clear that peroxidation reactions induce apoptosis, the precise molecular mechanism of how reactive oxygen species convey death-signals is unknown. 

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