Permissive role

Persaud SI, Harris TE, Bums CJ and Jones PM. 1999. Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets. J Mol Endocrinol 22(l) 19-28. 

R. Stoffel, S. Ziegler, N. Ghilardi, B. Ledermann, F. J. de Suvage, and R. C. Skoda, Permissive role of thrombopoeitin and granulocyte colony-stimulating factor receptors in hematopoietic cell... 

Macrophages and T cells are believed to participate in the process of )8-cell destruction. Treatment of NOD mice or BB rats with silica particles completely prevents insulitis and diabetes in these animal models (Oschilewski et al., 1985 Charlton et al., 1988). Silica particles are selectively toxic to macrophages (Levy and Wheelock, 1975 Brosnan etal., 1981), suggesting that macrophages have a permissive role in the development of insulitis and diabetes in both animal models. Evidence for the involvement of T cells has come from the observations that diabetes can be transferred to nondiabetic BB rats or NOD mice by splenic... 

Thyroid hormones affect a wide variety of peripheral tissues throughout the individual s life.8,55 In some situations, these hormones exert a direct effect on cellular function (e.g., T4 and T3 appear to increase cellular metabolism by directly increasing oxidative enzyme activity). In other instances, thyroid hormones appear to play a permissive role in facilitating the function of other hormones. For instance, thyroid hormones must be present for growth hormone to function properly. The principal effects of the thyroid hormones are listed below. 

Risso F, Grilli M, Parodi M et al (2004) Nicotine exerts a permissive role on NMDA receptor function in hippocampal noradrenergic terminals. Neuropharmacology 47 65-71 Rodrigues RJ, Alfaro TM, Rebola N et al (2005) Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J Neurochem 92 433 41... 

Noiri, E., Hu, Y., Bahou, W. F., Keese, C. R., Giaever, I., and Goligorsky, M. S. 1997. Permissive role of nitric oxide in endothelin-induced migration of endothelial cells.. /. Biol. Chem. 272 1747-1752. 

Rapid phosphorylation of the other detected phosphoproteins does occur but no definite roles have yet been ascribed to them. The 33 kDa protein may be the S6 ribosomal protein involved in the control of protein synthesis. The 57 kDa protein has been identified as the regulatory suhunit of the cyclic AMP-dependent protein kinase [44]. Of the other proteins the 76, 43 and 20 kDa may be connected with the microfilaments (43 kDa actin, 76 kDa myosin light chain kinase and 20 kDa myosin light chain) but this must be further investigated. These proteins may only play a permissive role in. steroidogenesis. The fact that the pattern of protein phosphorylation is very similar after stimulation of protein kinase C with phorbol esters supports this because the latter only marginally increase steroidogenesis [18]. 

The role of DA receptors in functions subserved by the limbic system, first of all reward and affective behavior, has been highlighted by behavioral studies which have pointed out a permissive role of the Di receptor in these functions (Sutton and Beninger, 1999). 

PKC activity is necessary to allow PKA-mediated modulation of TTX-R currents by PGE2. This scenario is reminiscent of the permissive role of PKC mediated phosphorylation on PKA induced changes in brain neuron TTX-S currents except that the phopshorylation potentiates TTX-R currents but decreases TTX-S currents. 

Sutton LC, Fleshner M, Mazzeo R, Maiser SF, Watkins LR. A permissive role of corticosterone in an opioid form of stress-induced analgesia—blockade of opiate analgesia is not due to stress-induced hormone-release. Brain Res 1994 663 19-29. 

Casillas AM, Hiura T, Li N, Nel AE. Enhancement of allergic inflammation by diesel exhaust particles permissive role of reactive oxygen species. Ann Asthma Allergy Immunol 83(6) 624—629, 1999. 

R22. Ron, D., Brasier, A. R., Wright, K. A., and Habener, J. F. The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Mol. Cell. Biol. 10, 4389-4395 (1990). 

Protein Synthesis. Two observations illustrate the role of insulin in protein synthesis The restoration of normal levels of protein synthesis in diabetics following insulin administration, and insulin s permissive role in stimulating anabolic processes, triggered by sex hormones, gonadotropins and corticosteroids. 

Although there is evidence that hormones play a role in the control of the cell cycle, this control may be indirect, i.e., the hormones may play a permissive role in division or they may influence the cell cycle through effects on expansion or metabolism. It is curious, however, that cells arrested experimentally normally arrest in either or G2 and that gibberellin and cytokinin are important for progression from G to S and G2 to M, respectively. Thus the apparent principal control periods of the cell cycle are those most noticeably responsive to hormones a relationship probably more than coincidental. 

Auxin appears to play more of a permissive role than a site-specific control function in cell division. Cell division requires auxin but transient auxin deprivation shows little or no synchronizing effect on cell proliferation in most cases. Auxin may be necessary for DNA synthesis, but it is clear that auxin acts at one or more points in the cell cycle independently of its effects on DNA synthesis. 

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