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Robinson, Mark

Blount and Robinson have extended this mode of synthesis to the preparation of iV-methyl/iomogranatonine (XXII) by the use of adipaldehyde, CHO. [CH2]4. CHO. The base, on reduetion with sodium in butyl aleohol, yields A -methyl/mmogranatoline (XXII CO — CHOH), the benzoyl derivative of which possesses marked local anaesthetic aetion. Similarly Blount, by eondensing /3-(o-formylphenyl)propaldehyde, CHO. CgH4. CHj. CHj. CHO, with methylamine and calcium acetonedicarboxylate, has prepared 8 9-benz-d - -feomogranatene-3-one (XXIII), which was reduced to the -alcohol (cf. reduction of tropinone to -tropine) and the latter converted to the benzoyl-derivative (m.p. 98°),... [Pg.61]

Robinson, Robert G., Ricardo E. Jorge, David J. Moser, Laura Acion, Ana Solodkin, Steven L. Small, Pasquale Fonzetti, Mark Hegel and Stephan Arndt, Escitalopram and Problem-Solving Therapy for Prevention of Poststroke Depression A Randomized Controlled T rial , Journal of the American Medical Association 299, no. 20 (2008) 2391-400 Rogers, Carl, On Becoming a Person A Therapist s View of Psychotherapy, London Constable, 1961... [Pg.213]

Hatchell PC, Collins AC. The influence of genotype and sex on behavioural sensitivity to nicotine in mice. Psychopharmacology 1980 71(1) 45—49. Robinson SF, Marks MJ, Collins AC. Inbred mouse strains vary in oral self-selection of nicotine. Psychopharmacology 1996 124(4) 332—339. [Pg.459]

While this example of the Robinson annulation is clearly not enantioselec-tive, the same antibody converts the mero-ketone [120] into the Wieland-Miescher (WM) decalenedione product kcM = 0.086 min-1 and Km = 2.34 mM at 25°C, parameters that give an impressive ER of 3.6 x 106. Good evidence suggests that the mechanism of the reaction involves the formation of a ketimine with the e-amino group of a buried lysine residue in the antibody, as shown in Fig. 39. Most significantly, the reaction delivers the ( )-(+)-WM product in 96% ee (by polarimetry) and in 95% ee by nmr and hplc analysis for a 100 mg scale reaction. A recent report tells that this antibody is to be made commercially available at a cost of 100 for 10 mg. The realization of that objective would mark the start of a new era of application of abzymes to organic stereoselective synthesis. [Pg.303]

Saito A, Yamashita T, Mariko Y, Nosaka Y, Tsuchiya K, Ando T, Suzuki T, Tsurao T, Nakanishi O (1999) A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci USA 96(8) 4592-4597 Schneider R, Bannister AJ, Myers FA, Thorne AW, Crane-Robinson C, Kouzarides T (2004) Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nature 6 73-77 Schwartz BE, Ahmad K (2005) Transcriptional activation triggers deposition and removal of the histone variant H3.3. Genes Dev 19 804-814... [Pg.427]

Pauly JR, Stitzel JA, Marks MJ, Collins AC (1989) An autoradiographic analysis of cholinergic receptors in mouse brain. Brain Res BuU 22 453 59 Pauly JR, Marks MJ, Robinson SF, van de Kamp JL, Collins AC (1996) Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels. J Pharmacol Exp Ther 278 361-369 Perkins K, Sayette M, Conklin C, Caggiula A (2003) Placebo effects of tobacco smoking and other nicotine intake. Nicotine Tob Res 5 695-709... [Pg.168]

Robinson SF, Pauly JR, Marks MJ, Collins AC (1994) An analysis of response to nicotine infusion using an automated radiotelemetry system. Psychopharmacology 115 115-120 Role LW, Berg DK (1996) Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16 1077-1085... [Pg.204]

Rogers DC, Jones DNC, Nelson PR, Jones CM, Quilter CA, Robinson TL, Hagan JJ (1999) Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains. Behav Brain Res 105 207-217 Rosen JB, Schulkin J (1998) From normal fear to pathological anxiety. Psychol Rev 105 325-350... [Pg.68]

Chiao, C. S. L., and Robinson, J. R. Sustained and Controlled-Release Drug Delivery Systems, 19th ed. Philadelphia Mark Publishing Company, 1995. [Pg.227]

Other figures from the classical period include H. E. Armstrong, chiefly remembered for his heuristic approach to chemical education, his dyspeptic criticism of other chemists, notably those of the Ingold/Robinson schools, and for his own research on naphthalene derivatives. He is commemorated in a recent short article 45 A chemist who has attracted more interest for his other activities than for his science is the musician Aleksandr Borodin. Several articles in 1987 marked the centenary of his death,46 8 and a longer one examined his chemistry in greater detail, notably his work on aldehydes, and the opposition encountered from Kekule49 An English... [Pg.60]

Bernard Mark Heron was born in Workington, England in 1965. After graduation (GRSC) from Lancashire Polytechnic (Preston) in 1987 and a brief period in industry he obtained his PhD (CNAA) in Benzothiopyran Chemistry in 1992 under the supervision of Professor John Hepworth at the University of Central Lancashire. A postdoctoral fellowship in heterocyclic chemistry (1992-95) and an industrially funded lectureship at Central Lancashire (1995-98) were followed by appointment to a James Robinson Lectureship at the University of Hull (1998-2000). Dr. Heron was appointed as a senior lecturer (2000-present) in the Department of Colour and Polymer Chemistry at the University of Leeds. His research interests include the chemistry and applications of heterocyclic compounds, color chemistry, and organic photo- and thermochromic materials. [Pg.954]

John D. Hepworth, James Robinson Ltd., Huddersfield, UK and B. Mark Heron,... [Pg.473]

It is unquestionable that current antipsychotic therapy is comparatively effective and at the same time disappointingly insufficient. These drugs can treat the symptoms of the disorder but certainly do not provide a cure. The great majority of patients will have between 20 and 50% reduction in symptom severity. Some will have marked improvement beyond these figures, although this is rare, and a small minority of patients will be entirely refractory to all forms of treatment currently available. Full results from antipsychotic therapy take considerable time (although initial effects on some positive symptoms can be seen in a few days). Whereas the effect of benzodiazepines on anxiety and sleep can be measured in hours, and that of antidepressants in weeks, the full impact of antipsychotic therapy is measured in months. A study by Robinson et al. (1999) showed that only 20% of patients responded after 4 weeks of treatment with conventional antipsychotics, whereas after 26 weeks the number of responders had grown to about 70%. Similar results were reported with clozapine treatment, where a response was observed in 40% of subjects after 4 weeks and in 60% of subjects by week 17 (Kane et al., 2001). Clinical observations clearly show that improvement in... [Pg.125]

In a medium of 8-10 M lithium acetate at pH 4, however, the extent of cleavage of the model peptides with both V-bromosuccinimide and V-bro-moacetamide increased markedly (Table VI). This increase in yield is probably due to the greatly decreased activity of water in concentrated salt solutions (cf. Robinson and Stokes, 1955). Under such conditions opening of the bromonium intermediate by water competes poorly with intramolecular participation of the imidole group. [Pg.251]


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See also in sourсe #XX -- [ Pg.91 , Pg.92 ]




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