Indomethacin suppositories

Indomethacin suppositories History of proctitis or recent rectal bleeding. 

Hosny, E.A. Al-Angary, A.A. Bioavailability of sustained release indomethacin suppositories containing polycarbo-phil. Int. J. Pharm. 1995, 113, 209-213. 

An IVIVC correlation was tried on indomethacin suppositories containing either suppocire (lipophilic) or poly ethylene glycol(PEG hydrophilic) as the main excipient. For both formulations, in vitro dissolution was performed with USP IV apparatus and a correlation was attempted, the results of the intrinsic validation are presented in Fig. 12 and show good predictability of the plasma concentrations in both cases. 

De Moor M, Ooghe R. A double-blind comparison of flurbiprofen and indomethacin suppositories in the treatment of... 

Hooker GD, Gregor JC, Ponich TP, McLarty TD. Diaphragm-hke strictures of the right colon induced by indomethacin suppositories evidence of a systemic effect. Gastrointest Endosc 1996 44(2) 199-202. 

Gelatin Capsules (160 mg) Indomethacin Suppositories (50 mg) Indomethacin Tablets (50 mg), DC Indomethacin Tablets (50 mg), WG Indomethacin Tablets (100 mg)... 

Profuse rectal bleeding with mucosal inflammation and necrosis has been observed following the use of indomethacin suppositories (69 ). 

Levy, N. and Gaspar, E. (1975) Rectal bleeding and indomethacin suppositories. Lancet, 1, 577. 

---