Depression, mental

Toxic effects of propranolol are related to its blocking P-adrenoceptor blocking actions. They include cardiac failure, hypotension, hypoglycemia, and bronchospasm. Propranolol is lipophilic and crosses the blood—brain barrier. Complaints of fatigue, lethargy, mental depression, nightmares, hallucinations, and insomnia have been reported. GI side effects include nausea, vomiting, diarrhea, and constipation (1,2). 

Air-poUutant effects on neural and sensory functions in humans vary widely. Odorous pollutants cause only minor annoyance yet, if persistent, they can lead to irritation, emotional upset, anorexia, and mental depression. Carbon monoxide can cause death secondary to the depression of the respiratory centers of the central nervous system. Short of death, repeated and prolonged exposure to carbon monoxide can alter sensory protection, temporal perception, and higher mental functions. Lipid-soluble aerosols can enter the body and be absorbed in the lipids of the central nervous system. Once there, their effects may persist long after the initial contact has been removed. Examples of agents of long-term chronic effects are organic phosphate pesticides and aerosols carrying the metals lead, mercury, and cadmium. 

Central nervous system-headache, apathy, drowsiness, visual disturbances (blurred vision, disturbance in yellow/green vision, halo effect around dark objects), mental depression, confusion, disorientation, delirium... 

Contact die primary care provider if nausea, vomiting, diarrhea, unusual fatigue, weakness, vision change (such as blurred vision, changes in colors of objects, or halos around dark objects), or mental depression occurs. 

Central nervous system—mental depression, mood swings, insomnia, psychosis, euphoria, nervousness, and headaches ... 

Central nervous system—headache, migraine, dizziness, mental depression... 

Nausea, skin rash, pruritus, stomatitis, vomiting, anemia, leukopenia, neutropenia, arthralgia, alopeda, asthenia, fever, infections Diarrhea, nausea, vomiting, flushing, myalgia, arthralgia, fever, peripheral neuropathy, opportunistic infections Leukopenia, nausea, vomiting, paresthesias, malaise, weakness, mental depression, headache, hypertension, alopecia, diarrhea, constipation... 

Anorexia, nausea, vomiting, mental depression, confusion, delayed or impaired thought processes, drowsiness, abdominal distention, decreased bowel sounds, paralytic ileus, muscle weakness or fatigue, flaccid paralysis, absent or diminished deep tendon reflexes, weak irregular pulse, paresthesias, leg cramps, ECG changes Hyperkalemia... 

Dependence and withdrawal can occur with all of the stimulants. Cocaine is one of the most strongly reinforcing drugs in self-administration paradigms in animals and also has a psychological withdrawal syndrome. A typical pattern of withdrawal includes a ravenous appetite, exhaustion, and mental depression, which may last for several days after the drug is withdrawn. Because tolerance develops quickly, abusers may take large doses, compared with those used medically, for example, as anorexiants. 

Other Agents Reserpine No recommendations at this time Mental depression May be used in resistant hypertension when combined with a thiazide... 

It took me a few minutes to scan the contents. In two statements, Baron von Schnitzler had cast doubt on practically everything he had said in 1945. I told them the news. The Baron now said that he "had not been technically qualified" to say many of the things he d said. As for the other admissions, he "had been in a state of intense mental depression in 1945."... 

Sprecher shouted above the din. Might as well face it — without Von Schnitzler, half the case would collapse. Belle Mayer thrust a finger near his face. "Let s be reasonable Most of his admissions were not technical at all — so where does he get off with that argument And of course he was suffering intense mental depression. Did you ever know anybody to admit anything very damaging without being depressed about it "... 

Signs and Symptoms Produces flu-like symptoms including headache, fever, eye pain, a vague feeling of bodily discomfort (malaise), nausea, vomiting, diarrhea, sore throat as well as pain in the limbs and back. Blisters and/or lesions resembling herpes virus may appear in the mouth, throat, and occasionally on the hands. Illness may produce a prolonged mental depression. 

The most serious side effect is dose-related mental depression resulting from CNS depletion of catecholamines and serotonin. This can be minimized by not exceeding 0.25 mg daily. 

A number of effects have been associated with chronic exposure to jet fuel in factory workers (Knave et al. 1978). These effects included increases in the occurrence of neurasthenia (anxiety and/or mental depression, fatigue, depressed mood, lack of initiative, dizziness, palpitations, thoracic oppression, sleep disturbances) and eye irritation. Psychological tests found that attention and sensorimotor speed were impaired in exposed workers, but there were no effects on memory functions or manual dexterity. EEG tests suggested that there may have been instability in the thalamocortical system in the exposed group. However, the type of jet fuels were not noted nor was there a control for exposure to other compounds. Inhalation exposure is likely since jet fuel vapor was detected by the study authors however, dermal and oral (i.e., eating with contaminated hands) exposures may also be possible. 

In extreme cases of intoxication, a Parkinsonism-like syndrome may result, characterized by speech disturbances, muscle spasticity, tremor, memory loss, mental depression, and marked psychic symptoms permanent disability is likely. Psychosis and suicide are established risks of overexposure to carbon disulfide. ... 

Activity in these tricyclic compounds is restricted to compounds having a two- or three-carbon side chain and methyl-substituted or unsubstituted amino groups in the side chain. Some compounds with substituents on the aromatic ring are active. Finally, the two-carbon bridge linking the aromatic rings may be -CH2—CH2— or -CH=CH—. Amitriptyline is recommended for the treatment of mental depression, with improvement in mood seen in two to three weeks after the start of medication. Imipramine is used in similar cases. 

Adverse reactions may include erythema, skin rash, nausea, abdominal distention, altered sleep patterns, irritability, mental depression, confusion, and impaired judgement. 

Depression OCs appear to be associated with an increased incidence of mental depression. 

Significant adverse reactions include fatigue headache drowsiness paresthesias difficulty in micturition diarrhea reversible increases in serum transaminases dyspnea bronchospasm asthenia muscle cramps nausea vomiting fever with aching and sore throat toxic myopathy rashes systemic lupus erythematosus vision abnormality hypoesthesia ventricular arrhythmias intensification of AV block mental depression scalp tingling. 

Habit forming Tolerance or psychological and physical dependence may occur with continued use. Administer with caution, if at all, to patients who are mentally depressed, have suicidal tendencies or a history of drug abuse. Limit prescribing and dispensing to the amount required for the interval until the next appointment. 

C. Pyrazinamide is known to cause hyperuricemia and precipitate gouty arthritis. Pyrazinamide-induced gouty arthritis does not respond to uricosuric therapy with probenecid but may respond to acetylsalicylic acid. Cycloserine (A) can cause headaches, confusion, tremors, and seizures, possibly secondary to low levels of magnesium in the cerebrospinal fluid cycloserine should be avoided in patients with epilepsy and mental depression. It is not associated with hyperuricemia. Thiacetazone (B) is an antibiotic that is rarely used in tuberculosis. The most common adverse reactions are general rashes and GI intolerance. Its use is not associated with hy-... 

Pyridoxine vitamin Bf) deficiency symptoms are generally expressed as alterations in the skin, blood, and central nervous system. Symptoms include sensory neuritis, mental depression, and convulsions. Hypochromic, sideroblastic anemia also may result. Since pyridoxine is required for the conversion of tryptophan to diphos-phopyridine and triphosphopyridine nucleotides, pellagralike symptoms can occur with vitamin Bg deficiency. This deficiency is found most often in conjunction with other B complex deficiencies. 

Drowsiness, excitation, confusion, excitement, mental depression, light-headedness, dizziness, stomach upset, nausea, sleep disturbances Rare... 

Alopecia, mental depression, dermatologic changes, headache, fever, nausea Serious Reactions... 

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