Receptors analogous

Watowich, S.I., et al. Crystal structures of influenza virus haemagglutinin in complex with high affinity receptor analogs. Structure 2 719-731, 1994. 

Methippara, M. M., Kumar, S., Alam, Md. N., Szymusiak, R., 8r McGinty, D. (2005). Effects on sleep of microdialysis of adenosine A1 and A2A receptor analogs into the lateral preoptic area of rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, 1715-23. 

Effects on sleep of microdialysis of adenosine Al and A2a receptor analogs into... 

Donohue-Rolfe, Arthur, David W.K. Acheson, Anne V. Kane, and Gerald T. Keusch. "Purification of Shiga Toxin and Shiga-Like Toxins I and II by Receptor Analog Affinity Chromatography with Immobilized PI Glycoprotein and Production of Cross-Reactive Monoclonal Antibodies." Infection and Immunity 57 (December 1989) 3888-893. 

Electrical stimulation in the vicinity of the raphe nuclei has been reported to produce depressant effects on MSRs (32,142). These depressant effects could be attributed to activation of postsynaptic inhibitory receptors analogous to those characterized in the forebrain, except for the fact that the depression was blocked by 5-HT antagonists. The effectiveness of the antagonists suggests that the receptor is more akin to the excitatory 5-HT receptor characterized on motoneurons (134,184). The depressant behavioral effects could result from... 

FIGURE 2.2 Schematic illustration of adherence (A) and anti-adhesive agents probiotics (B), adhesin analogs (C), and receptor analogs (D). 

Many bacterial adhesins and host receptors have been identified and studied in great depth, as described in Section VII. Therefore, with every new adhesin or receptor discovered, a new opportunity arises to develop an anti-adherence mechanism that may inhibit or block the adhesin-receptor interaction, which is the ultimate aim of anfi-adhesion therapy (Kahane and Ofek, 1996 Moricouf et ah, 1990 Ofek and Doyle, 1994). In actual practice, there are several t) es of anfi-adhesive mechanisms including adhesin-based vaccines, innafe hosf-derived anti-adhesives, probiotics, adhesin analogs, and receptor analogs. 

TABLE 2.3 Synthetic and naturally occurring anti-adhesive receptor analogs... 

Further confirmation of the absence of a receptor analogous to that of mammalian and avian species was obtained from binding studies carried out jLn vitro. Detergent solubilized preparations of freshly prepared homogenates, or acetone dried powders, of fish liver and kidney were assayed for specific binding activity as described previously (2, 3). In no case was it possible to... 

As mentioned above, conventional antihistamines failed to have any effect on gastric acid release. However, they also failed to inhibit other actions of histamine. For example, they failed to fully inhibit the dilation of blood vessels induced by histamine. The SK F scientists therefore proposed that there might be two different types of histamine receptor, analogous to the two types of acetylcholine receptor mentioned in Chapter 11. Histamine—the natural messenger—would switch both on equally effectively and would not distinguish between them. However, suitably... 

Homozygous VLDL receptor knockout mice are resistant to both genetic and diet-induced obesity caused by a decreased peripheral and whole-body uptake of NEFA with no alterations in eifher food intake or fat absorption [112]. The reduction in adipocyte TAG storage as shown by a decreased average fat cell size in VLDL receptor-deficient rodents implies an impaired FA delivery to adipose tissue in the absence of this lipoprotein receptor. Analogously, hepatic overexpression of hu-... 

IgD represents less than 1% of serum immunoglobulin but is widely found on the cell surfaces of B lymphocytes where it probably acts as an antigen receptor analogously to IgM. 

Hydropathy plot. The hydropathic index is plotted on they axis, with hydrophobic domains at the top and hydrophilic domains at the bottom. The x axis shows the amino-acid residue number from the amino to the carboxy terminus. The protein shown is a 7-transmembrane receptor (the serotonin receptor), analogous to the epinephrine (adrenalin) receptor. The approximate positions of the seven transmembrane segments are indicated by the purple bars. (Original plot graciously provided by... 

Analogs of des Arg -bradykinin or des Arg °-kallidin are selective antagonists for kinin-Bj receptors. Analogs of [Dphen ] bradykinin are antagonists for kinin-B2 receptors. Activation of the B2-kinin receptors, in virtually all the tissues so far described, leads to stimulation of phosphati-dylinositol (Pl)-specific phospholipase C, resulting in the formation of inositol phosphates and diacylglycerol, and snbseqnent elevations in the intracellular calcium concentration. In addition, bradykinin-indnced increases in the intracellnlar calcinm concentrations of human airway smooth mnscle appear to be mediated both by activation of PLC-PI tnmover and by calcinm inflnx via receptor-operated calcinm channels. 

Receptor 14 [42] (Structure 8) was prepared so as to bind a bifunctional guest such as sodium p-nitrophenoxide. In the complex, face-to-face %-n, lipophilic, and ion-dipole interactions are considered to work simultaneously. A more rigid three-dimensional receptor analog 15 [43] (Structure 8) was also made. It shows complexing abilities for both potassium p-nitrophenoxide and CH2CI2. 

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