High-affinity IgE receptors

D, Kinet JP, Stingl G The high affinity IgE receptor (FceRI) mediates IgE-dependent allergen presentation. J Immunol 1995 154 6285-6290. 

Our understanding of anaphylaxis has advanced substantially since the original description of this phenomenon in the scientific literature over 100 years ago. There is now little reasonable doubt that the IgE-dependent activation of mast cells and basophils is the key event underlying most examples of allergen-induced anaphylaxis in humans [3-5]. IgE binds to the high-affinity IgE receptor, FcsRI, expressed on the... 

Spiegel DE. Tucker J. Battaile JT. Alevy Y, Yan L. Agapov E. Kim EY. Holtzman MJ Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 2007 204 2759-2769. 37... 

Hide M, Francis DM, Grattan CEH, Hakimi J, Kochan JP, Greaves MW Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 1993 328 1599. Sd... 

Basophil selection cells with high-affinity IgE receptors... 

Louahed, J., Kermouni, A., van Snick, J. and Renauld, J.C. (1995) IL-9 induces expression of granzymes and high affinity IgE receptor in murine T helper cell clones. Journal of Immunology 154, 5061-5070. 

Torn, H., Pawankar, R., Ra, C., Yata, J. and Nakahata, T. (1998) Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking enhanced ILrl3 production by IU4-primed human mast cells. Journal of Allergy and Clinical... 

SHIP SH2 domain binds to the phosphorylated mM (p-ITIM) of other inhibitory co-receptors (gp49Bl) (Kuroiwa etal, 1998) and to the p-ITIM-like motif of the adhesion receptor, PECAM-1 (Pumphrey et al., 1999), furthermore, in vitro it binds to the phosphorylated immimoreceptor tyrosine based activation motifs (p-TTAM) within the p and y subunits of the high affinity IgE receptor (Kimura et al. 1997)), and the zeta chain of T cell receptor (Osborne et al, 1996). However, in vivo coprecipitation of these molecules was not observed. 

Kimura T., Sakamoto, H., Appella, E., and Siraganian, R.P. 1997. The negative signaling molecule SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP) binds to the tyrosine phosphorylated P subunit of the high affinity IgE receptor. J. Bio.Chem. 272 ... 

Osborn, M.A., Zenner,G., Lubinus M., Zhang X., Songyang, Z., Cantley, L.C., Majerus, P., Bums, P., and Kochan, J.P., 1996, The inositol 5-phosphatase SHIP binds to the mmunoreceptor signahng motifs and responds to high affinity IgE receptor aggregation. J. Biol. Chem. 271 29271-29278. 

Sandford AJ, Shirakawa T, Moffatt MF, Daniels SE, Ra C, Faux JA, Young RP, Nakamura Y, Lathrop GM, Cookson WO. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc Epsilon RI) on chromosome llq. Lancet 1993 341(8841) 332-334. 

Nakamura, G. R., Reynolds, M.E., Chen,Y.M., Starovasnik,M.A. andLowman, H.B. (2002) Stable zeta peptides that act as potent antagonists of the high-affinity IgE receptor. Proc. Natl. Acad. Sci. USA 99,1303-1308. 

Scarselli E, Esposito G, Traboni C, Receptor phage. Display of functional domains of the human high affinity IgE receptor on the Ml3 phage surface, FEBS Lett., 329 223-226, 1993. 

Wofsy C, Vonakis BM, Metzger H, Goldstein B. One Lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors. Proc. Natl. Acad. Sci. U.S.A. 1999 96 8615-8620. 

Gounni, A.S., Lamkhioued, B., Tanaka, Y., Delaporte, E., Capron, A., Kinet, J.P. and Capron, M. (1994). High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 367, 183-186. 

Li A, Hopkin J Atopy phenotype in subjects with variants of the beta subunit of the high affinity IgE receptor. Thorax 1997 52 654-655. (Ill)... 

Omalizumab is a monoclonal antibody that selectively binds to human IgE, inhibiting the binding of IgE to the high-affinity IgE receptor on the surface of mast cells and basophils, and limiting the degree of release of mediators of the allergic response. It is indicated in the treatment of moderate to severe persistent asthma in patients who have a positive skin test or in vitro reactivity to a perennial aero-allergen and whose symptoms are inadequately controlled with inhaled corticosteroids. 

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