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Anti-adhesive agents

Dendritic and Hyperbranched Glycoconjugates as Biomedical Anti-Adhesion Agents... [Pg.361]

This chapter will provide an overview of the research on anti-adhesion agents. Particular attention will be devoted to the anti-adherence agents derived from or foimd naturally in foods. In addition, the pathogen infection process, the architecture of host epithelial cell surfaces, and the chemistry and mechanisms involved in bacterial interactions with host cell surfaces will also be reviewed. [Pg.103]

There are some pofenfial limifafions of anti-adhesive strategies that must also be recognized. Pathogenic bacteria often encode genes for more than one type of adhesin, and, via a process knovm as phase variation (Flenderson et al., 1999), express adhesins on either a random or perhaps "as-needed" basis. Therefore, a cocktail of different anti-adhesive agents... [Pg.129]

FIGURE 2.2 Schematic illustration of adherence (A) and anti-adhesive agents probiotics (B), adhesin analogs (C), and receptor analogs (D). [Pg.129]

Anti-adhesive agents have been sought to prevent the sticking of the bacteria to teeth but generally these have not been successful, and bacteriocides are normally used. The problem is the mechanism of the bacterial adhesion, as shown in Fig. 12.25. It is thought that a fdm of polymer from saliva first attaches to the hydroxyapatite. Then bacteria attach to this coating. The bacteria produce a complex layer of cell sheath which glues the cells to each other. [Pg.298]

Other compounds that may be present in a reservoir system are a dispersion medium of solvent, glidants or anti-adhesive agents (titanium oxide, talc, magnesium stearate, etc.), and agents that further influence the release (various water soluble, but also fat-soluble compounds. [Pg.72]

Some applications, such as incise drapes require loading of the PSA matrix with anti-bacterial agents. Proper selection of the monomers allows the PSA to be compatible with compounds like iodine, while maintaining the adhesion to the skin. [Pg.527]

Inhibition of leucocyte adhesion to endothelium. By acting on the gene transcription factor called nuclear factor kappa B (NFkB), NO limits the expression by endothelial cells of monocyte chemotactic protein-1 (MCP-1) and VCAM-1. As both MCP-1 and VCAM-1 are involved with pro-inflammatory responses, NO is in this manner an anti-inflammatory agent ... [Pg.135]

Silva et al. (2006) studied starch-based microparticles as a novel strategy for tissue engineering applications. They developed starch-based microparticles, and evaluated them for bioactivity, cytotoxicity, ability to serve as substrates for cell adhesion, as well as their potential to be used as delivery systems either for anti-inflammatory agents or growth factors. Two starch-based materials were used for the development of starch-based particulate systems (1) a blend of starch and polylactic acid (SPLA) (50 50 w/w) and (2) a chemically modifled potato starch, Paselli II (Pa). Both materials enabled the synthesis of particulate systems, both polymer and composite (with BG 45S5). A simple solvent extraction method was employed for the synthesis of SPLA and SPLA/BG microparticles, while for Pa and Pa/BG... [Pg.450]

White blood cells readily traverse the blood-brain barrier 12-24 hours after ischaemia and contribute to the excessive production of oxygen free radicals. Eventually the infarcted zone becomes infiltrated with lymphocytes, polymorphs and macrophages. The cytokines released from the macrophages contribute to the injury of the vessel walls and to the consequent oedema, haemorrhage and necrosis. Thus the function of the anti-inflammatory agents is to reduce the initial adhesion of the white blood cells and thereby limit the extent of the inflammatory response. [Pg.374]

In contrast to the functional information available for the roles of ACh and AChE, the function or functions of RBC and serum ChEs are still matters for speculation. One idea is that they protect the body from natural anti-ChE agents (e.g., phyosos-tigmine) encountered during the evolution of the species another idea is that they have specific but still unknown roles in tissues. For example, there are reports that inhibition of BuChE activity blocks adhesion of neurites from nerve cells in culture and that AChE promotes outgrowth of neurites as if the enzymes had roles in cell adhesion and differentiation. [Pg.590]


See other pages where Anti-adhesive agents is mentioned: [Pg.127]    [Pg.103]    [Pg.129]    [Pg.131]    [Pg.138]    [Pg.139]    [Pg.76]    [Pg.177]    [Pg.260]    [Pg.69]    [Pg.208]    [Pg.186]    [Pg.97]    [Pg.333]    [Pg.229]    [Pg.117]    [Pg.127]    [Pg.103]    [Pg.129]    [Pg.131]    [Pg.138]    [Pg.139]    [Pg.76]    [Pg.177]    [Pg.260]    [Pg.69]    [Pg.208]    [Pg.186]    [Pg.97]    [Pg.333]    [Pg.229]    [Pg.117]    [Pg.582]    [Pg.92]    [Pg.321]    [Pg.232]    [Pg.130]    [Pg.167]    [Pg.529]    [Pg.128]    [Pg.132]    [Pg.175]    [Pg.186]    [Pg.269]    [Pg.246]    [Pg.128]    [Pg.7]    [Pg.314]    [Pg.195]    [Pg.868]    [Pg.464]    [Pg.7]   
See also in sourсe #XX -- [ Pg.103 , Pg.128 , Pg.129 , Pg.130 , Pg.131 , Pg.132 , Pg.133 , Pg.134 , Pg.135 , Pg.136 , Pg.137 , Pg.138 ]




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Anti-adhesive

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