Anti-adherents

Adherence, Anti-Adherence, and Oligosaccharides Preventing Pathogens from Sticking to the Host... 

This chapter will provide an overview of the research on anti-adhesion agents. Particular attention will be devoted to the anti-adherence agents derived from or foimd naturally in foods. In addition, the pathogen infection process, the architecture of host epithelial cell surfaces, and the chemistry and mechanisms involved in bacterial interactions with host cell surfaces will also be reviewed. 

Many bacterial adhesins and host receptors have been identified and studied in great depth, as described in Section VII. Therefore, with every new adhesin or receptor discovered, a new opportunity arises to develop an anti-adherence mechanism that may inhibit or block the adhesin-receptor interaction, which is the ultimate aim of anfi-adhesion therapy (Kahane and Ofek, 1996 Moricouf et ah, 1990 Ofek and Doyle, 1994). In actual practice, there are several t) es of anfi-adhesive mechanisms including adhesin-based vaccines, innafe hosf-derived anti-adhesives, probiotics, adhesin analogs, and receptor analogs. 

Kahane, L, and Ofek, I. (1996). "Toward Anti-Adherence Therapy for Microbial Disease." Plenum Press, New York, NY. 

Sharon, N. (2006). Carbohydrates as future anti-adherence drugs for infectious diseases. Biochim. Biophys. Acta 1760,527-537. 

This technique is used for packaging and industrial multilayer films, often of hybrid nature associating a thermoplastic with paper, cardboard, aluminium foil... Some applications are, for example, barrier films, anti-adherent films, credit cards, wallpapers. .. 

After the composite has been manufactured onto its mould, an anti-adherent flexible sheet is applied onto it, and then a light vacuum is created by a suitable system (see Figure 5.24). 

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