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Water purified

Purified water is water obtained by a suitable process. It is prepared from water complying with the U.S. Environmental Protection Agency National Primary Drinking Water Regulations or comparable regulations of the European Union or Japan. It contains no added substances. [Pg.203]

Since no added substances are allowed, if chloride and ozone are applied in the preparation of purified water, the following should be ensured tests for total organic carbon and conductivity apply to purified water produced on site for use in manufacturing. Purified water packaged in bulk for commercial use elsewhere shall meet requirements of all tests under sterile purified water, except labeling and sterility, per USP XXIV. [Pg.203]

In continuous production facilities (minimum 10 working days), water should be sampled at least weekly. [Pg.203]

From noncontinuous production facilities water must be sampled from each production batch. [Pg.203]

Total aerobic viable count Establish in-house requirements [Pg.204]

Purified water is typically prepared by ion exchange, reverse osmosis or a combination ofthe two treatment processes. Purified water is intended for use as an ingredient in the preparation of compedial dosage forms. It contains no added substances, and is not intended for use in parenteral products. It contains no chloride, calcium, or sulfate, and is essentially free of ammonia, carbon dioxide, heavy metals, and oxidizable substances. Total solids content will be no more than 10 ppm, pH will be 5-7, and the water will contain no coliforms. The United States Pharmacopoeia National Formulaiy (USP) requires that purified water comply with EPA regulations for bacteriological purity of drinking water (40 CFR 141.14, 141.21). Table 4 is a quantitative interpretation of United States Pharmacopoeia XXI standards for purified water.  [Pg.601]

The purified water temperature is typically maintained at 60 to 80°C (hot), ambient, or 4°C (cold). A number of heat exchangers are located around the loop and after the DI system to achieve and maintain the desired temperature. Ifthe system is hot, point-of-use heat exchangers should be used to obtain ambient water. A design engineer would need to evaluate a given system, and strategically locate and size heat exchangers to both maintain the temperature in the loop and to provide water to the use points at the desired temperatures. [Pg.602]

Regardless of the system temperature selected, the storage tank and the loop must be sanitized periodically. For the stainless steel system outlined above, sanitization implies raising the water temperature to 80°C (at a minimum) at the cold point and maintaining it for the validated time interval. This is often done automatically off shift. [Pg.602]

The water treatment plant produces Purified Water. The unit that fills the 1000-liter storage tank is located in building C first floor from where a loop will start to distribute water in building C. A separate distribution loop starts in building C and allows filling of tanks in buildings A and B. [Pg.67]


Bacterial Endotoxias Test (85)," "Biological Reactivity Tests, in vivo (88)," "Particulate Matter ia Injections (788)," and "Purified Water," JJSP 23 The U.S. Pharmacopeia Convention, RockviUe, Md., 1994. [Pg.146]

Water Treatment. Flotation in water treatment is used both for the removal of dissolved ions such as Cu ", Cr ", or (PO or surfactants and suspended soHds as in the case of sludge treatment. The final product in this case is purified water rather than a mineral concentrate. Furthermore, water is treated either for drinking purposes (potable water preparation) or safe disposal to the environment. [Pg.52]

Electrodialysis. Electro dialysis processes transfer ions of dissolved salts across membranes, leaving purified water behind. Ion movement is induced by direct current electrical fields. A negative electrode (cathode) attracts cations, and a positive electrode (anode) attracts anions. Systems are compartmentalized in stacks by alternating cation and anion transfer membranes. Alternating compartments carry concentrated brine and purified permeate. Typically, 40—60% of dissolved ions are removed or rejected. Further improvement in water quaUty is obtained by staging (operation of stacks in series). ED processes do not remove particulate contaminants or weakly ionized contaminants, such as siUca. [Pg.262]

Hquid—Hquid-phase spHt the compositions of these two feed streams He oa either side of the azeotrope. Therefore, column 1 produces pure A as a bottoms product and the azeotrope as distillate, whereas column 2 produces pure B as a bottoms product and the azeotrope as distillate. The two distillate streams are fed to the decanter along with the process feed to give an overall decanter composition partway between the azeotropic composition and the process feed composition according to the lever rule. This arrangement is weU suited to purifying water—hydrocarbon mixtures, such as a C —C q hydrocarbon, benzene, toluene, xylene, etc water—alcohol mixtures, such as butanol, pentanol, etc as weU as other immiscible systems. [Pg.193]

Fig. 5. Schematic continuous flow reactor for characterizing the effectiveness of active carbons for purifying water. Fig. 5. Schematic continuous flow reactor for characterizing the effectiveness of active carbons for purifying water.
Influent water enters one end of the pressure vessel and travels longitudinally down the length of the vessel in the feed transport layer. Direct entry into the permeate transport layer is precluded by sealing this layer at each end of the roll. As the water travels in a longitudinal direction, some of it passes in radially through the membrane into the permeate transport layer. Once in the transport layer, the purified water flows spirally into the center collection tube and exits the vessel at each end. The concentrated feed continues along the feed transport material and exits the vessel on the opposite end from which it entered. [Pg.330]

The following technologies are among the most commonly used physical methods of purifying water ... [Pg.33]

Ozone is used extensively in Europe to purify water. Ozone, a moleeule eomposed of 3 atoms of oxygen rather than two, is formed by exposing air or oxygen to a high voltage eleetrie are. Ozone is mueh more effective as a disinfectant than... [Pg.40]

Treatment of a water supply is a safety factor, not a corrective measure. There are a number of ways of purifying water. In evaluating the methods of treatment available, the following points regarding water disinfectants should be eonsidered ... [Pg.45]

The principal elements of the system include an aeration tank in which the wastewater is thoroughly mixed with continuously activated sludge and oxygen. From this part of the process, it passes into a clarifier tank, where the settled sludge is removed from the purified water to be recycled by the return activated sludge pumps. [Pg.167]

FIGURE 6.40 Calibration curves of Shodex PROTEiN KW-800 series. Column Shodex PROTEiN KW-802.S, KW-803, KW-804, 8.0 mm i.d. X 300 mm. Eiuent Pullulan, PEG PEO Purified water, Protein SO mM Sodium phosphate buffer + 0.3 M NaCI (pH 7.0). Flow rate 1.0 mL/min. Detector Pullulan. PEG PEO Shodex Rl Protein Shodex UV (220 nm). Column temp. Ambient. [Pg.214]

There are many sad examples of installations that have gone disastrously wrong, and these are by no means limited to small facilities or those in which water is a relatively unimportant service. For example, manufacture of microchips is wholly dependent on a supply of highly purified water. In recent years two of the largest UK manufacturers, sited at opposite ends of the country, have had to shut down and send the workforce home because their purified water facility had failed. [Pg.472]

Dichlorine oxide is used as bactericide to purify water ft is produced by the chlorination of sulfur dioxide gas. [Pg.127]

Kohlrausch and Heydweiller (1894) found that the most highly purified water that can be obtained possesses a small but definite conductivity. Water must... [Pg.36]

An alternative method of purifying water is by reverse osmosis. Under normal conditions, if an aqueous solution is separated by a semi-permeable membrane from pure water, osmosis will lead to water entering the solution to dilute it. If, however, sufficient pressure is applied to the solution, i.e. a pressure in excess of its osmotic pressure, then water will flow through the membrane from the solution the process of reverse osmosis is taking place. This principle has been... [Pg.90]

A process requires a flow of 4 kg/s of purified water at 340 K to be heated from 320 K by 8 kg/s of untreated water which can be available at 380, 370, 360 or 350 K. Estimate the heat transfer surfaces of one shell pass, two tube pass heat exchangers suitable for these duties. In all cases, the mean heat capacity of the water streams is 4.18 kJ/kg K and the overall coefficient of heat transfer is 1.5 kW/m2 K. [Pg.538]

On the other hand, potential measurements at the free surface of purified water have shown50 that the value for a flowing surface differs by about 0.3 V from that for a quiescent surface, as a result of adsorption of surface-active residual impurities in the solution (probably also coming from the gas phase). Since emersed electrodes drag off the surface layer of the solution as they come out of the liquid phase, the liquid layer attached to emersed solid surfaces might also be contaminated. [Pg.14]

A primary goal of this chapter is to learn how to achieve control over the pH of solutions of acids, bases, and their salts. The control of pH is crucial for the ability of organisms—including ourselves—to survive, because even minor drifts from the optimum value of the pH can cause enzymes to change their shape and cease to function. The information in this chapter is used in industry to control the pH of reaction mixtures and to purify water. In agriculture it is used to maintain the soil at an optimal pH. In the laboratory it is used to interpret the change in pH of a solution during a titration, one of the most common quantitative analytical technique. It also helps us appreciate the basis of qualitative analysis, the identification of the substances and ions present in a sample. [Pg.565]

The overall sensitivity of the sampling and concentrating system was examined using acetophenone as the solute. Purified water (water that had been passed through a reversed-phase column) was used to make... [Pg.207]

Purified Water, which may be used for cleaning/rinsing or to prepare oral-dosage drugs... [Pg.220]

Table 11.3 Specifications for United States Pharmacopoeia (USP) grade Purified Water and Water for Injection. Table 11.3 Specifications for United States Pharmacopoeia (USP) grade Purified Water and Water for Injection.
Shevchenko MA, Taran PH, Marchenko PV. 1982. Modem methods of purifying water from pesticides. Soviet J Water Chem Technol 4 53-71. [Pg.230]


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