Leucine rich repeats

Kajava, A.V., Vassart, G., Wodak, S.J. Modelling of the three-dimensional structure of proteins with the typical leucine-rich repeats. Structure 3 867-877, 1995. 

Kobe, B., Deisenhofer, J. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 366 751-756, 1993. 

Signaling by PKC is terminated by concentrations of its ligands dropping to basal levels (i.e., Ca2+ and diacylglycerol) and by dephosphorylation of the three processing sites. Dephosphorylation is controlled, in part, by a recently discovered hydrophobic phosphorylation motif phosphatase. This phosphatase, PHLPP (for PH domain Leucine-rich repeat Protein Phosphatase) dephosphorylates conventional and novel PKC isozymes, initiating their downregulation. 

The von Willebrand factor (vWf) is a heterogeneous multimeric plasma glycoprotein produced by megakaryocytes and endothelial cells which is found in platelets, plasma and the subendothelium. Subendothelial vWf facilitates platelet adhesion, especially under high shear stress, by binding to glycoprotein GPIb-V-IX, a complex of four leucine-rich repeat proteins on platelets. 

At least 12 ditferent TLRs have so far been identified in mammals (Uematsu and Akria 2007). TLRs are type I transmembrane PRRs that possess an extracellular domain contaiiung leucine-rich repeats (LRR), a transmembrane domain, and an... 

Li, Z.H., Molecular cloning and characterization of phytoene desaturase cDNA and leucine-rich repeat protein kinase cDNA from maize, PhD dissertation. Graduate School and University Center, City University of New York, 1998. 

The crystal structure of one LRR protein, the RNAse inhibitor, has revealed that leucine-rich repeats correspond to p-a structural units. This units are arranged for a parallel p-sheet with one surface exposed to solvent so that the protein acquires an unusual non-globular shape, which may be responsible for proteinbinding functions [57]. 

A third myelin inhibitory protein, OMgp, is a GPI-linked protein expressed by oligodendrocytes [18], OMgp is a relatively minor component of myelin, believed to be localized to the paranodal loops, next to the node of Ranvier. OMgp contains a leucine-rich repeat (LRR) domain and a C-terminal domain with serine/threonine repeats. Like MAG, OMgp is also found in the PNS. Like Nogo, OMgp is also expressed in adult neurons. 

LKRK2 Leucine-rich repeat kinase dardarin 12ql2 Dominant Unknown... 

LRR leucine-rich repeat NARP/MILS neuropathy, ataxia, retinitis pigmentosa/maternally... 

Crustacea Arthropods, Crustaceans, Insects Lectins, PO, Leucine rich repeats, Toll, Tol interleukin receptors, AMPs, complement... 

Echinodermata Starfish, Sea urchins Lectins, PO, leucine rich repeats, complement, scavenger receptors, Tol interleukin receptors, cytokines... 

Evdokimov, A. G., Anderson, D. E., Routzahn, K. M., and Waugh, D. S. (2001). Unusual molecular architecture of the Yersinia pestis cytotoxin YopM A leucine-rich repeat protein with the shortest repeating unit./. Mol. Biol. 312, 807-821. 

Kajava, A. V. (1998). Structural diversity of leucine-rich repeat proteins. J. Mol. Biol. 277,... 

Kajava, A. V., and Kobe, B. (2002). Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci. 11, 1082-1090. 

Kobe, B., and Deisenhofer, J. (1994). The leucine-rich repeat A versatile binding motif. 

Fig. 2. Examples of the structures of protein domains and repeats. The images were generated using Molscript (Kraulis, 1991). (A) Immunoglobulin domain (PDB identifier ltlk) (Holden et al1992), (B) A zinc finger domain with coordinated zinc ion (PDB identifienlzaa) (Pavletich and Pabo, 1991). (C) A /3-propeller domain composed of seven WD40 repeats (PDB identifier lgp2) (Wall et al., 1995), (D) An elongated domain of variant leucine-rich repeats (PDB identifienllrv) (Peters et al., 1996).

LRRCT Leucine rich repeat C-terminal domain E(M) 0(0) 7(9) ... 

II.2f Phlpp +103 kb (il) R 1E2.1 0 PH domain and leucin rich repeat protein phosphatase, dephos phorylates Akt, promotes apoptosis, and snppresses tnmonr growth 2... 

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