Protein secretion signal-recognition particle

How are the possible choices for newly formed proteins made Much seems to depend upon the amino acid sequences at the ends of the polypeptide chains. As they emerge from a ribosome, some N-terminal signal sequences bind to recognition proteins. One such protein labels the ends of proteins destined for secretion into the vesicles of the ER. This protein ensures that the protein end binds to the signal recognition particle (SRP), enters a translocon pore, and undergoes cotranslational passage into the periplasmic space in bacteria or the ER in eukaryotes. Cotranslational modification reactions also occur both in the... 

S/7 S 79-522 nt universal signal recognition particle-mediated protein secretion... 

Zanen, G. et al (2006) Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis. Proteomics,... 

The processes by which proteins are selected for secretion into the periplasmic space of bacteria or into the vesicles of the endoplasmic reticulum of eukaryotic cells are similar and have been discussed in Chapter 10 (pp. 519-521). However, some details are still being worked out. The first step in translocation is binding of the N terminus of a protein that is emerging from a ribosome to the signal recognition parti-cje 563,564 j le core 0f this particle has a universally conserved structure consisting of two proteins and an RNA molecule.565 571 b... 

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