Protein surface recognition

Klaikherd A, Sandanaraj BS, Vutukuri DR, Tha3mmanavan S. Comparison of facially amphiphilic biaryl dendrimers with classical amphiphiUc ones using protein surface recognition as the tool. J Am Chem Soc 2006 128 9231-9237. 

Srivastava S, Verma A, Frankamp BL, Rotello VM. Controlled assembly of protein-nanoparticle composites through protein surface recognition. Adv Mater 2005 17 617-621. 

Park, H. S., Lin, Q., Hamilton, A. D., Protein surface recognition by synthetic receptors A route to novel submicromolar inhibitors for alpha-chymotrypsin. J. Am. Chem. Soc. 1999, 121, 8-13. 

Home WS, Johnson LM, Ketas TJ et al (2009) Structural and biological mimicry of protein surface recognition by a/P-peptide foldamers. Proc Natl Acad Sci USA 106 14751-14756... 

Equally, stabilizing protein-protein interactions has considerable therapeutic potential. For instance, p53 is an important cell cycle protein involved in programmed cell death (apoptosis), which associates to form a tetramer in vivo Furthermore, p53 mutations are commonplace in a wide variety of cancers.Giralt et al. have investigated the development of protein surface recognition sequences that are rich in positively charged residues and bind to anionic domains in monomeric p53 and concluded that such an approach offers considerable potential for targeting the cell cycle in cancerous cells. 

This approach to protein surface recognition represents a powerful strategy for future development. These... 

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