Recognition of Proteins with Aminopyrazoles

S = solution, P = pellet. Left typical prion rods (white bar 100 nm) [25]. Right schematic representation of the concept capping the -sheets [26]. 

The biophysical experiments of our cooperation partners focus mainly on two different techniques - a rough estimate of aggregation prevention is found by differential ultracentrifugation (UC), but more detailed information about the kinetics and aggregate size comes from fluorescence correlation spectroscopy (FCS) [24]. 

1 Review R. Hirschmann, Angew. Chem. Int. Ed. Eng. 1991, 30, 1278 fi-strand peptidomimetics A. B. Smith 

3 Reviews (a) T. Wisniewski, P. Aucouturier, C. Soto, B. Fran-gione, Amyloid Int. J. Exp. Clin. 

Mehlhorn, H. Serban, S. B. Prusiner, D. Riesner, Biol. Chem. 1998, 379, 1307 K. Jansen, O. Schafer, E. Birkmann, K. Post, H. Serban, S. B. Prusiner, D. Riesner, Biol. Chem. 2001, 382, 683-691. 

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