Primary secondary amine

Carbamoyl-glucuronide Glycosylation hexose (Glc) primary secondary amines... 

These were first investigated and used in rubber as accelerators. Their effect in improving the vulcanizing and ageing properties of rubber was utilized for several years. Primary diamines, primary secondary amines and aminophenols are much more active than simple primary amines. Aminophenol and phenolamine salts are effective antidegradents. 

R = aryl, pyridyl, furanyl, thiophenyl r2 = r3 = H, primary, secondary amines... 

IF (functional group of active ingredient is primary/secondary amine )... 

Wettability Water stability Photostability Susceptible to hydrolysis Primary/secondary amines Hygroscopicity Poured density (gcm )... 

For the sample cleanup, 1 mL of the upper acetonitrile layer is mixed with 25 mg of primary secondary amine (PSA) adsorbent and 150 mg of MgS04 and shaken for 30 seconds. The organic layer is centrifuged at 6000 rpm for 60 seconds and used for GC-MS analysis. 

Solution-polymerized SBR is made by termination-free, anionic/live polymerization initiated by alkyl lithium compounds. Other lithium compounds are suitable (such as aryl, alkaryl, aralkyl, tolyl, xylyl lithium, and ot/p-naphtyl lithium as well as their blends), but alkyl lithium compounds are the most commonly used in industry. The absence of a spontaneous termination step enables the synthesis of polymers possessing a very narrow molecular weight distribution and less branching. Carbon dioxide, water, oxygen, ethanol, mercaptans, and primary/secondary amines interfere with the activity of alkyl lithium catalysts, so the polymerization must be carried out in clean, near-anhydrous conditions. Stirred bed or agitated stainless steel reactors are widely used commercially. 

USE Derivatizing agent for primary, secondary amines, la sequencing of peptides by Ed man degradation. In amino add analyses by HPLC (Pico-Tag). 

Primary secondary amine (PSA) is the most common sorbent used in pesticide residue analysis because it can effectively retain organic acids present in food. C18 or a... 

Ci8, Cg, and divinylbenzene polymers) are predominantly used for retention of pesticides from water samples followed by their selective elution by small solvent volumes. In food applications, another SPE approach called chemical filtration , i.e., adsorption of matrix components, such as sugars and fatty acids on aminopropyl (-NH2) or primary secondary amine (PSA) sorbents, while analytes remain in the extract, can be conveniently employed in cartridge or disk formats or as a novel dispersive SPE clean-up (mixing of a small amount of sorbent with the extract). 

A similar reaction was reported by Zhao and co-workers [46] in 2009. The reaction was catalyzed by primary/secondary amines affording the final cyclohexenes in good yields and stereoselectivities. 

Matrix solid-phase dispersion (MSPD) is an SPE variant where samples are ground and mixed with a support. In the initial application, samples were placed in a disposable column previously packed with Florisil, which trapped the fat from the sample and allowed the compounds of interest to be eluted. This has successfully been applied to the determination of lipophilic pesticides from both fatty and non-fatty matrixes. Recently, an orthogonal technique, dispersive solid-phase extraction, for the isolation and analysis of a variety of pesticides on numerous food matrixes has been introduced. The technique is called QuEChERS, which stands for quick, easy, cheap, effective, rugged, and safe. The technique offers advantages in time and solvent usage since it uses approximately 10 ml of solvent per sample when compared to the potentially hundreds of milliliters of solvent used for more standard extraction and isolation protocols. It uses a combination of MgS04 and primary secondary amine (PSA) sorbent not only to remove water and non-target compounds, but also isolate the compounds of interest. 

Amines, carboxylic acids, and isonitriles. A wide range of primary/ secondary amines (95,398), carboxylic acids (2,158), and isonitriles (644) are commercially available from the Available Chemical Directory (ACD) as of September 2007 (Table 1). The compounds used for the Ugi reaction on the aldehyde activated agarose vary from case to case they must be dissolved in an appropriate buffer, either an aqueous solution or an organic solvent such as methanol. Table 2 presents the list of the different amines (A1-A8), carboxylic acids (C1-C6), and isonitrile (II) components used for the Ugi combinatorial library prepared in this work (see Note 4). 

Akzo Chemie Method VE/3.001 Ethoxylated fatty amines/diamines Determination of primary + secondary amine. 

Carbonylative Amination Among cross-coupling reactions, palladium-catalyzed aminocarbonylation is an interesting regioselective procedure to prepare amides [73]. The methodology consists of three-component coupling of aryl or alkynyl haUdes, primary/secondary amines, and carbon monoxide. 

Simultaneously to Orellana s results, Bhanage and cowoikm desaibed a green catalytic procedure for the aminocarbonylation of aryl iodides with amines. The reaction was carried out using water as solvent and a polymer-supported Pd-NHC catalyst (PS-Pd-NHC, XXIV Scheme 5.55), which could be easily recycled up to four consecutive runs without loss of activity or selectivity. This protocol allowed the aminocarbonylation of different aryl iodides with both aryl and alkyl primary/secondary amines using 100 psi of carbon monoxide. In aU studied examples, the corresponding amides 77 were obtained in good to excellent yields, except for aromatic secondary amines [75]. 

The robust aUyUc Pd-NHC complex XXV (Fig. 5.3) has also been described to catalyze aminocarbonylation of various hetero(aryl) iodides with primary/secondary amines under atmospheric carbon monoxide pressure. This catalyst tolerated a broad range of functional groups, electronic properties, as well as buUdness on hetero(aryl) iodides and amines, affording in aU cases the corresponding amides 77 in good to excellent yields [76]. 

SCHEME 5.55 Aminocarbonylation of aryl iodides with primary/secondary amines using PS-Pd—NHC XXIV (PS denotes poly(imidazoliummethyl styiene)-surface grafted polystyrene resin). 

A three-component solvent-free Mannich reaction was developed by Nayak in 2011 [62], The reaction was catalyzed by camphorsulfonic acid, giving the Mannich adducts in good yields. The authors applied this method to synthesize aminochromanols. A similar reaction was developed by Larsen based on cyclohexanone [63], As shown in Scheme 11.15, the reaction of cyclohexanone 90 with primary/secondary amines 92 afforded the corresponding imines that reacted with an alkyne, n-hexylacetylene 91, catalyzed by CuCl. The reactions were carried out under solvent-free conditions at 110°C to afford the corresponding amine derivatives 93 in good to excellent yields (61-98%). 

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