Slowly Biofissionable Pt-N Complexes Anchored through Primary and Secondary Amines

Slowly Biofissionable Pt-N Complexes Anchored through Primary and Secondary Amines 

Carrier-bound drug systems designed to perform as described in Section VII. A should contain suitable cleavage sites permitting drug release. These release mechanisms depend crucially on the structural peculiarities of the type of drug incorporated into the conjugate. 

The square-planar cisplatin-type structural complexes can be transformed into a polymer constituent in a variety of ways. In the simplest and most straightforward case, it can function as a main chain component, for example, through metal interconnection by a diamine moiety as described in Section Vtll. In a related mode, the metal, incorporated through Pt-N bonds that are not part of the mainchain constituent. Platinum is coordinated by one or two nucleophilic nitrogen donors, generally amino groups, preintroduced into presynthesized carrier polymers. This type of Pt-N anchoring mode is the topic of the present section. 

In the schemes below cleavable bonds, typically of the amide or ester type, are indicated by the symbol //. 

Also included here are structures comprising carriers bearing monoamino side 

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