Biofissionable Pt-N Complexes Anchored through Primary and Secondary Amines

Biofissionable Pt-N Complexes Anchored through Primary and Secondary Amines 

The Pt-N polymer-metal interconnection in the structures covered in the previous section is generally tight-binding and not readily biofissionable. Therefore, in order to achieve faster release of the monomeric bioactive drug complex in the biological environment, the amino groups must be flanked or carrier-interconnected by bonds that are biocleavable and allow hydrolytic or enzymatic backbone or sidechain fragmentation with ultimate liberation of the monomeric complex entity. 

The hterature describes an early investigation which successfully probes the feasibility of platinum anchoring via the 1,2-diamine ligand system. Exploiting the 

Many ringed systems are included in the Howell-Walles patent,including a wide range of nitrogen-containing systems such as piperidones, oxazinidinone, oxa-zolidinone, morpholinone, caprolactam, succinimid, imidazolidinone, cyanuric acid, and hydantoin. 

Along with such complexes, their patent included a wide variety of compounds that contain platinum bound through adjoining aromatic amines. Many of these are based on substituted o-phenylenediamine where the substituting group, Ri, can be an acid, alcohol, sulfonic, or other compoimd that can subsequently be connected to a polymer through a condensation or addition reaction of the complex (31). 

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