Possible Functions

Where does the PS-PLAi come from Northern and western blot analyses indicate the protein is expressed by platelets, skin, lung, and heart in rats. We also found that an inflammation stimulus significantly increased PS-PLAi at both the mRNA and protein levels in various tissues of rat (unpublished observations). These PS-PLAi protein may supply lysoPS to mast cells. Indeed, stimulants such as nerve growth factor, in combination with activated platelets, activate mast cells [30], possibly due to an accumulation of lysoPS on the activated platelets that secrete PS-PLA,. 

The induced PS-PLAi might attack PS-sensitized cells in either an autocrine or paracrine manner. Heparin completely blocked degranulation of a crude mast cell preparation induced by Fc receptor-cross linkers and PS-PI.A, [29]. This indicates that, under normal (heparin-free) conditions, PS-PLAi first anchors to surface he- 

Membrane-associated Phosphatidic Acid-selective Phospholipase A s (mPA-PLAi and mPA-PLA,  

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A stretch-torsion cross term can be used to model the stretching of a bond that occurs in ai eclipsed conformation. Two possible functional forms are ... 

Function. Figure 1 lists several possible functions that can be achieved by crystallization separation, purification, concentration, soHdification, and analysis. A few examples foUow. 

The results of the micromechanics studies of composite materials with unidirectional fibers will be presented as plots of an individual mechanical property versus the fiber-volume fraction. A schematic representation of several possible functional relationships between a property and the fiber-volume fraction is shown in Figure 3-4. In addition, both upper and lower bounds on those functional relationships will be obtained. 

MMPs for therapeutic interventions is complicated by the fact that MMPs are indispensable for normal development and physiology and by their multifunctionality, possible functional redundancy or contradiction, and context-dependent expression and activity. This complexity was revealed by previous efforts to inhibit MMP activity in the treatment of cancer patients that yielded unsatisfactory results. Doxycycline, at subantimicrobial doses, inhibits MMP activity, and has been used in various experimental systems for this purpose. It is used clinically for the treatment of... 

Possible function of polysaccharide-binding plant peroxidases... 

The specific role of organic osmoticum in cultured plant cells remains unclear. Recent results, however, have provided some evidence as to their possible function. Cultured barley embryos were treated with exogenous... 

Structural type. The possible function of flavonoids as antiherbivore defense com-ponnds was discnssed, bnt Mears (1980b) found no correlation between complexity of flavonoid profile and latitnde, as might be the case if complexity of profile increases as one goes from temperate to more tropical climates with concomitant increase in insect predators. Althongh the nnmber of samples stndied was not large, there was a relationship between latitnde and complexity of pigment profiles in taxa restricted to calcareons snbstrates. No driving force for this apparent relationship is evident. 

In short, although the 5-HT system seems to have a rather non-specific influence on overall brain function, in terms of the brain areas to which these neurons project, there is clearly much to be learned about possible functional and spatial specialisations of neurons projecting from different nuclei. 

Jones, RSG (1983) Trace biogenic amines a possible functional role in the CNS. Trends Pharmacol. Sci. 4 426-429. 

Types, Amounts, and Possible Functions of Compounds Released into the Rhizosphere by Soil-Grown Plants... 

The pituitary, as well as the hypothalamic hormones, also contribute to VN development. A transient prolactin receptor (PRLR) is expressed in the late foetal rat. At El8, there is positive staining for this binding protein along the lumenal border the reaction is restricted to the medial (sensory) zone [Freemark et al, Fig. 6(d), 1996]. These sites possibly function in the detection of endogenous lactogenic ligands such as PL-I and PL-II. The VNORs also occupy microvillous sites in this area, but the precise developmental role of PRLR in the early AOS is unknown. The modulatory influence of prolactin is well established after puberty in mammals as a reproductive determinant (Chap. 5). In a more central role, it acts on the EOG recorded from the accessory area of the bulb in newts (Toyoda, 2000). 

Tomiyama T, Shoji A, Kataoka K, Suwa Y, Asano S, Kaneko H, Endo N. Inhibition of amyloid beta protein aggregation neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger. J Biol Chem 1996 271 6839-6844. 

Concerning the nature of the sensor groups at the host molecule, one should aim at binding contacts to the corresponding guest molecule as selective and strong as possible. Functional groups qualified as H-bond mediators meet the requirements... 

We shall now describe the chemistry of those inorganic complexes which are known to have anti-tumour activity in an effort to outline the permutations which such molecules permit and to indicate possible functional modes. We start from the basic observation of Rosenberg (1).Cis [PtCl2 (NH8)d is a very effective anti-tumour drug. Compounds related to it such as trans [PtCl2(NH3)2] are ineffective. Out of a wide range of transition metal complexes tested few have proved to be effective. The successful compounds have certain common features which can be used to circumscribe some of the factors which are probably required for such a drug. 

Hough, L. B. (1988). Cellular localization and possible functions for brain histamine recent progress. Prog. Neurobiol. 30, 469-505. 

Tricoire, H., Moller, M., Chemineau, P. 8r Malpaux, B. (2003). Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod. Reprod. Suppl. 61, 311-21. 

Wada, H., Inagaki, N., Itowi, N. 8r Yamatodani, A. (1991). Histaminergic neuron system in the brain distribution and possible functions. Brain Res. Bull. 27, 367-70. 

Experimentally, the measurement of reaction rates consists in investigating the rate at which starting materials disappear and/or products appear at a particular (constant) temperature, and seeking to relate this to the concentration of one, or all, of the reactants. The reaction may be monitored by a variety of methods, e.g. directly by the removal of aliquots followed by their titrimetric determination, or indirectly by observation of colorimetric, conductimetric, spectroscopic, etc., changes. Whatever method is used the crucial step normally involves matching the crude kinetic data against variable possible functions of concentration, either graphically or by calculation, until a reasonable fit is obtained. Thus for the reaction,... 

Rhoads, M.L. (1984) Secretory cholinesterases of nematodes possible functions in the host-parasite relationship. Tropical Veterinarian 2, 3-10. 

As in previous chapters, to appreciate the use of chemical elements in a new structure, here the brain, the nature of its compartments must be described. The evolution of the brain from the nematode can be traced all the way up to man in its quickly changing construction. No doubt there are lots of possible different arrangements of the zones of the brain but even so a line of ascending organisation can be drawn over a few hundred million years (Fig. 9.4 and Table 9.3). Particular features not stressed so far are the mutual development of the brain nerve and glial cells in zones, the possible functions of the zones (Table 9.4), the position... 

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