Developmental role

The pituitary, as well as the hypothalamic hormones, also contribute to VN development. A transient prolactin receptor (PRLR) is expressed in the late foetal rat. At El8, there is positive staining for this binding protein along the lumenal border the reaction is restricted to the medial (sensory) zone [Freemark et al, Fig. 6(d), 1996]. These sites possibly function in the detection of endogenous lactogenic ligands such as PL-I and PL-II. The VNORs also occupy microvillous sites in this area, but the precise developmental role of PRLR in the early AOS is unknown. The modulatory influence of prolactin is well established after puberty in mammals as a reproductive determinant (Chap. 5). In a more central role, it acts on the EOG recorded from the accessory area of the bulb in newts (Toyoda, 2000). 

Bakkers, J., Semino, C.E., Stroband, H., Kijne, J.W., Robbins, P.W. and Spaink, H.P. (1997) An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish. Proceedings of the National Academy of Sciences USA 94, 7982-7986. 

Lones D,MarkM,Mendehlson C, Dolle P, Decimo D, Chambon P (1995) Developmental roles of the retinoic acid receptors. J Steroid Biochem Mol Biol 53 475... 

Gammie SC, Nelson RJ (1999) Maternal aggression is reduced in neuronal nitric oxide synthase-deficient mice. J Neurosci 19 8027-8035 Caspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin news from mouse molecular genetics. Nat Rev Neurosci 4 1002-1012 Gobbi G, Murphy DL, Lesch K, Blier P (2001) Modifications of the serotonergic system in mice lacking serotonin transporters an in vivo electrophysiological study. J Pharmacol Exp Ther 296 987-995... 

Wistow and Wray have commented on the implications of these strategies for the extent to which management of services should be decentralised, as well as on the capacity of CMHTs to manage support staff without their developmental role once again becoming silted up. 

Gaspar P, Cases O, Maroteaux L. The developmental role of serotonin news from mouse molecular genetics. Nat Rev Neurosci 2003 4 1002-1012. 

McMalion AP, higliam PW, Tabin CJ (2003) Developmental roles and clinical significance of sonic hedgehog signaling. Curr Topic Dev Biol 53 1-114. 

Sellner P, Chu W, Glatz J, Berman NE. Developmental role of fatty acid-binding proteins in mouse brain. Brain Res Developmental Brain Res 1995 89 33 6. 

Veenstra, G.J. andWolffe, A.P. (2001) Gene-selective developmental roles of general transcription factors. Trends Biochem. Sci., 26, 665-671. 

Lohnes, D., Mark, M., Mendelsohn, C., Dolle, P., Decimo, D., LeMeur, M., Dierich, A., Gorry, P., Chambon, P. 1995. Developmental roles of the retinoic acid receptors. J. Steroid Biochem. Mol. Biol. 53, 475 186. 

Pittman, R.N. (1990) Developmental roles of proteases and inhibitors. Semin. Dev. Biol. 1 65-74. 

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