Polycyclic aromatic hydrocarbons toxic

X.-D. Huang, G.D. Dixon, B.M. Greenberg (1995). Increased polycyclic aromatic hydrocarbon toxicity following their photomodification in natural sunlight impacts on the duckweed Lemna gibba L. G-3. Ecotoxicol. Environ. Saf., 32,194-200. 

Agency for Toxic Substances and Disease Registry. 1993a. Polycyclic aromatic hydrocarbon toxicity Environmental medicine. Agency for Toxic Substances and Disease Registry. Am Family Physician 47(3) 623-629. 

Polycyclic Aromatic Hydrocarbons Toxicity IN Animals and Humans... 

Chapter 13 Polycyclic Aromatic Hydrocarbons Toxicity in Animals... 

The synthesis of toxic organic compounds by humans, and their release into the natural environment began to assume significant proportions during the 20th century, especially after the Second World War. Prior to 1900, the chemical industry was relatively small, and the largest chemical impact of humans on the environment was probably dne to the release of hydrocarbons, especially polycyclic aromatic hydrocarbons (PAHs), with the combnstion of coal and other fuels. 

The recommended method of trichloroethylene disposal is incineration after mixing with a combustible fuel (Sittig 1985). Care should be taken to carry out combustion to completion in order to prevent the formation of phosgene (Sjoberg 1952). Other toxic byproducts of incomplete combustion include polycyclic aromatic hydrocarbons and perchloroaromatics (Blankenship et al. 1994 Mulholland et al. 1992). An acid scrubber also must be used to remove the haloacids produced. 

Finlayson-Pitts BJ, IN Pitts (1997) Tropospheric air pollution ozone, airborne toxics, polycyclic aromatic hydrocarbons, and particles. Science 276 1045-1052. 

Sutherland JB, E Rafii, AA Kahn, CE Cerniglia (1995) Mechanisms of polycyclic aromatic hydrocarbon degradation. In Microbial transformation and degradation of toxic organic chemicals (Eds LY Young and CE Cerniglia), pp. 269-306. Wiley-Liss, New York. 

Toxic compounds polychlorinated biphenyls, polycyclic aromatic hydrocarbons, organochlorine pesticides, chlorinated pesticides, dioxins, veterinary drug residues, hormone residues, aflatoxins, toxic compounds in shellfish. Compoimds of nutritional significance in foods vitamins, fat, lipids, carbohydrates, protein, energy-calorific value, proximates, dietary fibre, ash. Other compounds hormones in blood serum... 

Jacinto, M.J., Santos, O., Landers, R., Kiyohara, P.K. and Rossi, L.M. (2009) On the catalytic hydrogenation of polycyclic aromatic hydrocarbons into less toxic compounds by a facile recoverable catalyst. Applied Catalysis B Environmental, 90 (3-4), 688-692. 

Chemicals degraded by WRF include pesticides such as organochlorines DDT and its very toxic metabolite DDE [8, 9] and organophosphate pesticides such as chlorpyrifos, fonofos and terbufos [10] polychlorinated biphenyls (PCBs) of different degrees of chlorine substitution [11-13], some even to mineralization [14, 15] diverse polycyclic aromatic hydrocarbons (PAHs) in liquid media and from contaminated soils or in complex mixtures such as creosote [16-18] components of munition wastes including TNT and its metabolites DNT [19-23], nitroglycerin [24] and RDX [25]. 

Kamlet, M. J., Doherty, R. M., Carr, P. W., Mackay, D., Abraham, M. H., Taft, R. W. (1988) Linear solvation energy relationships. 44. Parameter estimation rules that allow accurate prediction of octanol/water partition coefficients and other solubility and toxicity properties of polychlorinated biphenyls and polycyclic aromatic hydrocarbons. Environ. Sci. Technol. 22, 503-509. 

Govers, H., Ruepert, C., Aiking, H. (1984) Quantitative structure-activity relationships for polycyclic aromatic hydrocarbons Correlation between molecular connectivity, physico-chemical properties, bioconcentration and toxicity in Daphnia pulex. Chemosphere 13, 227-236. 

Herbes, S.E., Southworth, G.R., Shaeffer, D.L., Griest, W.H., Maskarinec, M.P (1980) Critical pathways of polycyclic aromatic hydrocarbons in aquatic environments. In The Scientific Basis of Toxicity Assessment. Witschi, H. Editor, pp. 113-128, Elsevier/North-Holland Biomedical Press, Amsterdam. 

Newsted, J.L., Giesy, J.P. (1987) Predictive models for photoinduced acute toxicity of polycyclic aromatic hydrocarbons to Daphnia magna, Strauss (Cladocera, Crustacea). Environ. Toxicol. Chem. 6, 445 -61. 

Consequently, Europe has historically been a hotspot of environmental pressures because of the contamination caused by agricultural, municipal, and industrial activities and high population densities [5, 6], Such contamination has led to poor water quality in many European river basins [7-12], In addition, this pollution can cause the accumulation in river sediments of toxic compounds such as pesticides [13], surfactants [14], and alkyl polycyclic aromatic hydrocarbons (PAHs) [15], These can in turn act as a source to biota [16] and as a potential risk for entire ecosystems [17] if the compounds bioaccumulate, and thereby enter the food chain [18],... 

Kosian, P.A., E.A. Makynen, P.D. Monson, D.R. Mount, A. Spacie, O.G. Mekenyan, and G.T. Ankley. 1998. Application of toxicity-based fractionation techniques and structure-activity relationship models for the identification of phototoxic polycyclic aromatic hydrocarbons in sediment pore water. Environ. Toxicol. Chem. 17 1021-1033. 

Mezey, P.G., Z. Zimpel, P. Warburton, P.D. Walker, D.G. Irvine, X.D. Huang, D.G. Dixon, and B.M. Greenberg. 1998. Use of quantitative shape-activity relationships to model the photoinduced toxicity of polycyclic aromatic hydrocarbons electron density shape features accurately predict toxicity. Environ. Toxicol. Chem. 17 1207-1215. 

Payne, J.F., J. Kiceniuk, L.L. Fancey, U. Williams, G.L. Fletcher, A. Rahimtula, and B. Fowler. 1988. What is a safe level of polycyclic aromatic hydrocarbons for fish subchronic toxicity study on winter flounder (Pseudopleuronectes americanus). Canad. Jour. Fish. Aquat. Sci. 45 1983-1993. 

U.S. Public Health Service (USPHS). 1995. Toxicological Profile for Polycyclic Aromatic Hydrocarbons (PAHs) (Update). U.S. Dept. Health Human Serv., USPHS, Agen. Toxic Subst. Dis. Regis. 468 pp. 

Yoshikawa, T., L.P. Ruhr, W. Flory, D. Giamalva, D.F. Church, and W.A. Pryor. 1985. Toxicity of polycyclic aromatic hydrocarbons. I. Effect of phenanthrene, pyrene, and their ozonized products on blood chemistry in rats. Toxicol. Appl. Pharmacol. 79 218-226. 

As observed in mammalian models, the immune system of fishes is a sensitive target organ system to evaluate toxicity. For a more thorough review of environmental immunotoxicology in fishes, with reference to specific classes of xenobiotics, readers are referred to several reviews that deal with the subject over a span of nearly three decades [45-47, 54-57], While fish in the environment may be exposed to a variety of xenobiotics, the most frequently investigated xenobiotics are the polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) due to the presence and activation of the aryl hydrocarbon receptor (AhR) in fish, and heavy metals due to their ubiquitous environmental distribution. 

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