Polycyclic aromatic hydrocarbons developmental toxicity

Factorial designs, in which n chemicals are tested at x dose levels (x treatment groups) have been suggested by the US-EPA (US-EPA 1986) as a statistical approach for risk assessment of chemical mixmres. A 2 factorial design has been used to describe interactions between the carcinogenic activity of five polycyclic aromatic hydrocarbons at two dose levels (Nesnow 1994) and a 5 design to identify nonadditive effects of three chemicals on developmental toxicity at five dose levels (Narotsky et al. 1995). 

Polycyclic Aromatic Hydrocarbons Exposure from Emission Products and from Terrorist Attacks on US Targets - Implications for Developmental Central Nervous System Toxicity... 

Incardona, J.P. Day, H.L. CoUier, T.K. Scholz, N.L. 2006. Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism. Toxicology and Applied Pharmacology, v.217, p.308-321. 

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See also in sourсe #XX -- [ ]

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