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Poly ADP-ribose Synthetase

The above described techniques represent an overview of those which would appear to have the most widespread application. For more detail and listings of other techniques the reader should refer to the other reviews in this area (,84, 90, 171, 196, 207, 240). [Pg.11]

Recent attempts at characterization of the poly(ADP-ribose) synthetase have dealt with localization of the enzyme on chromatin, purification and requirements of synthetase for catalytic function, effects of DNA and histones on activity, and the protein substrates of the synthetase. [Pg.11]

This section will review recent developments in these areas. [Pg.11]

Recent studies of eukaryotic chromatin have provided a fairly detailed accoimt of the arrangement of proteins and DNA to form nucleo- [Pg.11]

Repeating units of nucleosome plus linker DNA constitute the polynucleosome, which in turn is involved in higher orders of chromatin structure 50, 63,116,117,123,194). It has been postulated, based on electron micrographs, that polynucleosomes coil into a solenoid with 100 A hole through the central axis 50, 63, 116, 117, 123, 194) one turn of a helix includes 7 to 9 nucleosomes 171). [Pg.12]

Banasik M, Komura H, Shimoyama M, Ueda K (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J Biol Chem 267 1569-1575... [Pg.64]

Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289 2126—2128 Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-148 Mabley JG, Suarez-Pinzon WL, Hasko G, Salzman AL, Rabinovitch A, Kun E, Szabo C (2001) Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-l,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes. Br J Pharmacol 133 909-919... [Pg.67]

Szabo C (1998) Role of poly(ADP-ribose)synthetase in inflammation. Eur J Pharmacol 350 1-19 Tanuma S, Johnson GS (1983) ADP-ribosylation of nonhistone high mobility group proteins in intact cells. J Biol Chem 258 4067-4070... [Pg.68]

Zingarelli B, Salzman AL, Szabo C (1998) Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 83 85-94... [Pg.70]

NAD glycohydrolases from rat liver nuclei, 66, 151 poly(ADP-ribose) synthetase from rat liver nuclei, 66, 154 poly(ADP-ribose) synthetase from calf thymus, 66, 159 extraction and quantitative determination of larger than tetrameric endogenous polyadenosine diphosphoribose from animal tissues, 66, 165 covalent modification of proteins by metabolites of NAD, 66, 168 coenzyme activity of NAD bound to polymer supports through the adenine moiety, 66, 176 use of differently immobilized nucleotides for binding NAD -dependent dehydrogenases, 66, 192. [Pg.503]

OCTANOL DEHYDROGENASE OCTOPINE DEHYDROGENASE PHENYLALANINE DEHYDROGENASE POLY(ADP-RIBOSE) SYNTHETASE (or, SYNTHASE)... [Pg.764]

Zhang J., Dawson V. L., Dawson T. M., and Snyder S. H. (1994). Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263 687-689. [Pg.240]

The biological function of ADP-ribosylated nuclear proteins is not clear. Poly-(ADP-ribose) synthetase has been reported to be stimulated by histones, but histones themselves do not serve as acceptors in vitro (42). The endogenous acceptor iji vivo might involve proteins other than histones. Recently an enzyme that cleaves the ADP-ribosyl histone linkage has been purified from rat liver (43). [Pg.57]

Aoyagi T, et al. Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J. 154. Antibiot. 1988 41 1009-1014. [Pg.183]

Poly (ADP-ribose) synthetase activity during bleomycin-induced lung fibrosis in hamsters. Exp. Mol. Pathol. 43 162-76... [Pg.88]

DNA topoisomerases have been found to be subject to covalent modifications that modulate their DNA-relaxing activities. An example of this is the ADP-ribosylation of calf thymus topoisomerase I by poly(ADP-ribose) synthetase (Ferro et al., 1983 Jongstra-Bilen et al., 1983 Ferro and Olivera, 1984). The modified enzyme is less active in DNA relaxation. The possibility that topoisomerase I and poly(ADP-ribose) synthetase are associated in vivo was suggested by the observation that they copurify (Ferro et al., 1983 Jongstra-Bilen et al., 1983). [Pg.98]

Kameshita, I., Matsuda, Z., Tanigushi, T., Shizuta, Y. (1984). Poly(ADP-ribose)synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA binding domain, and the automodification domain. J. Biol. Chem. 259,4770-4776. [Pg.321]

Virag, L., Scott, G.S., Antal-Szalmas, R, O Connor, M., Ohshima, H., and Szabo, C., Requirement of intracellular calcium mobilization for peroxynitrite-induced poly (ADP-ribose) synthetase activation and cytotoxicity, Molec. Pharmacol, 56, 824, 1999. [Pg.326]

The vast majority of biochemical reactions are catalyzed by enzymes (Bagg, 2004 Copeland, 2000), which are proteins fulfilling all the three criteria of being biocatalysts efficiency (a), specificity (b) and multiple turnover (c). The term enzymes is reserved for the natural catalytic proteins in this text. Although few quasi-catalytic enzymes are known such as type I restriction endonuclease, poly(ADP-ribose) synthetase and transmethylase for 0 -methylguanine mediate specific reactions with large acceleration but are inactivated in the reaction. [Pg.323]

Szabo C, Cuzzocrea S, Zingarelli B ec al. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 1997 100(3) 723-735. [Pg.87]

Mabley JG, Suarez-Pinzon WL, Hasko G et al. Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-l,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes. Br J Pharmacol 2001 133(6) 909-919. [Pg.87]

Szabo C. Role of poly(ADP-ribose)synthetase in inflammation. Eur J Pharmacol 1998 350(1) 1-19. [Pg.90]

Szabo C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998 19(7) 287-298. [Pg.90]

Yoshihara K, Tanigawa Y, Koide SS. Proceedings ADP-ribosylation of Ca 2+, Mg 2+-dependent endonuclease by poly(ADP-ribose) synthetase. J Biochem (Tokyo) 1975 77(1) 10. [Pg.131]

Virag L, Scott GS, Cuzzocrea S et al. Peioxynitrite-induced thymocyte apoptosis The role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology 1998 94(3) 345-355. [Pg.150]

Virag L, Salzman AL, Szabo C. Poly (ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol 1998 161(7) 3753-3759. [Pg.150]

See other pages where Poly ADP-ribose Synthetase is mentioned: [Pg.31]    [Pg.842]    [Pg.992]    [Pg.67]    [Pg.566]    [Pg.566]    [Pg.32]    [Pg.843]    [Pg.324]    [Pg.496]    [Pg.683]    [Pg.683]    [Pg.307]    [Pg.515]    [Pg.330]    [Pg.333]    [Pg.334]   


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