High-mobility group protein

Fig. 5. The NMR-refmed structure of the A-domain of high-mobility group protein 1 (PDBID 1AAB). Adapted from (78).

Szabo C (1998) Role of poly(ADP-ribose)synthetase in inflammation. Eur J Pharmacol 350 1-19 Tanuma S, Johnson GS (1983) ADP-ribosylation of nonhistone high mobility group proteins in intact cells. J Biol Chem 258 4067-4070... 

Rogalla P, Drechsler K, Kazmierczak B, Rippe V, Bonk U, Bullerdiek J (1997) Expression of HMGl-C, a member of the high mobility group protein family, in a subset of breast cancers relationship to histologic grade. Mol Carcinog 19(3) 153-156... 

Henderson A, Bunce M, Siddon N, Reeves R, Tremethick DJ (2000) High-mobility-group protein 1 can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus type 1 proviral promoter. J Virol 74 10523-10534... 

The high-mobility group proteins were initially characterised as prominent components of chromatin [1,17] each mammalian nucleus contains, on average, approximately 10 -10 HMGBl molecules [16,63]. This abundance implies a major chromatin-related function but the precise biological role of the proteins has proved elusive. 

Sheflin, L.G. and Spaulding, S.W. (1989) High mobility group protein 1 preferentially conserves torsion in negatively supercoiled DNA. Biochemistry 28, 5658-5664. 

Payet, D. and Travers, A.A. (1997) The acidic tail of the high mobility group protein HMG-D modulates the structural selectivity of DNA binding. J. Mol. Biol. 266, 66-75. 

Murphy, F.V. 4th, Sweet, R.M., and Churchill, M.E.A. (1999) The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for non-sequence specific DNA recognition EMBO J. 18, 6610-6618. 

Lorenz, M., Hillisch, A., Payet, D., Buttinelli, M., Travers, A., and Diekmann, S. (1999) DNA bending induced by high mobility group proteins studied by fluorescence resonance energy transfer. Biochemistry 38, 12150-12158. 

Ohndorf, U.-M., Rould, M.A., He, Q., Pabo, C.O., and Lippard, S.J. (1999) Basis for recognition of cisplatin-modified DNA by high-mobility group proteins. Nature 399, 708-712. 

Bonne, C., Sautiere, P., Duguet, M., and de Recondo, A.M. (1982) Identification of a single-stranded DNA binding protein from rat liver with high mobility group protein 1. J. Biol. Chem. 257,... 

Pauli, T.T. and Johnson, R.C. (1995) DNA looping by Saccharomyces cerevisiae high mobility group proteins NHP6A/B. Consequences for nucleoprotein complex assembly and chromatin condensation. J. Biol. Chem. 270, 8744-8754. 

Tremethick, D.J. and Drew, H.R. (1993) High mobility group proteins 14 and 17 can space nucleosomes in vitro. J Biol. Chem. 268, 11389-11393. 

Singh, J. and Dixon, G.H. (1990) High mobility group proteins 1 and 2 function as general class II transcription factors. Biochemistry 29, 6295-6302. 

Spencer, J.A., Baron, M.H., and Olson, E.N. (1999) Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRPl. J. Biol. Chem. 274, 15686-15693. 

Ge, H. and Roeder, R.G. (1994) The high mobility group protein HMGl can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J. Biol. Chem. 269, 17136-17140. 

Sutrias-Grau, M., Bianchi, M.E., and Bernues, J. (1999) High mobility group protein 1 interacts specifically with the core domain of human TATA box-binding protein and interferes with transcription factor IIB within the pre-initiation complex. J. Biol. Chem. 274, 1628-1634. 

Yumoto, Y., Shirakawa, H., Yoshida, M., Suwa, A., Watanabe, F, and Teraoka, H. (1998) High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro. J. Biochem. 124, 519-527. 

Sterner, R., Vidali, G., Heituikson, R.L., and Allfrey, V.G. (1978) Postsynthetic modification of high mobility group proteins. Evidence that high mobility group proteins are acetylated. J. Biol. Chem. 253, 7601-7604. 

Renner, U., Ghidelli, S., Schafer, M.A., and Wisniewski, J.R. (2000) Alterations in titer and distribution of high mobility group proteins during embryonic development of Drosophila melanogaster. Biochim. Biophys. Acta 1475, 99-108. 

Peterson, C.L. (1996) Multiple Switches to turn on chromatin Curr. Opin. Genet. Dev. 6, 171-175. Bourachot, B., Yaniv, M., and Muchardt, C. (1999) The activity of mammalian brm/SNF2cr is dependent on a high-mobility-group protein I/Y-like DNA binding domain. Mol. Cell. Biol. 19, 3931-3939. 

Relevance of High-Mobility Group Protein Box 1 to Neurodegeneration Silvia Fossati and Alberto Chiarugi... 

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