Pharmaceutical industry objectives

Solid-phase synthetic methods1,2 feature convenient purification procedures coupled with opportunities for automation.3"5 These attributes have been widely exploited to prepare libraries of small molecules via parallel and combinatorial approaches. A logical extrapolation of these efforts is the supported syntheses of larger, more complex natural products and natural product analogs. Such efforts are consistent with the pharmaceutical industry objectives behind most high-throughput syntheses since, historically, the unique properties of natural products have provided a fertile ground for... 

E Erni, Liquid chromatography-mass spectrometry in the pharmaceutical industry Objectives and needs, J. Chromatogr. 251 (1982), 141-151. 

We will also review the development of chemical metrology in the pharmaceutical industry, an industry that is ever more closely related to molecular biology. The pharmacists first developed quality protocols and reference materials more than 40 years ago, quite independently of the activities of ISO and the REMCO Technical Committee. Only in the closing years of the 20th Century have these two important groups begun to realize that they share common objectives. 

The objective for Medicinal Chemistry is the identification of the chemical structures for potential new medicines. Eventually, these new medicines will be launched into the market to address unmet medical needs and to improve the quality of life for all human beings. The marketing of new medicines is the lifeblood of the pharmaceutical industry. Due to the broad impact Medicinal Chemistry has in the drug discovery process, it is recognized as a top job for synthetic organic chemists. 

The article by Rovira10 stands out for the clarity of its ideas. It sets out an up-to-date description of the pharmaceutical industry and the Spanish market before and after the single market, and its chief merit is its suggestions for a common strategy for the EU. The diagnosis focuses on three points the need for different policies for innovative and non-innovative products, the importance of expected benefits as an incentive for innovation and the existence of conflicts of objectives at national level and between national and EU interests, the solution of which requires compromises of different sorts. 

The collaboration among the above-mentioned groups was intense and admirable. It represented a historic case in which members of the most scientific research teams in government and university laboratories collaborated totally with research scienhsts in the pharmaceutical industry with the objective to (1) determine whether a virus was present in human blood that might transmit this disease and (2) if so, how the products could be treated before use in human patients to eliminate the parasite. Before the end of the decade, researchers at the NIH and the Pasteur Institute in France isolated a virus they called human immunodeficiency virus (HIV), thought to be the cause of AIDS. 

Whereas, however, this objective must be attained by means which will not hinder the development of the pharmaceutical industry or trade in medicinal products within the Community ... 

Griffin JR/s therapeutic conservatism cost effective prescribing European Federation of Pharmaceutical Industries Associations, General Assembly 1993 3rd session Health Objectives and Cost Control. 

Contain cost—since only one in three drugs recovers its cost of development, the pharmaceutical industry needs to find ways to increase the supply of drug candidates while at the same time reduce development costs. Outsourcing to top-tier CROs can accomplish both of these objectives. 

Japan Pharmaceutical Manufacturers Association (JPMA) The key objective of JPMA is the development of a competitive pharmaceutical industry with a greater awareness and understanding of international issues. Over ninety companies are members, including all the major research-based pharmaceutical manufacturers in Japan. ICH work is coordinated through specialized committees of industry experts. JPMA promotes and encourages the adoption of international standards by its member companies. 

The objective of the excipient compatibility screening is to quickly find those excipients/processes that should be avoided for the particular API. In order to obtain a result as rapidly as possible we carry out these studies at elevated temperature as discussed above. The question arises as to how long and at what temperature We need to be able to extrapolate the results to a convenient time frame at 25°C/ 60% RH for ICH Climatic Zones I and II (or 30°C/65% RH for ICH Climatic Zones III and IV). Based on the approximation from the Arrhenius equation (see above) that the reaction rate doubles for a 10°C rise in temperature, we have standard multipliers that have been widely accepted within the pharmaceutical industry. For example, a study carried out at 40° C for one month would equate to three... 

While emphasizing patient care, the general approach used by the CMA policy on Physicians and the Pharmaceutical Industry (CMA 2001) is not inconsistent with that used by the AMA and the ACP. One of the general principles of the CMA policy requires the primary objective of interactions between physicians and industry to be the advancement of health of Canadians rather than the private good of physicians or industry. Another is that relationships with industry are appropriate only insofar as they do not negatively affect the fiduciary nature of the patient-physician relationship. The principles also instruct physicians to resolve any conflict of interest between themselves and their patients resulting from interactions with industry in favor of their patients. They specifically warn physicians to avoid any self-interest in their prescribing and referral practices (CMA 2001). 

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