Pharmaceutical applications biotechnology

Stewart, J.D., Rodriguez, S. and Kayser, M.M. (2001) Cloning, structure, and activity of ketone reductases from baker s yeast. Enzyme Technologies for Pharmaceutical and Biotechnological, Applications 175-207. 

The services are designed to enable the pharmaceutical and biotechnology customers to reduce overall development time and cost. Thus, research and development concentrates one of this company interests and they continuously accept new assignments for development from the private clients. However, they clearly states that the R D results and products will invariably be patented and the application will be rolled out internationally. Prior to commercialization, the developed products are evaluated and tested under controlled conditions with users and industry groups. 

For some recent reviews on the use of enzymes in nonconventional media, see (a) Dreyer, S., Lembrecht, J., Schumacher, J. and Kragl, U., Enzyme catalysis in nonaqueous media past, present, and future in biocatalysis in the pharmaceutical and biotechnology industries, 2007, CRC Press, pp. 791-827 . (b) Torres, S. and Castro, G.R., Non-aqueous biocatalysis in homogeneous solvent systems. Food Technol. BiotechnoL, 2004, 42, 271-277 (c) Carrea, G. and Riva, S., Properties and synthetic applications of enzymes in organic solvent. Angew. Chem. Int. Ed., 2000, 39, 2226-2254. 

Venkitasubramanian, P., Daniels, L. and Rosazza, J.P.N., Biocatalytic reduction of carboxylic acids mechanism and application. In Biocatalysis in the Pharmaceutical and Biotechnology Industries, Patel, R. (ed). CRC Press LLC Boca Raton, FL, 2006, pp. 425-440. 

CEC is a miniaturized separation technique that combines capabilities of both interactive chromatography and CE. In Chapter 17, the theory of CEC and the factors affecting separation, such as the stationary phase and mobile phase, are discussed. The chapter focuses on the preparation of various types of columns used in CEC and describes the progress made in the development of open-tubular, particle-packed, and monolithic columns. The detection techniques in CEC, such as traditional UV detection and improvements made by coupling with more sensitive detectors like mass spectrometry (MS), are also described. Furthermore, some of the applications of CEC in the analysis of pharmaceuticals and biotechnology products are provided. 

Plant Peptide Toxins in Biotechnology and Pharmaceutical Applications... 

E.W. Ciurczak and J.K. Drennen, Pharmaceutical applications of near-infrared-spectroscopy. In Near-Infrared Applications in Biotechnology, R. Raghavachari (ed.), Marcel Dekker Inc., New York, 2001. 

Olson, W.P., Separations technology pharmaceutical and biotechnology applications. 1995, Buffalo Grove, IE Interpharm Press, xix, 505 ill. 

Bioactive peptides can be extracted and purified with these technologies, which vary from simple to complex. Following this, the isolation of bioactive peptides, oligosaccharides, fatty acids, enzymes, water-soluble minerals, and biopolymers for biotechnological and pharmaceutical applications is possible. Further, some of these bioactive peptides have been identified to possess nutraceutical potentials that are beneficial for human health. 

The current or potential industrial applications of microemulsions indude metal working, catalysis, advanced ceramics processing, production of nanostructured materials (see Nanotechnology), dyeing, agrochemicals, cosmetics, foods, pharmaceuticals, and biotechnology (9,12—18). Environmental and human-safety aspects of surfactants have begun to receive considerable attention (19—21). 

G Zhao, TI Meier, WK Yeh. Penicillin-binding proteins as antimicrobial targets expression, purification, and assay technologies. In HA Kirst, WK Yeh, MJZmijew-ski, Jr., eds. Enzyme Technologies for Pharmaceutical and Biotechnological Applications. New York Marcel Dekker, 2001, pp. 263-287. 

A review of capillary electrophoresis applications in pharmaceutical analysis was published in 1993, and the goal of this chapter is to provide an update on the various disciplines within the technique and includes selected applications. Recent developments in the areas of capillary technology, instrumentation, and detection will be reviewed here. Useful strategies for method development involving several classes of pharmaceuticals and biotechnology products will be addressed. The formats within capillary electrophoresis have evolved to such an extent that this chapter is not comprehensive in scope. Therefore, the reader will be directed to other reviews on the various aspects of capillary electrophoresis. Of particular interest to many separation scientists may be a special issue of an Applied Biosystems Newsletter, which addresses the future role of CE, method development in CE, and selected applications in the area of drug analysis and protein separations [7]. 

The German public funded project p-PR aims at the development, supply and testing of a microphotoreactor system in production experiments for chemical, pharmaceutical and biotechnological industry [51]. The reactor will be tested for exemplary applications of fine chemicals and photobiology. 

M.F. Goosen, S.S. Sablani, and R. Roque-Malherbe, in Handbook of Membrane Separations Chemical, Pharmaceutical, and Biotechnological Applications, A.K. Pabby, A.N. Sastre, and S.S. Rizvi, (editors), CRC Press, Boca Raton, FL, 2008, p. 325. 

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