Time development

In an extension of traditional CIDNP methods, Closs and co-workers developed time-resolved CIDNP (TR-CIDNP) m the late 1970s [24, 25 and 26]. The initial time-resolved experiments had a time resolution in the... 

Hyphenated analytical methods usually give rise to iacreased confidence ia results, eaable the handling of more complex samples, improve detectioa limits, and minimi2e method development time. This approach normally results ia iacreased iastmmeatal complexity and cost, iacreased user sophisticatioa, and the need to handle enormous amounts of data. The analytical chemist must, however, remain cogni2ant of the need to use proper analytical procedures ia sample preparatioas to aid ia improved seasitivity and not rely solely on additional iastmmentation to iacrease detection levels. 

The successful separation of xanthate-related compounds by high performance Hquid chromatography (hplc) methods has been reported (91—93). The thin-layer chromatography procedure has been used to determine the nature of the alcohols in a xanthate mixture. A short mn of 3 cm at a development time of 25 min gives a complete separation of C —alkanol xanthates (94). 

Short development time Allocate enough time for development may result in a less than, more time-efficient PEIA techniques complete knowledge of the hazards administrative controls to decide when to go to full scale production Establish minimum requirements transfer package for process knowledge Require development chemist to be present during initial product runs API RP 750 CCPS G-1 CCPS G-10 CCPS G-25... 

Product or Process Development—A company can develop a new product or process as a quasi-research effort with a toller while simultaneously building the in-house production capacity. This allows problems found in the toller s intermediate scale efforts to be fixed in the large-scale process and to reduce development time and costs. It may simply be a case of a company wanting to try new raw materials in a well-known process without disrupting existing production or establishing a pilot facility. Tollers can provide a way to achieve these activities in a parallel fashion. 

Teehniques sueh as FMEA, DFA and Quality Funetion Deployment (QFD) ean enhanee the sueeess of a produet, but alone they will not solve all produet development issues (Andersson, 1994 Jenkins et al., 1997a Kilt et al., 1993). They provide useful aids in the proeess of quality improvement, but they do not ensure produet quality (Andersson, 1994). There exists an important need for DFQ teehniques to aid design and support the produet development proeess (Andreasen and Olesen, 1990). In addition, it has been eited that in order to make further reduetions in produet development time requires new progress in these teehniques (Dertouzos et al., 1989). 

Typically, fixing errors and redesign account for around 30% of product development time, as shown in Figure 5.3, and improving this position provides an opportunity for lead time reduction. This means doing more work early in the process when (Parker, 1997) ... 

The use of CA has proved to be beneficial for companies introducing a new product, when an opportunity exists to use new processes/technologies or when design rules are not widely known. Design conformance problems can be systematically addressed, with potential benefits, including reduced failure costs, shorter product development times and improved supplier dialogue. A number of detailed case studies are used to demonstrate its application at many different levels. 

Development time to produetion f week 8 person-months 5 person-months fO person-months 8 person-months fO person-months 8 person-months ... 

The most important thing to pay attention to in the case of RP phases is the chain length. It is often forgotten, however, that RP phases are available with differing degrees of surface modification and which also differ in their hydrophobicity and wettability and separation behavior (Rf values, development times). These details should, therefore, also be documented. 

Botz et al. (29) also demonstrated, by scanning electron microscopy, that application of overpressure increases the density of the layer, which could be one reason for the higher separation efficiency. These results showed that Empore silica TLC sheets enable extremely rapid separations (5-20 min) in one-dimensional OPLC, and gave good resolution. Theoretically, for a 3-D OPLC separations development times of 15-60 min would be required. The separation cube of sheets could be especially useful for micropreparative separations (30). 

The interests of SMB for performing large-scale separations of enantiopure drugs has been recognized (very short development time, extremely high probability of success, and attractive purification cost) [68]. Several pharmaceutical and fine chemical companies have already developed SMB processes. However, because of strong confidentiality constraints, public information is limited, and some of the major announcements are summarized below ... 

The development time needed for PBAs before a product can be launched into the market is shorter when compared with new materials. 

These so-called Pareto-based techniques do not force consolidation over multiple criteria in advance and aim to return a representation of the set of optimal compounds. They support discussion between team members who may have different views on the downstream impacts of different risk factors perhaps, for example, one team member may know that there is a reliable biomarker for one potential side-effect. This would then mean that assessing this risk need not consume much development time and cost, and the risk factor can have a reduced weighting within the target product profile being evolved by the team. 

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