Pfizer

Not only due to the R05 approach, but also to numerous previous papers in the QSAR field, pioneered by Corwin Hansch, Clog P has become one of the most relevant computed properties when small molecules are initially evaluated and prioritized. In the words of Lombardo et al.-P 

At any rate, due to its wide popularity and the vast availability of literature and in-house data, whether computed or experimentally determined, octanol-water partition or distribution data, remain by far the most utilized single parameter for ADME, QSPR and QSAR predictions. 

Maraviroc was granted regulatory approval in the United States and Europe in 2007 as the first prescribed CCR5 antagonist for the treatment of CCR5-tropic confirmed HIV-1 infection in treatment-experienced patients. Maraviroc is sold under the tradename Selzentry (Celsentri in Europe and Canada) [61]. 

The Pfizer group has also disclosed the structure of a range of distinct CCR5 antagonists 12 related to the Schering compounds depicted below. A combination of 

No further pharmacokinetic or virologic information has been disclosed on these compounds. 

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The development of a new drug is both a time-consuming and a cost-intensive process. It takes 12 to 15 years and costs up to 800 million to bring a new drug to the market. As measured by the market capitalization, the pharmaceutical companies play a pivotal role in the global economy. In February 2003 Pfizer was ranked at position five worldwide, with a market capitalization of 163 billion. Ranking third as far as the market capitalization in Europe is concerned was GlaxoSmithKline, with a current value of 101 billion. Novartis was number five in Europe with 82 billion. 

Polydextrose (Pfizer) is prepared by high temperature polymerization of glucose in the presence of a catalyst. It is a water-soluble, amorphous soUd used primarily as a hulking agent (52). Dried fmit, including pmnes, and dried plum, date, and grape juice is used for similar appUcations (53). 

Lita zein (com protein) Opta Food Ingredients, Pfizer... 

Data for the production and sales of maleic anhydride and fumaric acid ia the United States between 1979 and 1992 are shown ia Table 5. Production of maleic anhydride during this time grew - 2% on average per year. Production of fumaric acid has declined during the same period as customers have switched to the less cosdy maleic anhydride when possible. All production of maleic anhydride in the United States in 1992 was from butane-based plants which used fixed-bed reactor technology as shown in Table 6. The number of fumaric acid producers has been reduced considerably since the early 1980s with only two producers left in the United States in 1992 as shown in Table 6. Pfizer shut down its fumaric acid plant at the end of 1993. However, Bartek of Canada will start up an expanded fumaric acid faciUty to supply the North American market for both their own and Huntsman s requirements. 

Achromycin (Ledede), Panmycin (Upjohn) Sumycia (Squibb), Tetracyn (Pfizer), Tetrex (Bristol), etc... 

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