Pfizer Pharmaceuticals research

Pfizer Specialty Chemical Group, 243 Pharmaceutical Research and Manufacturers of America (PhRMA), 272 Pharmacia Coi"poration, 243 Phelps Dodge Coi"poration, 243... 

I express great appreciation to Drs. John Barrett and Paul McGuirk (Pfizer Central Research) and Dr. Linus Shen (Abbott Pharmaceutical Discovery) for their expert opinions, comments and suggestions concerning this review. 

The industrial production of penicillin by Pfizer in 1943 transformed the chemistry of natural products. Microbiology became its field and pharmaceutical research became its leading trend. The main driving force behind the research of the chemistry of natural products was and still remains to be human health care. Since the advent of antibiotics, many sources of natural chemicals, such as plants, fungi and bacteria, have been searched for antibacterials, anticancer products, immuno-suppressors and chemicals that affect the human psyche. This research was so successful that, even today, more than half of all pharmaceuticals are either natural products or derived from, or inspired by them. The market of antibiotics alone was ca. US 30 billion in 2005. The majority of antibiotics is produced by submerged fermentation of filamentous microorganisms such as soil prokaryotic actinomycetes and eukaryotic moulds, ascomycetes. 

Sabine Schefzick Discovery Technologies, Pfizer Global Research and Development, Ann Arbor, Michigan, USA Dora Schnur Computer Aided Drug Design, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, New Jersey, USA Suzanne K. Schreyer Chemical Computing Group Inc., Montreal, Quebec, Canada... 

This characterization was applied directly to pharmaceutical research during this era. Thus, a former medical director of a division within Pfizer stated in 1960 ... 

Angus Nedderman, Director, Pfizer Global Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Kent, UK Natalia A. Penner, Associate Principal Scientist, Schering-Plough Research Institute, Department of Drug Metabolism and Pharmacokinetics, Kenilworth, NJ Dil M. Ramanathan, Assistant Professor, Kean University, New Jersey Center for Science, Technology Mathematics Education, Union, NJ Ragu Ramanathan, Associate Director, Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Princeton, NJ... 

With 2005 actual spending of 7.4 billion in research development (R D), Pfizer boasts the industry s largest pharmaceutical R D organization Pfizer Global Research and Development. 

Dr. Kevin E. Henegar Pharmaceutical Sciences Pfizer Global Research and Development Eastern Point Rd. 

Pfizer Central Research SmithKline Beecham Pharmaceuticals Strem Chemicals UK... 

Roger C. Adami (75) Pfizer Global Research and Development Division, Pharmaceutical Research and Development Department, Groton, CT 06340... 

The problem of chiral synthesis is critical in making pharmaceuticals. Researchers at GlaxoSmithKline, AstraZeneca and Pfizer have examined 128 syntheses from their own companies and found that as many as half of the drug compounds made by their process R D groups are not only chiral but also each contains an average of two chiral centers [ 15 2]. To meet regulatory requirements, enantiomeric purities of 99.5% were found to be necessary. Biocatalysis is thus an essential tool for pharmaceutical research, and contributes to the development of more sustainable processes. 

Medical Research Laboratories, Pfizer Pharmaceuticals, Groton, Conn. 06340... 

Pfizer Global Research and Development, Sandwich, CT13 9NJ, Kent, UK Pfizer Global Biologies, Pharmaceutical Sciences, Chesterfield, MO 63017 USA... 

Eugene F. Fiese Pharmaceutical Research and Development, Pfizer Central Research, Groton, Connecticut... 

In this program 20 students from predominantly undergraduate institutions were selected to receive 2500 fellowships to conduct research full time, normally during the summer months, with their faculty mentor. For the summer preceding their entrance into graduate school, industrial sponsors offer their awardees the opportunity to work in their corporate research laboratories. These Research Partnerships link student and faculty member with the fellowship sponsor to provide them with an association for mutual identification not otherwise possible. Sponsors in 1990 were American Cyanamid Company (Agricultural Research Division), Eli Lilly and Company, Hewlett-Packard Company, the Merck Company Foundation, Norwich ton Pharmaceuticals, Inc., Pfizer Central Research, Rohm and Haas Company, and SmithKline Beecham Pharmaceuticals. 

Pfizer Central Research Rohm and Haas Company SmithKline Beecham Pharmaceuticals... 

Mary Tanya am Ende Pfizer Central Research, Pharmaceutical Research and Development, Groton, Connecticut 06340. Antonios G. Mikos Cox Laboratory for Biomedical Engineering, Institute of Biosciences and Bioengineering, Department of Chemical Engineering, Rice University, Houston, Texas 77251. 

Essex UK) and more recently with Pfizer Global Research Development (Groton, CT). CI-976 is also commercially available from Tocris Cookson Inc (Ellisville, MO) and Tocris Cookson Ltd (Bristol, UK) (Cat. No. 2227), and material from this source is active in our hands. However, we have not used material from this source. Other ACAT inhibitors were DuP-128 (GlaxoSmithKline) PFK 058 035 (Novartis, Summit, NJ), and TS-962 (Taisho Pharmaceutical Co., LTD, Tokyo, Japan). 

A group of workers at Pfizer Global Research and Development (Alfonsi et al., 2008) have used these principles to draw up a list of solvents in a traffic-light scheme (green = preferred, amber = usable with caution, red = undesirable), together with a list of substitutes for undesirable solvents. They were considering the pharmaceutical industry primarily, but their advice is of general applicability. The... 

Viagra is a trade name marketed by Pfizer Pharmaceutical Company and is chemically sidenafil citrate. Researchers did not start CTeating a drug for impotence. The chemical compound was developed originally for angina (severe but tanporary attack of cardiac pain) and is chemically an inhibitor for an enzyme phosphodiesterase (see the previous section, for example, for the idea of enzyme inhibitor). The drug was not successful in treating heart problems, but many of the test subjects reported their successes in bedroom activity. It turned out that the compound inhibits... 

Pharmaceutical Sciences, Pfizer, Andover, Massachusetts, USA Thomas R. Sharp (59) Pfizer Global Research 8c Development Division, Research Analytical Department, Groton, Connecticut, USA John Steckert (283) Analytical Research 8c Development, BioTherapeutics... 

Chemical Research and Development and Medicinal Chemistry, Pfizer Global Research and Development, La Jolla/Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, CA 92121... 

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