Pfizer Patterns

FIGURE 1.19 XRPD pattern of atorvastatin calcium, Pfizer Form-1, scanned and digitized from the pattern disclosed in US patent 5,969,156. 

Noteworthy in this perspective is the recent work done at Pfizer and Biofocus (see Section 5.5), where, based on analysis of sequence data, mutation data, and physicochemical properties of the ligands, approaches were outlined for discovering sequence patterns characteristic of specific ligand classes. Pfizer applied the approach successfully to the construction of a sequence motif characteristic of monoamine GPCRs [74],... 

Figure 38 (A) Illuminance and (B) Irradiance maps of a chamber showing that the two different lamps do not give the same mapping pattern. Source Courtesy of Jay C. Brumfield and Pfizer Ltd.

FIGURE 12.13 Collision-induced MS/MS spectra of the MH+ ions at mjz 256 and 262 of hydrojg bupropion (solid line) and [ Hg]hydro)9 bupropion (dotted line). Note that the fragment ions do not display the characteristic chlorine isotope pattern because only the higher abundance Cl species was selected for MS/MS. The origin of fragments at mjz 167 and 139 is shown neither retains deuterium atoms present in the internal standard. Data provided by R.L. Walsky and R.S. Obach, Pfizer, New York, NY. 

A prototype pharmacophoric pattern matching system has been installed in the Research Information Services Department, Pfizer Central Research (U.K.), the implementation being in FORTRAN 77 on a VAX 8600 running under VMS. ... 

Jakes et al. implemented these screens in a pharmacophoric pattern matching system that is in use at Pfizer Central Research, U.K. ° It allows distances to be specified as either exact or a range of distances and the atoms to be exact matches or any atom type. In the first stage of the search, the bit map of the file of structures is searched by comparison with the bit map of the query screens. Test searches of 10 published pharmacophoric patterns against a subset of the Cambridge Structural Database demonstrate the effectiveness and the efficiency of screen searching. Specifically, the screen search eliminated, on average, over 95% of the molecules in the daubase. 

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