Petrolatum and lanolin alcohols

Amerchol CAB- Porlan 500 petrolatum and wool alcohols white soft paraffin and lanolin alcohols yellow soft paraffin and lanolin alcohols. 

Petrolatum and lanolin alcohols is a soft solid used in topical pharmaceutical formulations and cosmetics as an ointment base with emollient properties. It is also used in the preparation of creams and lotions. Petrolatum and lanolin alcohols can be used to absorb wound exudates. See Table I. 

Absorption base component Emollient and plasticizer in ointments 

A pale ivory-colored, soft solid with a faint, characteristic sterol odor. 

Microbiological count the total bacterial count, when packaged, is less than 10 per gram of sample. 

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Cholesterol lanolin lanolin, hydrous petrolatum and lanolin alcohols mineral oils. 

Lanolin alcohols mineral oil petrolatum and lanolin alcohols. 

Mineral oil mineral oil light paraffin petrolatum and lanolin alcohols white petrolatum. 

Petrolatum and lanolin alcohols is stable and should be stored in a well-closed container in a cool, dry place. 

Petrolatum and lanolin alcohols is generally regarded as an essentially nontoxic and nonirritant material. However, lanolin alcohols may be irritant to the skin and cause hypersensitivity in some individuals. 

Lanolin and lanolin alcohols are excellent emulsifiers, giving oil-in-water emulsions, and can be combined with additional emulsifiers such as cetearyl alcohol to improve stability.8 The ability of anhydrous lanolin and especially lanolin alcohols to form stable emulsions with up to 300% (w/w) of water distinguishes lanolin from petrolatum in its physical properties.1 The chemical compositions of lanolin and petrolatum are also very different, as petrolatum is composed completely of hydrocarbons.16 Lanolin alcohols and petrolatum can be combined to form cholesterized petrolatum, which also has the capacity to form emulsions. For example, a mixture of 65% (w/w) lanolin, 20% (w/w) water, and 15% (w/w) petrolatum can incorporate an equivalent weight of water without changing its consistency.15,52... 

Nonmedicated ointments are indicated for moderate to severe dry eye, especially with lagophthalmos, persistent inferior corneal stippling, or severe epithelial compromise. Esters of latty acids with long-chain alcohols, such as petrolatum, mineral oil, lanolin, and lanolin alcohols, serve as lubricants and create a lipid layer, retarding evaporation. Although these preparations (Table 14-2) melt at the temperature of the ocular tissue and disperse with the tear fluid, they appear to be retained longer than other ophthalmic vehicles. Because of their molecular... 

Mineral oil and lanolin alcohols light mineral oil paraffin petrolatum. 

Mineral oil mineral oil and lanolin alcohols paraffin petrolatum. 

Chem. Descrip. Petrolatum, lanolin, and lanolin alcohol CAS 8009-03-8, 8006-54-0, 8027-33-6 EINECS/ELINCS 232-373-2,232-348-6,232-430-1... 

Chem. Descrip. Petrolatum, sorbitan sesquioleate, and lanolin alcohol Ionic Nature Nonionic... 

The purity of lanolin and standard tests have been described in the European Pharmacopoeia (EP), in The United States Pharmacopoeia (USP), and according to other national standards.13,14 Lanolin is a semisolid with a melting point of approximately 40 6°C and has a molecular weight in the range of 790 to 880 Da. Lanolin is a complex and variable mixture of mainly esters, diesters, hydroxy esters (87.0-93.5%, w/w),7 8 15 lanolin alcohols (6.0-12.5%, w/w), lanolin acids (<0.5%, w/w), and lanolin hydrocarbons (<1.0%, w/w). The latter are also called paraffins and petrolatum by the EP and USP, respectively.13,14 16-18 Approximately 40% of the esters are a-hydroxy esters. Due to the extremely complex nature of lanolin, the true number of different esters present is unknown. Barnett calculated the theoretical number of monoester combinations from random combinations of 69 aliphatic lanolin alcohols, 6 sterols, and 138 saturated lanolin acids to total 10,350.8 This is most probably an underestimate of the total number of esters, as dibasic acids and dihydric alcohols also occur naturally in lanolin.19 Further combinations of cyclic mono- and di-esters may be formed by dehydration and from inter- and intra-esterification due to heating during the manufacturing process.7 8... 

FIGURE 25.1 Lanolin alcohol (Eucerit , Beiersdorf AG, Hamburg, Germany) reduces skin roughness, as measured by microprofilometry. Lanolin alcohol (2 and 4%, w/w LA) in a water-in-oil cream containing petrolatum was applied twice daily to the volar aspect of the arm. (Adapted from Sauermann, G. and Schreiner, V., The Lanolin Book, Beiersdorf AG, Hamburg, 1999. With permission.)... 

See individual monographs on Lanolin Alcohols, and Petrolatum for further information. 

Cetostearyl alcohol, ethoxylated castor oil, lanolin alcohol, octyldodecanol, and white petrolatum weighed and mixed in the ratio defined above are heated to 60°C. 

Desoximetasone emollient cream 0.25%, desoximetasone gel 0.05%, desoximetasone ointment 0.25%, and desoximetasone emollient cream 0.05% contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Each gram of emollient cream 0.25% contains 2.5 mg desoximetasone in an emollient cream consisting of white petrolatum USP, purified water USP, isopropyl myristate NF, lanolin alcohols NF, mineral oil USP, cetostearyl alcohol NF, aluminum stearate, and magnesium stearate. Each gram of gel 0.05% contains 0.5 mg desoximetasone in a gel consisting of purified water USP, SD alcohol 40 (20%... 

Add diglycol stearate. While heating oil-stearate mix, add cetyl alcohol, lanolin, petrolatum, and polysorbate 40 with mixing. Mix until all are dissolved and temperature of mixture reaches 65°-70°C. 

Cremba. [CrodaInc. CrodaChem.Ud.] Mineral oil, petrolatum, lanolin alcohol, lanolin emoUient moisturizer, and emulsirier for cosmetics and... 

Eucerin is petrolatum with 6% wool alcohols and caused positive patch tests in 1% of 4,354 allergic contact dermatitis patients (Bandmann 1967). Discrepancies were observed between eucerin and lanolin patch tests, explained by differences in allergen concentration... 

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