Ophthalmic vehicles

Therapeutic Function Topical protectant ophthalmic vehicle Chemicel Name Callulose 2-hydroxypropyl ether Common Name Hyprolose Structural Formula ... [Pg.788]

MF Saettone, D Monti, MT Torracca, P Chetoni, B Giannaccini. (1989). Muco-adhesive liquid ophthalmic vehicles—Evaluation of macromolecular ionic complexes of pilocarpine. Drug Dev Ind Pharm 15 2475-2489. [Pg.389]

Saettone, M.F., Monti, D., Torraeea, M.T., and Chetoni, P., Mucoadhesive ophthalmic vehicles evaluation of polymeric low-viscosity formulations, J. Ocul. Pharmacol., 10 83-92... [Pg.191]

A host of bioadhesive controlled release systems have been proposed in recent years. Among the most commonly studied applications of bioadhesive materials is the area of buccal controlled delivery [408], The buccal delivery of small peptides from bioadhesive polymers was studied by Bodde and coworkers [409], and a wide range of compositions based on poly(butyl acrylate) and/or poly(acrylic acid) gave satisfactory performance. Bioadhesive poly(acrylic add)-based formulations have also been used for oral applications [402,410] for the sustained delivery of chlorothiazide [410] and for a thin bioadhesive patch for treatment of gingivitis and periodontal disease [411]. Other bioadhesive applications of polyelectrolytes include materials for ophthalmic vehicles [412,413], and systems for oral [410,414,415-419], rectal [420,421] vaginal [422] and nasal [423] drug delivery. [Pg.35]

Preparation and evaluation of a sustained release ophthalmic vehicle for 161... [Pg.7]

Vandamme, T.F., and L. Brobeck. 2005. Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. J Control Release 20 102. [Pg.521]

Saettone, M. F., Chetoni, P.,Tilde Torracca, M., Burgalassi, S., and Giannaccini, B. (1989), Evaluation of muco-adhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid, Int. I. Pharm., 51(3), 203-212. [Pg.757]

Rozier, A., Mazuel, C., Grove, J., and Plazonnet, B. (1989), Gelrite(R) A novel, ion-activated, in-situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol, Int. J. Pharm., 57(2), 163-168. [Pg.758]

Rozier A, Mazuel C, Grove J, et al. Gelrite a novel ion-activated, in-sim geUing polymer for ophthalmic vehicles. Effect on bioavailabUity of timolol. Int J Pharmacol 1989 57 163-168. [Pg.38]

Nonmedicated ointments are indicated for moderate to severe dry eye, especially with lagophthalmos, persistent inferior corneal stippling, or severe epithelial compromise. Esters of latty acids with long-chain alcohols, such as petrolatum, mineral oil, lanolin, and lanolin alcohols, serve as lubricants and create a lipid layer, retarding evaporation. Although these preparations (Table 14-2) melt at the temperature of the ocular tissue and disperse with the tear fluid, they appear to be retained longer than other ophthalmic vehicles. Because of their molecular... [Pg.272]

Krishna N, Brow F. Polyvinyl alcohol as an ophthalmic vehicle effect on regeneration of corneal epithehum. Am J Ophthalmol 1964 57 99-106. [Pg.277]

Nom MS, Opauszki A. Effects of ophthalmic vehicles on the stabRity of the precorneal film. Acta Ophthalmol 1977 55 23-34. [Pg.277]

Unlii N, Ludwig A, van Ooteghem M, et al. Formulation of carbopol 940 ophthalmic vehicles, and in vitro evaluation of the influence of simulated lacrimal fluid on their physico-chemical properties. Pharmazie 1991 46 784-788. [Pg.114]

Carmignani C, Rossi S, Saettone ME, Burgalassi S. Ophthalmic vehicles containing polymer-solubilized tropicamide in vitro—in vivo evaluation. Drug Dev Ind Pharm 2002 28 101-105. [Pg.578]

Cationic polymers were probably superior mucoadhesives due to the ability to develop molecular attraction forces by electrostatic interactions with the negative charges of the mucus the polyca-tionic chitosan was investigated as an ophthalmic vehicle. The polymer is biodegradable, biocompatible, and non-toxic. It possesses antimicrobial and wound-healing properties. Moreover, chitosan exhibits a pseudoplastic and viscoelastic behavior. ... [Pg.1212]

Besides chitosan, numerous polysaccharides were evaluated as mucoadhesive ophthalmic vehicles polygalacturonic acid, xyloglucan, xanthan gum, gellan gum, pullulan, guar gum, scleroglu-can, and carrageenan. [Pg.1213]

In the recent years, several types of solid ophthalmic vehicles (inserts) have been developed. These are intended for a direct application into the conjunctival sac, and can be basically categorized... [Pg.187]

Camber O, Edman P. Sodium hyaluronate as an ophthalmic vehicle - some factors governing its effect on the ocular absorption of pilocarpine. CurrEye Res 1989 8 563-567. Cantor JO, Cerreta JM, Armand G, Turino GM. Aerosolized hyaluronic acid decreases alveolar injury induced by human neutrophil elastase. Proc Soc Exp Biol Med 1998 217 471 75. [Pg.136]

Saettone M F, Giannaccini B, Chetoni P, et al. Evaluation of highmolecular- weight and low-molecular-weight fractions of sodium hyaluronate and an ionic complex as adjuvants for topical ophthalmic vehicles containing pilocarpine. IntJPharm 1991 72 131-139. [Pg.141]

Saettone M F, Monti D, Torracca M T, Chetoni P. Mucoadhesive ophthalmic vehicles - evaluation polymeric low-viscosity formulations. J Ocul Pharmacol 1994 10 83-92. [Pg.141]

Active investigations on potentially mucoadhesive polymers as ingredients for ophthalmic vehicles are underway in many laboratories, and hopefully they will eventually lead to the development of more efficient ocular delivery systems. [Pg.117]

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