P chloro

Ihese relative probabilities can be easily determined by simply counting the number c imes during the simulation that the relevant value of lambda reaches unity. In the case ( the para-substituted benzamidines it was possible after only a relatively short simulatio (110 po) to observe that the p-chloro and p-methyl derivatives were significantly weaki than the p-amino and the parent compound (Figure 11.18). In this particular case, all foe... 

Propiophcnone Benzyl methyl ketone Benzyl ethyl, Benzophenone. p Chloro- ... 

Prepare p-chlorobenzoyl chloride by refluxing and stirring 78 g. of p-chloro-benzoic acid (Section IV,157) and 100 g. of redistilled thionyl chloride until solution is complete. Distil off the excess of thionyl chloride at atmospheric pressure and then the acid chloride under reduced pressure 70 g. of product, b.p. 119-120°/ 22 mm., m.p. 14-15°. are obtained. 

For the nine substituents m- andp-methyl, p-fluoro, m- and p-chloro, m- and p-bromo, and m- and p-iodo, using the results for nitration carried out at 25 °C in nitromethane or acetic anhydride - (see tables 9.1, 9.5), a plot of logjoA/ j against cr+ produced a substituent constant p = —6-53 with a standard deviation from the regression line i = 0-335, 2 correlation coefficient c = 0-975. Inclusion of... 

Cm.OROCARBONSANDCm.OROHYDROCARBONS - BENZYL CTD ORIDE, BENZAL CTD ORIDE AND BENZOTRICm ORIDE] (Vol 6) p-Chloro-m-xylenol [88-04-0]... 

PyraZolines. l,3-Diphenyl-2-pyia2olines (7) (Table 2) aie obtainable from appiopiiately substituted phenyUiydiazines by the Knoii reaction with either P-chloro- or P-dimethylaminopropiophenones (30,31). They are employed for brightening synthetic fibers such as polyamides, cellulose acetates, and polyacrylonitriles. 

Acetic acid Acrylic acid Adipic acid Benzene Biphenyl Bisphenol-A Caprolactam Chloroacetic acid p-Chloro toluene p-Cresol... 

Acetanilide, p-chloro-acetanilide, 2,5-dichloro-acetanilide Apply sample solution and treat with chlorine vapor in the trough chamber for 20 s, then heat to 60°Cfor 5 min in a ventilated drying cupboard. Various chlorination patterns are produced. [44]... 

The Fiesselmann reaction has been extensively used with p-halovinyl esters, ketones,aldehydes and nitriles as reaction partners for thioglycolic acid and its derivatives. This reaction with P-halovinyl aldehydes has been extensively explored as a result of the availability of P-chloro-a,P-unsaturated aldehydes via the Vilsmeier... 

This reaction has recently been exploited for the synthesis of 2,3-diarylthiophenes. Thus, P-chloro-a,p-unsaturated aldehyde 19 underwent reaction with ethylthioglycolate to produce 20. The production of 20 by this method enabled the synthesis of a number of derivatives for investigations of their use as anti-inflammatory agents. 

Radicaloid substitution has not been extensively studied in the thiophene series. Molecular orbital calculations indicate that substitution should occur in the a-position. This has been found to be the case in the Gomberg-Bachmann coupling of diazohydroxides with thiophenes which has been used for the preparation of 2-(o-nitro-phenyl) thiophene, 2-(p-toluyl) thiophene, " " and 2-(p-chloro-phenyl)thiophene. " Coupling in the /8-position has been used for the preparation of 1,3-dimethyl-4,5-benzisothionaphthene (148) from 2-amino-tt-(2,5-dimethyl-3-thienyl)cinnamic acid (149). A recent investigation describes the homolytic phenylation of 2- and 3-phenyl-... 

Besides acetophenone, this reaction was also applied to p-chloro- andp-methoxyacetophenone, and even to an aliphatic ketone, acetone (although the yield was stated to be only half as large as that obtained from mesityl oxide, i.e., less than 30%, Dorofeenko and co-workers reported a 45% yield of 2,4,6-trimethylpyrylium perchlorate from acetone, acetic anhydride, and perchloric acid), and is the standard method for preparing pyrylium salts with identical substituents in positions 2 and 4. The acylating agent may be an anhydride in the presence of anhydrous or hydrated ferric chloride, or of boron fluoride, or the acid chloride with ferric chloride.Schneider and co-workers ... 

There is an early report that thiophene reacts at the 3-position in phenylation with benzenediazonium chloride and aluminum trichloride, but in the Gomberg reaction thiophene has been found to substitute mainly at the 2-position both with p-tolyl and with p-chloro-phenyl radicals.Bcnzothiazole is phenylated at the 2-position in low yield by dibenzoyl peroxide a small quantity of the 4-isomcr is also obtained. ... 

Alkylation of the p-chloro analog (102) of the monosubsti-tuted piperazine with m-methylbenzyl chloride (103) yields the... 

The p-chloro analog of phentermine has much the same activity as the parent compound, with perhaps a somewhat decreased activity on the central nervous system. Alkylation of p-chloro-benzyl chloride with the carbanion obtained from treatment of 2-nitropropane with strong base affords the compound containing the required carbon skeleton (74). Catalytic reduction of the nitro group yields chlorphentermine (75). ... 

Schiff s base (j ) derived by reaction of p-chloro-anil ine and borohydride followed by acylation with phenylacetyl chloride produces amide 22,. Selective hydrolysis with HBr followed by alkylation with isopropyl bromide completes the synthesis of lorcainide (20). ... 

The mixture is refluxed with stirring for ten hours, cooled and filtered. The filtrate is extracted three timas with 200 cc portions of 6 N acetic acid. The aqueous acetic acid solution is then made strongly basic with 10% sodium hydroxide solution, and extracted three times with 200 cc portions of ether. The ether extract is dried with anhydrous sodium sulfate, stirred with 5 g of activated carbon and filtered to provide 2-[p-chloro-a(2-di-methylaminoethoxylbenzyll pyridine in solution. Addition of a solution of 116 g (1 mol) of maleic acid in 1,500 cc of ether gives 323 g (79%) of solid which, on recrystallization from ethyl acetate, gives white solid 2-[p-chloro-a(2-dimethvlaminoethoxv)benzyl] pyridine maleate melting at 117° to 119°C. 

A solution of 54 g (0.64 mol) of propyl isocyanate in 60 ml of anhydrous dimethylform-amide was added to a cold, well-stirred suspension of 81 g (0.42 mol) of dry p-chloro-benzenesulfonamide in 210 ml of anhydrous triethylamine during the course of 20 to 30 minutes. The mildly exothermic reaction was completed by allowing it to stand at room temperature for about 5 hours. The reaction mixture was then slowly added to 3 liters of cold 20% acetic acid during the course of about one hour, constant agitation being maintained throughout the addition. 

Chemical Name 1 -[2-[(p-chloro-a-phenylben2yl)oxyl ethyl) piperidine Common Name —... 

The manufacture of a related compound is first described. 28.1 parts of p-chloro-benzhy-dryl bromide are heated to boiling, under reflux and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of calcined sodium carbonate. The reaction product is extracted with ether and the ethereal solution washed with water and dilute hydrochloric acid. The residue from the solution in ether boils at 134° to 137°C under 0.2 mm pressure and is p-chloro-benzhydryl-(/3-chloroethyl) ether. 

If 18 parts of piperidine are used instead of 12 parts of methylethylamine then the same procedure results in the formation of p-chloro-benzyhydril-(/3-piperidino-ethyl) ether, boiling at 178° to 180°C under 0.15 mm pressure. 

Chemical Name 2-[2-[2-[4-(p-chloro-a -phenylben2yl)-1-pipera2inyl] ethoxy] ethoxy] ethanol... 

One route is described in U.S. Patent 3,412,193 as follows. To a mixture of o-(p-chloro-phenoxy)aniline hydrochloride (prepared from 32 g of the base) in 50 ml of pyridine is added gradually while heating under reflux, 25 ml of ethyl chloroformate. After the addition is completed, the mixture is heated under reflux for one hour longer, and then evaporated under reduced pressue to an oily residue. The residue is taken up in 300 ml of water, and extracted with ether (approximately 200 ml). 

A solution of 200 g of 1 -p-chlorophenvl-2-phenyl-4-(N-pvrrolidino)-butanol-2 in 750 ml of concentrated hydrochloric acid is refluxed for 9 hours thereby causing a dehydration of the butanol compound, and the formation of the hydrochloric acid addition salt of a 1 -p-chloro-phenyl-2-phenyl-4-(N-pyrrolidino)-butene. The hydrochloride salt formed crystallizes in the oily lower layer of the two phase reaction mixture and is removed therefrom by filtration. The filtrate is again refluxed for 9 hours, cooled to0°C,and a second crop of the hydrochloric acid addition salt of the dehydration product is obtained and filtered off. The filtrate containing residual amounts of 1 -p-chlorophenyl-2-phenyl-4-(N-pyrrolidino)-butanol-2 is again refluxed for 9 hours to yield an additional crop of the salt of the dehydration product. The several fractions of the butene compound are combined and triturated with several small portions of hot acetone and recrystallized from alcohol-ether mixture. The hydrochl or ic acid addition salt of the dehydration product, 1 -p-chlorophenyl-2-phenyl-4-(N-pyrrolidino)-butene hydrochloride, melts at about 227°C to 228°C. 

Phenol 2,4,6-trichlorophenol p-chloro-m-cresol 2-chlorophe-nol 2,4-dichlorophenol 2,4,-dimethylphenol 2-nitrophenol 4-nitrophenol 2,4-dinitrophenol and pentachlorophenol... 

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