P-Chloro-phenol

Chlorophenyl trifluoromethanesulfonate Methanesulfonic acid, trifluoro-,j-chlorophenyl ester (8) Methanesulfonic acid, trifluoro-, 4-chlorophenyl ester (9) (29540-84-9) 4-Chlorophenol TOXIC Phenol, p-chloro- (8) Phenol, 4-chloro- (9) (106-48-9) Pyridine (8, 9) (110-86-1)... 

Synonyms p-Chlorophenol 4-Hydroxychlorobenzene Parachlorophenol PCP Phenol, p-chloro-... 

Phenol, o-(t-butyl)-. See 2-t-Butylphenol Phenol, 2-s-butyl-4,6-dinitro-, ammonium salt. See 4,6-Dinitro-o-s-butylphenol ammonium salt Phenol, p-t-butyl-, phosphate (3 1). SeeTris (p-t-butylphenyl) phosphate Phenolcarbinol. See Benzyl alcohol Phenol, 2-chloro-. See 2-Chlorophenol Phenol, p-chloro-. See4-Chlorophenol Phenol, 2-(5-chloro-2H-benzo-triazol-2-yl)-4,6-bis (1,1-dimethylethyl)-. See 2-(3, 5 -Di-t-butyl-2 -hydroxyphenyl)-5-chlorobenzotri azole Phenol, 4-chloro-2-benzyl-. See Chlorophene Phenol, 4-chloro-5-methyl-2-(1 -methylethyl)-. 

Halogenation of phenol also leads to phenol derivatives which are much more effective than the starting substance. At the same time, the dissociation constant increases with an increase in the number of halogen atoms, i.e. the acidic character of the phenol derivatives becomes more distinctive. The combination of alkylation and halogenation (the latter with preference in the p-position) has led to microbicides which have attained great practical significance as substances for the protection of materials and disinfection, e.g. p-chloro-o-benzyl phenol, p-chloro-m-cresol, p-chloro-/M-xylenol. 

Chloro-3-methyl-phenol — p-Chloro-m-cresol (PCMC)... 

Phenol 2,4,6-trichlorophenol p-chloro-m-cresol 2-chlorophe-nol 2,4-dichlorophenol 2,4,-dimethylphenol 2-nitrophenol 4-nitrophenol 2,4-dinitrophenol and pentachlorophenol... 

Phenolic biocides are still used extensively throughout the Figure 4 PCMC metalworking industry to preserve aqueous based metalworking fluids. One of the most commonly used phenolic biocides is p-chloro-m-cresol, (see PCMC, Figure 4). 

Nikitin, B. A. and Ioffe, E. M., A Compound of Radon with p-Chloro-phenol, Doklad. Akad. Nauk. SSSR 85 809-10 (1952). 

Synonyms AI3-00075 Aptal Baktol Baktolan BRN 1237629 Candaseptic Caswell No. 185A CCRIS 1938 p-Chlor-/ 3-cresol Chlorocresol 4-Chlorocresol p-Chlorocresol 4-Chloro-/ 3-cresol 6-Chloro-/ 3-cresol 4-Chloro-l-hydroxy-3-methylbenzene 2-Chlorohydroxytoluene 2-Chloro-5-hydroxytoluene 4-Chloro-3-hydroxytoluene 6-Chloro-3-hydroxytoluene 4-Chloro-3-methyl-phenol /5-Chloro-3-methylphenol CMK EINECS 200-431-6 EPA pesticide chemical code 064206 3-Methyl-4-chlorophenol NSC 4146 Ottafact Parmetol Parol PCMC Peritonan Preventol CMK Raschit Raschit K Rasenanicon RCRA waste number U039 UN 2669. 

This reaction is specially interesting since many of the above compounds readily yield the corresponding anthraquinone derivatives (see p. 82), e.g., 4-chloro-l-hydroxy-anthraquinone has been obtained from p-chloro-phenol substituted anthraquinones of this type are becoming increasingly important. 

Another case of major enantiomer separation occurs when helical tubuland diols (Section 3.2.1) are crystallised with small phenol molecules and intimately hydrogen bonded co-crystals are produced. A typical example is (11 ) ( p-chloro-phenol) [33], The major supramolecular synthon is H-0 H-0 H-0 hydrogen bonding with eclipsed stacks of the participating molecules surrounding a pseudo-threefold screw axis (Figure 13). This chiral motif involves molecules of p-chloroplienol and only one of the enantiomers of 11. 

Yang HH, Eckert CA. Homogeneous catalysis in the oxidation of p-chloro-phenol in supercritical water. Ind Eng Chem Res 1988 27 2009-2014. 

The synthesis route is by reaction of bromopinacolone with p.chloro phenol, followed by bromination and reaction with triazole... 

Negative substituents enhance the acidic properties of phenols, an effect opposite to that produced with aromatic amines. o and p-Chloro-phenols are considerably stronger acids than phenol itself, and o- and p-nitrophenols are still stronger. Trinitrophenol, picric acid, is a strong acid whose salts are neutral and not decomposed by carbonic acid or by ammonium salts. These salts of picric acid can be salted out of neutral solutions by sodium or potassium chloride. With negatively substituted phenols, it may be possible to separate the phenolate from solutions which are neutral or weakly alkaline to litmus. In doubtful cases, just as with the amines, the precipitated material must be studied to determine whether it is the free phenol or one of its salts. The color of the precipitate gives an indication in the case of the nitrophenols, since the free phenols have only a weak yellow color, whereas the alkali salts are deep yellow. Solubility tests with indififerent solvents may be used in the case of uncolored compounds. Only the free phenol can be separated from acidic solutions. 

SYNS p-CHLORFENOL (CZECH) p-CHLOROPHENOL PARACHLOROPHENOL PHENOL, 4-CHLORO-... 

SYNS BENZYTOL 4-CHLORO-3.5-DIMETHYL-PHENOL CHLORO-XYLENOL p-CHLORO-m-XYLENOL DESSON DETTOL ESPADOL HUSEPT EXTRA OTTASEPT OTTASEPT EXTRA PCMX RBA 777... 

SYNS 2-BENZYL-4-CHLOROPHENOL, SODIUM SALT 4-CHLORO-2-(PHENYLMETHYI.)PHENOL SODIUM SALT PHENOL, 4-CHLORO-2-(PHENYLMETHYL)-, SODIUM SALT SODIUM o-BENZYL-p-CHLOROPHENOLATE... 

Figure 18.12 Systematic optimization of the separation often phenols (reproduced by permission of Du Pont). Peaks 1 = phenol 2 = p-nitrophenol 3 = 2,4-dinitrophenol 4— o-chlorophenol 5— o-nitrophenol 6 = 2,4-dimethylphenol 7 = 4,6-dinitro-o-cresol S p-chloro-m-cresol 9 = 2,4-dichlorophenol 10 = 2,4, 6-trichlorophenol.

Preparation. The reagent is prepared i n 81 % yield by the reaction of p-chloro-phenol in 1 N NaOH solution with thiophosgene in chloroform.1... 

Other Studies. - The P NMR chemical shifts of alcohols, carboxylic acids and phenols phosphitylated with 2-chloro-4,4,5,5-tetramethyl-dioxaphospholane have been correlated with substituent effects of phenols. P NMR spectroscopy has also been used to study activation pathways of aryl H-phosphonate ester condensation reactions, the conversion of allenyl and divinyl phosphines to 1- and 2-phosphadienes, the reaction of tetraphosphorus decasulfide with dialkyl disulfides, the reaction of phosphine with cyclic olefins, the chemical shift tensors of powder samples of phosphole derivatives, the reactions of alcohols and mercaptans with tetraphosphorus trichalcogen diiodides, the structure of aminomethanebisphosphonic acids, and reactions of 00-di-(2-ethylhexyl)dithiophosphoric acids. ... 

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