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2.4- dichloro-2- -acetanilide

Acetanilide, p-chloro-acetanilide, 2,5-dichloro-acetanilide Apply sample solution and treat with chlorine vapor in the trough chamber for 20 s, then heat to 60°Cfor 5 min in a ventilated drying cupboard. Various chlorination patterns are produced. [44]... [Pg.65]

Diloxanide furoate is the furoate ester of 2,3-dichloro-4-hydroxy-A-methyl acetanilide. This antiamoebic drug was developed as a result of the discovery that various a,a-dichloroacetamides possessed an amoebicidal activity [1]. Diloxanide furoate is considered as a safe and effective drug for the treatment of asymptotic or mildly symptomatic persons who are passing cysts of Entameba histolytica [2,3], It acts principally in the bowel lumen, and is used in the treatment of the intestinal amoebiasis. It is less effective in amebic dysentery than in asymptotic infection, but the furoate gives high intestinal concentrations and is possibly more effective than metronidazole in the treatment of cyst passers [4],... [Pg.251]

It of interest to note that the isobutyl group may also be replaced by a heterocyclic ring. The route to this compound, pirprofen (51-6), starts with the direct methylation of unesterihed 4-nitrophenylacetic acid (51-1). The observed selectivity for monoalkylation in this case may reside in the structure of the dianion, whose most stable form is presumably that depicted in (51-2). Catalytic reduction of the product (51-3) gives the corresponding aniline this is then converted to its acetanilide (51-4) with acetic anhydride. Treatment with chlorine followed by hydrolysis gives the chloroaniline (51-5). Double alkylation of this last intermediate with 1,4-dichloro-but-2-ene (depicted as the cis isomer for aesthetic reasons) forms the dihydropyrrole ring. There is thus obtained the NSAID pirprofen (51-6) [52]. [Pg.77]

Activity on cell proliferation is maintained when a major part of the side chain is replaced by an amide linkage. The tetralin-based compound tamibarotene (15-7) has been tested as an agent for treating leukemias. Reaction of the diol (15-1) with hydrogen chloride affords the corresponding dichloro derivative (15-2). Aluminum chloride-mediated Friedel-Crafts alkylation of acetanilide with the dichloride affords the methylated tetralin (15-3). Basic hydrolysis then leads to the primary... [Pg.99]

It is known that many environmental endocrine-disrupting chemicals have weak estrogenic or antiestrogenic activity [111], or they act as androgens (e.g. tributyltin) or possess antiandrogenic activities (e.g. linuron, 3,4-dichloro-acetanilide etc.). Some chemicals can block the effects of male sex hormones, the androgens [112, 113, 115f]. These special chemicals are described in the next sections. [Pg.33]

Nitroglycerine, diethyl phthalate, ethyl centralite, acetanilide Adsorption Vyadac 1, 1-dichloro-ethane... [Pg.237]

The herbicides N-(3,4-dichloro-phenyl) propionamide (Propanil), N-(3,4-dichlorophenyl) methylacryl amide (Diciyl), and N-(3,4-dichloro-phenyl)-2-methylpentanamide (Karsil) were transformed into 3,4-dichloroaniline [222-225]. The a[Pg.22]

Acetamide, N-(p-hydroxybenzyl)-, 41 Acetanilide, 58 Acetic acid, diphenyl-, 50 Acetoacetic acid, 31 Acetoin, 37 Acetone, acetyl-, 39 dichloro-, 39 dihydroxy-, 31 Acetophenone, 52, 54 o-amino-, 55... [Pg.99]


See other pages where 2.4- dichloro-2- -acetanilide is mentioned: [Pg.40]    [Pg.672]    [Pg.1120]    [Pg.1621]    [Pg.425]    [Pg.425]    [Pg.76]    [Pg.40]    [Pg.827]    [Pg.50]   
See also in sourсe #XX -- [ Pg.65 ]




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