Operations metrics

Finally, the registration stability batches were manufactured within a 6-month time period of transfer initiation. During the entire transfer process the marketed product had to have uninterrupted commercial supply, with minimal impact on the regulatory file (Anon, 2012). The product was subsequently manufactured at the production facility for a further 6-years, with good operating metrics (>95% on-time-in-full metrics). 

Operational metrics must be developed that will facilitate the assessment of the effects of sleep loss and fatigue on key outcomes such as patient health and safety, education effectiveness, resident health and professionalism, and health care economics. (See Table 1.)... 

In one example, a manufacturer of medical devices, partnering at this level with key suppliers on design, implementation, and customization of solutions directed toward specific key customers resulted in dramatic improvements. Cycle times were reduced from 60 to 88 days to a range of 8 to 19 days, with an average of 15. There was significant quality improvement and new operational metrics have led to industry best standards. 

If you have a conversation with the finance department or on Wall Street, you will hear different views of what value means. The definition of value from a finance person would include, of course, money. Within this book, we will begin to understand different perspectives on what value means and show how supply chain management and operations affect an organization s financial performance. In the next chapter, we will discuss the monetary value of a firm in greater depth, but for now, taken together, firm value includes ROIC, growth rate, and cost of capital. It is incredibly beneficial for supply chain professionals to understand how these factors are affected by supply chain activities. In the end, you will not only know how operational metrics are affected by your decisions but you will also grasp how financial metrics are influenced by your decisions. 

For companies already struggling to meet the demands to provide sustainability and other operational data, the financial market s increasing interest in operating information may seem like just another burdensome effort and expense. In reality, it is an enormous opportunity. Financial numbers are strong short-term performance indicators, but they do not always tell the full story. To the trained eye, nonfinancial operational metrics can help complete the narrative, especially when it comes to projecting mid-to long-term performance. 

Today, information technology is driving advances in companies ability to aggregate information and data across all these silos to help create integrated management systems. Although corporate executives and their boards of directors are now able to compare operational performance across a variety of operational metrics, efforts continue to collate, compile, and prioritize the information. Some of this is done through the establishments of dashboards and KPIs and this is just one manner in which executives raise the bar on performance. 

We can now proceed to the generation of conformations. First, random values are assigne to all the interatomic distances between the upper and lower bounds to give a trial distam matrix. This distance matrix is now subjected to a process called embedding, in which tl distance space representation of the conformation is converted to a set of atomic Cartesic coordinates by performing a series of matrix operations. We calculate the metric matrix, each of whose elements (i, j) is equal to the scalar product of the vectors from the orig to atoms i and j ... 

U.S. chlorine trifluoride production is several metric tons per year. Most of the product is used in nuclear fuel processing. A large production plant for chlorine trifluoride was operated in Germany during World War II with a reported capacity of 5 t/d (106,107). As of 1993, Air Products and Chemicals, Inc. was the only U.S. producer. The 1992 price was ca 100/kg. 

An example of a modem, tangentially fired, supercritical, lignite-fuel furnace is shown in Figure 5. This unit, at maximum continuous ratings, supplies 2450 metric tons pet hour superheat steam at 26.6 MPa (3850 psi) and 544°C, and 2160 t/h reheat steam at 5.32 MPa (772 psi) and 541°C. These ate the values at the superheater and reheater oudet, respectively. Supercritical fluid-pressure installations ate, however, only rarely needed. Most power plants operate at subcritical pressures in the range of 12.4—19.3 MPa (1800—2800 psi). 

The unit Kureha operated at Nakoso to process 120,000 metric tons per year of naphtha produces a mix of acetylene and ethylene at a 1 1 ratio. Kureha s development work was directed toward producing ethylene from cmde oil. Their work showed that at extreme operating conditions, 2000°C and short residence time, appreciable acetylene production was possible. In the process, cmde oil or naphtha is sprayed with superheated steam into the specially designed reactor. The steam is superheated to 2000°C in refractory lined, pebble bed regenerative-type heaters. A pair of the heaters are used with countercurrent flows of combustion gas and steam to alternately heat the refractory and produce the superheated steam. In addition to the acetylene and ethylene products, the process produces a variety of by-products including pitch, tars, and oils rich in naphthalene. One of the important attributes of this type of reactor is its abiUty to produce variable quantities of ethylene as a coproduct by dropping the reaction temperature (20—22). 

Most of the HCl produced is consumed captively, ie, at the site of production, either in integrated operations such as ethylenedichloride—vinyl chloride monomer (EDC/VCM) plants and chlorinated methane plants or in separate HCl consuming operations at the same location. Captive use of anhydrous HCl accounted for 80—85% of the total demand in 1989. The combined merchant market for anhydrous and aqueous HCl in that same year was about 9.1 X 10 metric tons on the basis of 100% HCl (see Table 12) (73). 

Minerals and Metals. HCl is consumed in many mining operations for ore treatment, extraction, separation, purification, and water treatment (see Mineral recovery and processing). Significant quantities are also used in the recovery ofmolybdenum (see Molybdenum and molybdenum alloys) and gold (see Gold and gold compounds). This market consumed about 36 thousand metric tons in 1993. 

This process is one of the three commercially practiced processes for the production of acetic anhydride. The other two are the oxidation of acetaldehyde [75-07-0] and the carbonylation of methyl acetate [79-20-9] in the presence of a rhodium catalyst (coal gasification technology, Halcon process) (77). The latter process was put into operation by Tennessee Eastman in 1983. In the United States the total acetic anhydride production has been reported to be in the order of 1000 metric tons. 

Whereas new appHcations of lithium compounds were developed, commercial growth was slow. In 1953 worldwide sales of lithium products, expressed as lithium carbonate, were only ca 1000 metric tons (2). In 1954 the U.S. lithium industry underwent a sudden, very large expansion when the U.S. Atomic Energy Commission required large amounts of lithium hydroxide [1310-65-2] for its nuclear weapons program (see Nuclearreactors). Three domestic producers built 4500-t/yr plants to meet contract commitments with the U.S. government. When these government contracts ended in 1960, capacity exceeded demand and several operations were discontinued. 

Estimated world production capacity for elemental phosphoms is shown in Table 5 (6). Three elemental phosphoms production sites remain operational in North America (14), although Rhc ne Poulenc has announced its intention to cease production in late 1995. The remaining plants have survived owing to the availabiUty of economical electric power in the Northwest and proximity to phosphate ore deposits, resulting in lower cost phosphoms. The capacity of these producers in 1995 was estimated to be 264,000 metric tons. U.S. production capacity peaked at approximately 622,000 metric tons in 1970. 

Nuclear Waste. NRC defines high level radioactive waste to include (/) irradiated (spent) reactor fuel (2) Hquid waste resulting from the operation of the first cycle solvent extraction system, and the concentrated wastes from subsequent extraction cycles, in a faciHty for reprocessing irradiated reactor fuel and (3) soHds into which such Hquid wastes have been converted. Approximately 23,000 metric tons of spent nuclear fuel has been stored at commercial nuclear reactors as of 1991. This amount is expected to double by the year 2001. 

A popular metric of the speed performance of a EET is, the maximum frequency of unity current gain (49). Eor short gate length devices operating at the saturated velocity this metric can be expressed as follows, where... 

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