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Of patient compliance

Second-Generation Antidepressants. The frequency of adverse effects associated with first-generation antidepressants and the lack of patient compliance arising from such adverse effects led to the development of a number of second-generation antidepressants. [Pg.231]

Treatment is based on several factors including likelihood of patient compliance, whether it is the first or a recurrent episode, host immunity, and pregnancy. However, patient response has been linked to the time it takes to initiate treatment after symptom onset. [Pg.1170]

An examination of the published literature does not suggest that this problem is extensive, although there are some reports [20] of high intrasubject variability. There is no reason to doubt that statisticians are well able to develop tests that could be used to quantify intrasubject variability [9,20-24]. However, the question as to how serious or widespread this problem may be in clinical practice is still in need of reliable data. In clinical use it is possible that for many, if not all drugs, intrapatient variability may well be more a function of patient compliances, variations in diet, use of other... [Pg.755]

Musshoff et al. [35] developed a method for the enantiomeric separation of the synthetic opioid agonist tramadol and its desmethyl metabolite using a Chiralpak AD column containing amylose tris-(3,5-dimethylphenylcarbamate) as chiral selector and a n-hexane/ethanol, 97 3 v/v (5mM TEA) mobile phase nnder isocratic conditions (1 mL/min). After atmospheric pressure chemical ionization (APCI), detection was carried out in positive-ion MS-MS SRM mode. The method allowed the confirmation of diagnosis of overdose or intoxication as well as monitoring of patients compliance. [Pg.666]

Therapy is perfectly adequate with simple iron salts (Table 2). In adults ferrous gluconate, fumarate or sulphate are all of proven equal efficiency. Approximately 50 mg of iron is present in each tablet with the remaining 300 mg made up with an inert filler. These are given on an empty stomach at least twice a day but should nausea prevail they can be taken with food. Absorption of slow release preparations is not recommended since iron is detached from the carrier beyond the main areas of absorption in the duodenum or jejunum. Stools turn black in all cases and this is a useful index of patient compliance. In 25% of individuals gastrointestinal tract side effects are encountered in the form of diarrhoea or constipation and patients will often spontaneously discontinue medication. It is therefore essential that a tablet-count be carried out on a regular basis with a substitute being provided when this first-line medication is intolerable. In children the same preparations are favoured as syrups these are given twice... [Pg.731]

Development of a prolonged action dosage form of ketoprofen will bring about several desirable therapeutic advantages improvement of patient compliance minimization of blood level fluctuations reduction of the total amount of drug administered reduction of incidence of both local and systemic adverse side effects [3]. [Pg.71]

Let us consider each issue in turn the definition and measurement of patient compliance, and the value of information about patient compliance and its correlates in a changing health care environment. [Pg.242]

Advances in measurement have freed the estimation of patient compliance from its long-standing dependence on methods easily manipulated by patients, whose reluctance to acknowledge poor compliance contributes to self-reporting bias, documented in many ways. The years 1986-1987 saw the introduction of chemical marker and electronic monitoring methods, which provide different but complementary estimates of the time history of dosing by ambulatory patients. These advances have been extensively reviewed (Feinstein, 1990 Pullar and Feely, 1990 Urquhart, 1990 Cramer and Spilker, 1991 Bond and Hussar, 1991 Vander Stichele, 1991 Kruse, 1992). The gist of both methods is as follows. [Pg.245]

Cohn JR, Pizzi A Determinants of patient compliance with allergen immunotherapy. J Allergy Clin Immunol 1993 91 734-737. [Pg.118]

Physical therapists and occupational therapists may help reinforce the importance of patient compliance during pharmacologic management of diabetes mellitus. Therapists can question whether patients have been taking their medications on a routine basis. Regular administration of insulin is essential in preventing a metabolic shift toward ketone body production and subsequent ketoacidosis, especially in patients with type 1 diabetes. In addition, therapists can help explain that adequate control of blood glucose not only prevents acute metabolic problems but also seems to decrease the incidence of the neurovascular complications. [Pg.491]

Ideally, biomarkers should be measurable in a versatile and easily accessible body fluid, such as serum or urine, to maximize clinical use in terms of patient compliance and readiness to interface with the diagnostic... [Pg.169]

Another contribution of gene cloning is the expression in transfected CHO cells of the N-terminal and C-terminal part of ACE (206). It has also allowed a more in-depth characterization of ACE inhibitors at its two active sites in the presence of different substrates, including N-acetyl (SDKP), whose hemoregulatory properties and physiological role are now being defined and which may become a target for future therapeutic research (207-210). In the meantime, the measurement of N-acetyl SDKP in plasma and urines may be a tool for the follow-up evaluation of patients compliance with ACE inhibitors (211). [Pg.41]

Future generations of HIV-1 protease inhibitors will focus primarily on two challenges. Improved pharmacokinetics are needed in new agents in order to reduce the complexity of current dosing regimens. Lack of patient compliance resulting from the complexity and life-style... [Pg.234]

Of the numerous factors that influence ocular drug efficacy and safety, one of the most important remains that of patient compliance. Determining the proper dosage regimen and getting patients to administer the medication is a primary responsibility of the practitioner. These factors are considered in Chapters 1 and 4. [Pg.36]

Of the many causes of failure of patient compliance the following case must be unique ... [Pg.19]

Evaluation of patient compliance. Merely asking patients whether they have taken the drug as directed is not likely to provide reliable evidence and it can be assumed that anything that can happen to impair compliance, will happen sometimes. Estimations of compliance are based on studies using a variety of measures. [Pg.21]

Another facet, obviously, is to deal with the patient whose compliance has been substandard and take effective action to make as much improvement as possible in drug intake, and to switch, if necessary, to the agent whose therapeutic actions are least influenced by lapses in dosing. These are, of course, new issues that have previously not been considered in drug evaluation, for the simple reason that reliable measures of patient compliance have not previously been available. The potential roles of pharmacists, nurses and other health professionals remain to be defined as this new information and its implications become available and integrated into clinical thinking. [Pg.366]

Eastell R, Garnero P, Vrijens B, van de Langerijt L, Pols HAP, Ringe JD, et al. 2003. Influence of patient compliance with risedronate therapy on bone turnover marker and bone mineral density response the impact study . In European Calcified Tissues Society Meeting, Rome, 8-12 May. [Pg.372]

Greenberg, R.N. Overview of patient compliance with medication dosing A literature review. Glin. Thcr. 1993, 6, 590-599. [Pg.22]


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See also in sourсe #XX -- [ Pg.1082 ]




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