Immunotherapy, allergen

Muller UR, Golden DBK, Lockey RF, Shin B Immunotherapy for Hymenoptera venom hypersensitivity in Lockey RF, Ledford DK (eds) Allergens and Allergen Immunotherapy. New York, Informa Healthcare, 2008, pp 377-392. 

In allergen immunotherapy, specific allergen extracts (also called allergen vaccines) are administered in order to modify or eliminate allergic rhinitis symptoms. 

Patients who may benefit from allergen immunotherapy include those who do not tolerate traditional drug therapy (e.g., nosebleeds with intranasal steroids or sedation with antihistamines), suffer from severe symptoms, have comorbid conditions (e.g., asthma or sinusitis), fail drug therapy, or prefer not to take long-term medication. 

American Academy of Pediatrics allergen immunotherapy allergic rhinitis central nervous system histamine-1 receptor antagonist immunoglobulin E over the counter perennial allergic rhinitis seasonal allergic rhinitis... 

Patient Education and Environmental Control at Each Step Steps 2-4 Consider SQ allergen immunotherapy for allergic patients... 

Muller U, Hari Y, Berchtold E Premedication with antihistamines may enhance efficacy of specific-allergen immunotherapy. J Allergy Clin Immunol 2001 107 81-86. 

Bousquet J, Lockey R, Mailing HJ, Alvarez-Cuesta E, Canonica GW, Chapman MD, et al Allergen immunotherapy therapeutic vaccines for allergic diseases. World Health Organization. American Academy of Allergy, Asthma and Immunology. 

Rolland JM, Douglass J, O Hehir RE Allergen immunotherapy current and new therapeutic strategies. Expert Opin Investig Drugs 2000 9 515-527. 

Otsuka H, Mezawa A, Ohnishi M, Okubo K, Seld H, Okuda M Changes in nasal metachromatic cells during allergen immunotherapy. Clin Exp Allergy 1991 21 115-119. 

Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT Allergen immunotherapy decreases interleukin-4 production in CD4+ T cells from allergic individuals. J Exp Med 1993 178 2123-2130. 

Frick OL, Teuber SS, Buchanan BB, Morigasaki S, Umetsu DT Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy 2005 60 243-250. Stock P, Akbari 0, DeKruyff RH, Umetsu DT Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol 2005 175 7380-7387. 

Clinical tolerance to allergens may be achieved by the administration of allergen extracts, which is called specific immunotherapy. In addition to its therapeutic value, it has been suggested that this treatment may also alter the progression of disease. Specific allergen immunotherapy (SIT) is used to alleviate the condition associated... 

Passalacqua G. 2007. Allergic rhinitis and its impact on asthma update. Allergen immunotherapy. 

Bousquet J, Lockey RE, Mailing HJ WHO Position Paper. Allergen immunotherapy Therapeutic vaccines for allergic diseases. Allergy 1998 53(suppl) 44. 

An allergen preparation has been administered via direct ingestion (oral route) or by so-called mucosal routes nasal, sublingual or oromucosal. This implies that some local effects or local absorption were expected. As a matter of fact, a demonstration of the clinical efficacy of mucosal allergen immunotherapy has been provided, and some hypotheses about its mechanism of action have been formulated [15-19,24-32],... 

All these experimental data, in addition to contributing to a better understanding of the mechanisms of action of local allergen immunotherapy, may make it possible to better devise treatment protocols and allergen/allergoid preparations for therapeutic use. 

Abramson MJ, Puy RM, Weiner JM Is allergen immunotherapy effective in asthma A metaanalysis of randomized controlled trials. Am J Respir Crit Care Med 1995 151 969-974. 

Greenberg MA, Kaufman CR, Gonzales GE, Rosenblatt CD, Smith LJ, Summers RJ Late and immediate systemic-allergic reactions to inhalant allergen immunotherapy. J Allergy Clin Immunol 1986 77 865-870. 

Nuttall TJ, Thoday KL, van den Broek AH, et al Retrospective survey of allergen immunotherapy in canine atopy. Vet Rec 1998 143 139-142. 

Lockey RF, Nicoara-Kasti GL, Theodoropoulos DS, Bukantz SC Systemic reactions and fatalities associated with allergen immunotherapy. Ann Allergy Asthma Immunol 2001 87(suppl 1) 47-55. 

Lower T, Hensy J, Mandik L, et al Compliance with allergen immunotherapy. Ann Allergy 1993 ... 

Rolland, J. M. and O Hehir, R. E. 2001. Targeting the allergen-specific CD4+ T cell-strategies for improved allergen immunotherapy. Allergy Clin Immunol Int J World Allergy Org 13 170-177. 

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