OECD Advisory

Study Director. The same holds also for the task of ensuring that test facility supplies meet specifications and requirements appropriate to their use in a study. This division of responsibilities , or rather the joint observance of responsibilities, has been pragmatically fixed in the OECD Advisory Document on in vitro Studies (OECD No. 14, 2004) where it is stated that, although management is ultimately responsible for ensuring the quality of supplies, it is the Study Director who is best able to judge the adherence of specialised supplies (e.g. test kits, etc.) to specifications and performance characteristics. 

A special case has been addressed in the OECD Advisory Document on in vitro studies (OECD No. 14, 2004). In this area of rapid progress, especially with the development of genetically engineered test systems, there may be instances where test systems are of limited availability, or have even been... 

Eggenberger and Waber 1998, Cadmium in Seepage Waters of Landfills A Statistical and Geochemical Evaluation, Report of November 20, 1997 for the OECD Advisory Group on Risk Management Meeting, February 9-10,1998, Paris, France. 

The eChemPortal is an effort of the Organisation for Economic Co-operation and Development (OECD) in collaboration with the European Commission, the United States, Canada, lapan, the International Council of Chemical Associations, the Business and Industry Advisory Committee, the World Health Organization s International Program on Chemical Safety, the United Nations Environment Programme on Chemicals and environmental non-governmental organizations. 

This activity was launched at the request of the Member countries and the Business and Industry Advisory Commitee (BIAC) to the OECD to ensure that testing and assessment approaches for endocrine dismpters would not substantially differ among countries. An overview of the extent and... 

Once the test method has been validated, the ECVAM Scientific Advisory Committee (ESAC) produces a statement or recommendation on the use of the test method. In some cases, regulatory acceptance is achieved via adoption of the test method by a relevant European commission (e.g., a new Commission Regulation) or a new OECD Test Guideline (Organisation for Economic Co-operation and Development (OECD)). 

OECD (1998b) Report of the Second Meeting of the Joint National Coordinators Meeting/Risk Assessment Advisory Board (NCM/RAAB) Working Group on Endocrine Disrupter Testing and Assessment (EDTA Task Force), 12-13 November 1998. Paris, Organisation for Economic Cooperation and Development. 

Development Advisory Committee. DAC members of OECD evolve guidelines for environment and development in bilateral aid policies, http //www.oecd.org/home/... 

OECD (2004) OECD series on principles of good laboratory practice and compliance monitoring. Number 14. Advisory document of the working group on good laboratory practice the application of the principles of GLP to in vitro studies. ENV/JM/MONO(2004)26... 

In the course of the development of further guidance by the OECD Working Group on GLP to the interpretation of the GLP Principles in the form of the various Consensus and Advisory Documents, it became necessary to define additional terms, that were considered too specialised to introduce... 

It was therefore obvious that the sponsor should become more involved in the issues of GLP compliance, although as the entity which commissions, supports and/or submits a non-clinical health and environmental safety study the sponsor itself may not be directly involved in the conduct of a study under GLP. Thus, it is questionable whether the GLP Principles could have imposed any responsibilities directly to a sponsor with only a commissioning and (financially) supporting role in the conduct of a study, although several explicit references to the sponsor have been introduced into the revised GLP Principles. In order to deal with these problems and questions, certain aspects on the role and responsibilities of the sponsor have been discussed and compiled in an Advisory Document (OECD No. 11,1998). 

In a way, the sponsor may be regarded as some kind of a bracket around the study At the start there is the commissioning of the study by the sponsor, and at the end, there is the submission of the study by the sponsor to the Regulatory Authority. GLP is not involved in either of the two points. If the sponsor is not directly involved in the experimental study conduct, this entity may therefore be seen as independent from, and unconnected to, any responsibility in the field of GLP. On the other hand, the sponsor may greatly help or hinder the GLP-compliant conduct of the studies commissioned by him, and it should be in his well imder-stood self-interest to do the former rather than the latter. The GLP Principles, and the respective Advisory Document of the OECD, do address certain aspects in the relationship of the sponsor with the test facility, in order that sponsors should fully understand and correctly interpret their role in the area of GLP compliance. 

Industry has agreed to assist the OECD by supplying existing data, as well as by undertaking any necessary additional testing in a timely manner. Chemical review meetings are attended by observers from the OECD Business and Industry Advisory Committee (BIAC), and by chemical manufacturers. 

In EEC terminology an environmental queJity objective expresses the maximum pollution levels to be satisfied in the environment in order to safeguard an effective protection of the ecosystem by taking into accoimt the so -called zero-effect evaluation (EEC, 1973). The term is comparable with the water quality criteria applied by the US Environmental Protection Agency (USEPA, 1987) and by the European Inland Fisheries Advisory Committee (Uoyd and Ctilamari, 1987), and also with the concepts of environmental concern level of the Organisation for Economic Co-operation and Development (OECD, 1992) and maximum permissible concentration... 

Notification of nuclear accidents, whether from NPS or other nuclear installations, especially those resulting in the release of radioactivity to the environment, should be immediately notified not only to the national regulatory authorities, but also to the international advisory authorities such as the IAEA, NEA, OECD, etc. This will enable those countries likely to be affected by the activity released to take appropriate countermeasures so as to reduce the consequences of such an event. 

RADIOACTIVE WASTE MANAGEMENT ADVISORY COMMITTEE (RWMAC), Report from the RWMAC on British Nuclear Fuels pic Proposals for the Return of Waste Resulting from the Reprocessing of Nuclear Spent Fuel to Overseas Utilities, 14th Annual Report of the RWMAC, London (June 1994), 54 - 57 THE RADIATION PROTECTION AND NUCLEAR SAFETY AUTHORITIES IN DENMARK, HNLAND, ICELAND, NORWAY AND SWEDEN, "Disposal of High-Level Radioactive Waste - Consideration of Some Basic Criteria", Stockholm (1992) "Technical Appraisal of the Current Situation in the Field of Radioactive Waste Management", a Collective Opinion of the NEA Radioactive Waste Management Committee, OECD, Paris (1985)... 

In 1990 the OECD/NEA established a Working Group on the Assessment of Future Human Actions at Radioactive Waste Disposal Sites. This group published its final report in 1995 [11]. The following review is heavily based on this report. Additionally, use has been made of discussions within the Sub-Group on Principles and Criteria for Radioactive Waste Disposal of the International Radioactive Waste Management Advisory Group (INWAC) of the IAEA. 

U.S. DOE Nuclear Energy Research Advisory Committee and the Generation IV International Forum, 2002. A Technology Roadmap for Generation IV Nuclear Energy Systems. GIF-002-00. OECD Nuclear Energy Agency, Paris. 

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