Nitric oxide inhibition

Clancy, R.M., Leszczynska-Piziak, J. and Abramason, S.B. (1992). Nitric oxide inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J. Clin. Invest. 90, 1116-1121. 

Hogaboam, C.M., Jacobson, K., Collins, S.M. and Blennerhassett, M.G. (1995) The selective beneficial effects of nitric oxide inhibition in experimental colitis. American Journal of Physiology 268, G673—684. 

Abas F, Lajis NH, Israf DA, Khozirah S and Kalsom YU. 2006. Antioxidant and nitric oxide inhibition activities of selected Malay traditional vegetables. Food Chem 95(4) 566-573. 

Chamulitrat, W., 1998, Nitric oxide inhibited peroxyl and aUcoxyl radical formation with concomitant protection against oxidant injury in intestinal epithehal cells, A r/t. Biochem. Biophys. 355 206-214. 

KeUey, E. E., Wagner, B. A., Buettner, G. R., and Bums, C. P., 1999, Nitric oxide inhibits iron-induced Upid peroxidation in HL-60 cells. Arch. Biochem. Biophys. 370 97-104. 

O DormeU, V. B., Chumley, P. H., Hogg, N., Bloodsworth, A., Darley-Usmar, V. M., and Freeman, B. A., 1997, Nitric oxide inhibition of Upid peroxidation kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol, Biochemistry 36 15216-15223. 

Ruhho, H., Parthasarathy, S., Barnes, S., Kirk, M., Kalyanaraman, B., and Freeman, B. A., 1995, Nitric oxide inhibition of hpoxygenase-dependent hposome and low-density hpoprotein oxidation termination of radical chain propagation reactions and formation of nitrogen-containing oxidized hpid derivatives, Arclr. Biochem. Biophys. 324 15-25. 

A fourth modification of the classical model involves nitric oxide (NO), a new form of nonsynaptic interneuronal communication, or volume transmission. Nitric Oxide inhibits the uptake of dopamine, norepinephrine (Lonart and Johnson, 1994), and serotonin (Asano et ah, 1997) into neurons and is closely linked to glutamate-mediated neurotransmission. Nitric Oxide synthase is switched on only by glutamatergic receptors and appears to enhance the strength of glutamatergic input to monoaminergic neurons without requiring direct synaptic contact (Kiss and Vizi, 2001). 

Treatment of isolated hepatocytes with authentic nitric oxide inhibits the electron transport chain at complexes I and II, and mitochondrial aconitase activity (Stadler et al., 1991). 

Nitric oxide inhibition has an analgesic effect in patients with chronic tension-type headache, probably due to a reduction in central sensitization at the level of the spinal dorsal horn, trigeminal nucleus or both (Ashina, 2002). 

Ohkita M, Takaoka M, Shiota Y, Nojiri R, Matsumura Y. 2002. Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor kappa B. Clin Sci 103 68S-71S. 

Japanese scientists believe that the anti-oketsu effects of rhubarb are brought about by the inhibition of the production of nitric oxide, inhibition of platelet aggregation, antiallergic effects, and its antiinflammatory properties. Matsuda et al. (2001) studied and reported that the methanolic extracts from five kinds of rhubarb were found to show scavenging activity for l,l-diphenyl-2-picrylhy-drazyl (DPPH) radical and superoxide anion radical (02 ) generated by the xanthine/xanthine oxidase system and/or on lipid peroxidation by terf-butyl hydroperoxide (f-BuOOH) in the erythrocyte membrane ghost system. 

Nitric oxide also appears to play an important protective role in the body via immune cell function. When challenged with foreign antigens, THl cells (see Chapter 56 Immunopharmacology) respond by synthesizing nitric oxide. Inhibition of NOS and knockout of the NOS-2 gene can markedly impair the protective response to injected parasites in animal models. 

Dubey, R. K., Jackson, E. K., and Luscher, T. F. 1995. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin 1 receptors. J Clin Invest 96 141-149. 

Wang, D., Yu, X., and Brecher, P. 1999. Nitric oxide inhibits angiotensin II-induced activation of the calcium-sensitive tyrosine kinase proline-rich tyrosine kinase 2 without affecting epidermal growth factor receptor transactivation. J. Biol. Chem. 274 24342-24348. 

Reduction of nitric oxide by carbon monoxide was first reported to occur at low temperature (252-369 K) over gold powder (0.86 m2 g-1) 30 the rate was maximal at 314 K, and nitric oxide inhibited the reaction. This paper also provides an early indication of the activity of gold for the oxidation of carbon monoxide near ambient temperature. Nitric oxide reduction occurs in this way in catalytic converters for the treatment of engine exhaust gases 9... 

Edwards, S. L., Kraut, J., and Poulos, T. L., 1988, Crystal structure of nitric oxide inhibited cytochrome c peroxidase. Biochemistry 27 8074n8081. 

Brown, C.G., Cooper, C.E. (1994). Nanomolar concentrations of nitric oxide inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356 295-8. 

Radomski, M.W., Palmer, R.M., and Moncada, S., Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet, 2, 1057, 1987. 

AM, Mulsch A, Dimmeler S. Nitric oxide inhibits caspase-3 by 51. S-nitrosation in vivo. J. Biol. Chem. 1999 274 6823-6826. 

KomamuraK,NodeK, KosdcaH, InoueM(1994) Endogenous nitric oxide inhibits microthranboembolism in the ischemic heart. Circulation 90 1-345. 

Radcandd MW, Palmer RMJ, Moncada S (1987a) Endogenous nitric oxide inhibits human platdet adhesion to vascular endothdium. Lancet 2 1057-1058. 

The main products of the gas-phase photolysis at 300 °K, with nitric oxide added, are hydrogen, propene, ethylene and pentenes. Other important products are ethane, butenes, methane, propane, butane and acetylene. A reaction scheme that accounts for most of the products of the nitric oxide-inhibited photolysis is as follows... 

Nitric oxide inhibits the formation of hydrocarbons in the photolysis of acetaldehyde. The results of the investigations -carried out in the presence of iodine as an inhibitor, furnish further convincing evidence in favour of the participation of free radicals. 

Nitric oxide inhibits the photolysis of acetaldehyde, and decreases the ratio CH4/CO from unity to a very small value. The formation of ethane is also inhibited. It may be assumed that the ratio 0n/0i can be obtained by measuring the ratio CH4/(C0-CH4) at high temperatures in the presence of NO. The values, determined in this manner at 300°C, are 0.08 and 0.21 at 3130 Aand 2537 A, respectively. At 2537 A, the agreement with the iodine-inhibition experiments is poor. 

P. Klatt, E. Pineda Molina, and S. Lamas, Nitric oxide inhibits c-Jun DNA binding by specifically targeted S-glutathionylation, J. Biol. Chem. 274(1999) 15857-15864. 

The authors suggested that in this case the effect of sildenafil may have been reduced by impaired gastrointestinal absorption. They speculated that exogenous nitric oxide inhibits nitric oxide sjmthase activity, with a consequent reduction in pulmonary vascular smooth muscle cGMP concentration. Phosphodiesterase type V inhibitors, such as sildenafil, increase cGMP concentration and ameliorate the rebound effect... 

Plato CF, Stoos BA, Wang D, et al. Endogenous nitric oxide inhibits chloride transport in the thick ascending limb. Am J Physiol. 

Gardner MP, Houghton DC, AndohTF, Lindsley J, Bennett WM. Clinically relevant doses and blood levels produce experimental cyclosporine nephrotoxicity when combined with nitric oxide inhibition. Transplantation 1996 61 1506-1512. 

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