Chloride , transport

C1C-6 is a late endosomal chloride transporter. Its disruption in mice led to lysosomal storage disease. C1C-7 is expressed in late endosomes and lysosomes. It needs Ostml as (3-subunit [3]. The disruption of either C1C-7 or Ostml in mice and man leads to severe osteopetrosis, retinal degeneration, and a severe lysosomal storage disease. ClC-7/Ostml is highly expressed in osteoclasts. In these cells, it is inserted together with the proton pump into the specialized plasma membrane ( ruffled border ) that faces the reabsorption lacuna. Osteoclasts are still present in C1C-7 knockout... 

Jentsch, TJ (2007) Chloride and the endosomal lysosomal pathway — emerging roles of CLC chloride transporters. J Physiol 578. 3 663-640... 

Gant DB, Eldefrawi ME, Eldefrawi AT. 1987. Cyclodiene insecticides inhibit GABA receptor-regulated chloride transport. Toxicol Appl Pharmacol 88 313-321. 

SD Klyce, RKS Wong. (1977). Site and mode of adrenaline action on chloride transport across the rabbit corneal epithelium. J Physiol 266 777-799. 

M Chalfie, AH Neufeld, JA Zadunaisky. (1972). Action of epinephrine and other cyclic AMP-mediated agents on the chloride transport of the frog cornea. Invest Ophthalmol 11 644-650. 

SD Klyce, AH Neufeld, JA Zadunaisky. (1973). The activation of chloride transport by epinephrine and Db cyclic-AMP in the cornea of the rabbit. Ophthalmol 12 127-138. 

OA Candia, R Montoreano, SM Podos. (1977). Effect of the ionophore A23187 on chloride transport across isolated frog cornea. Am J Physiol 233 F94-F101. 

OA Candia. (1973). Effect of pH on chloride transport across the isolated bullfrog cornea. Exp Eye Res 15 375-382. 

SD Klyce, KA Palkama, M Harkonen, WS Marshall, S Huhtaniitty, KP Mann, AH Neufeld. (1982). Neural serotonin stimulates chloride transport in the rabbit corneal epithelium. Invest Ophthalmol Vis Sci 23 181-192. 

O Eriksson, PJ Wistrand. (1986). Inhibitory effects of chemically-different loop diuretics on chloride transport across the bullfrog cornea. Acta Physiol Scand 127 137-144. 

XP Shi, OA Candia. (1995). Active sodium and chloride transport across the isolated rabbit conjunctiva. Curr Eye Res 14 927-935. 

KW Gasser, J DiDomineco, UH Hopfer. (1988). Secretagogues activate chloride transport pathways in pancreatic zymogen granules. Am J Physiol 254 G93-G99. 

BE Schaeffer, JA Zadunaisky. (1979). Stimulation of chloride transport by fatty acids in corneal epithelium and relation to changes in membrane fluidity. Biochim Biophys Acta 556 131-143. 

BR Beitch, I Beitch, JA Zadunaisky. (1975). The stimulation of chloride transport by prostaglandins and their interaction with epinephrine, theophylline and cyclic AMP in the comeal epithelium. J Membr Biol 19 381-396. 

JA Zadunaisky, MA Lande, J Hafner. (1971). Further studies on chloride transport in the frog cornea. Am J Physiol 221 1832-1836. 

Transport proteins (channels) for chloride and zinc Vacuolar proton pump Components of synaptic vesicles to mediate the chloride flux for glutamate uptake and zinc uptake in most synaptic vesicles. Zinc transporter is homologous to endosomal and plasma membrane zinc transporters chloride transporters remain to be identified. Protein complex of more than 12 subunits. Constitutes the largest component of synaptic vesicles and establishes... 

A. C. Chao, J. A. Dix, M. C. Sellers, and A. S. Verkman, Fluorescence measurement of chloride transport in monolayer cultured cells. Mechanisms of chloride transport in fibroblasts, Biophys. J. 56, 1071-1081 (1989). 

Answer B. The pathogenesjs of CF is related to defective chloride transport in epithelial... 

INTESTINE Characterization of a membrane potassium ion conductance in intestinal secretory cells using whole cell patch-clamp and calcium-sensitive dye techniques, 192, 309 isolation of intestinal epithelial cells and evaluation of transport functions, 192, 324 isolation of enterocyte membranes, 192, 341 established intestinal cell lines as model systems for electrolyte transport studies, 192, 354 sodium chloride transport pathways in intestinal membrane vesicles, 192, 389 advantages and limitations of vesicles for the characterization and the kinetic analysis of transport systems, 192, 409 isolation and reconstitution of the sodium-de-pendent glucose transporter, 192, 438 calcium transport by intestinal epithelial cell basolateral membrane, 192, 448 electrical measurements in large intestine (including cecum, colon, rectum), 192, 459... 

Failure of a critical chloride transport protein to fold properly into its functional conformation contributes to many cases of cystic fibrosis (CF), which is the most common fatal inherited disorder of white people. 

Cystic fibrosis (CF)—genetic disease affecting the lungs and pancreas caused by a mutation of a gene for chloride transport protein. It was targeted by early efforts at gene therapy, but without success. 

Boisen AM et al (2003) Sodium and chloride transport in soft water and hard water acclimated zebrafish (Danio rerio). Biochim Biophys Acta 1618 207-218... 

Zhao, Z., Li, X., Hao, J., Winston, J. H., and Weinman, S. A. (2007) The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin J Biol Chem 282,29022-29031. 

Susdak PD, Schwartz RD, Scolnick P, et al Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci U S A 83 4071-4075, 1986... 

Ion transport pathways across the luminal and basolateral membranes of the distal convoluted tubule cell. As in all tubular cells, Na+/K+ ATPase is present in the basolateral membrane. NCC is the primary sodium and chloride transporter in the luminal membrane. (R, parathyroid hormone [PTH] receptor.)... 

Tire uncoupling protein resembles the ATP/ADP and phosphate anion carriers (Table 18-8), 1 which all have similar sizes and function as homodimers. Each monomeric subunit has a triply repeated 100-residue sequence, each repeat forming two transmembrane helices. Most mitochondrial transporters carry anions, and UCP1 will transport Cl. h/1 However, the relationship of chloride transport to its real function is unclear. Does the protein transport H+... 

---