Nephrotoxicity cyclosporine

Absorption of tacrolimus from the gastrointestinal (GI) tract is variable. It is extensively metabolized in the liver and excreted in the urine. As with cyclosporine, nephrotoxicity is its principal side effect. [Pg.660]

Grinyo JM, Cruzado JM. Cyclosporine nephrotoxicity. Transplant Proc. 2004 36(suppl) 240S-242S. [Pg.603]

N. A. Bobadilla, G. Gamba, E. Tapia, R. Garcia-Torres, A. Bolio, P. Lopez-Zetina, et al.. Role of No in Cyclosporin Nephrotoxicity Effects of Chronic No Inhibition and No Synthases Gene Expression, Am J Physiol 11A (1998) F791-8. [Pg.43]

C. Wang, A. K. Salahudeen, Lipid Peroxidation Accompanies Cyclosporine Nephrotoxicity Effects of Vitamin E, Kidney Int 47 (1995) 927-34. [Pg.44]

Jahansouz F, Kriett JM, Smith CM, Jamieson SW. Potentiation of cyclosporine nephrotoxicity by nafcillin in lung transplant recipients. Transplantation... [Pg.502]

Greenberg A, Thompson ME, Griffith BJ, Hardesty RL, Kormos RL, el-Shahawy MA, Janosky JE, Puschett JB. Cyclosporine nephrotoxicity in cardiac allograft patients— a seven-year follow-up. Transplantation 1990 50(4) 589-93. [Pg.764]

Ader JL, Rostaing L. Cyclosporin nephrotoxicity pathophysiology and comparison with FK-506. Curr Opin Nephrol Hypertens 1998 7(5) 539 5. [Pg.765]

Navakova I, Donnelly P, de Witte T, de Pauw B, Boezeman J, Veltman G. Itraconazole and cyclosporin nephrotoxicity. Lancet 1987 2(8564) 920-1. [Pg.1945]

Extensive expression of KlM-1 has been found in proximal tubule cells in biopsies from patients with acute tubular necrosis [302]. KlM-1 is also expressed in other conditions where proximal tubules are dedifferentiated, including renal cell carcinoma [303, 304], chronic cyclosporine nephrotoxicity [305], a protein-overload model of tubulointerstitial disease [306], polycystic kidney disease [307], and contrast nephropathy. In several chronic conditions, KlM-1 has been found primarily expressed at the luminal side of dedifferentiated proximal tubules, in areas with fibrosis and inflammation. Independent of the specific disease, renal KIM-1 correlated positively with the extent of renal damage and negatively with renal function. In these patients, urinary levels of KIM-1 were and correlated positively with tissue KIM-1 and negatively with renal function. Thus, KIM-1 is upregulated in renal disease and is associated with renal fibrosis and inflammation. Urinary KIM-1 is also associated with inflammation and renal function, and reflects tissue KIM-1. [Pg.114]

Camara NO, Matos AC, Rodrigues DA, Pereira AB, Pacheco-Silva A. Urinary retinol binding protein isa good marker of progressive cyclosporine nephrotoxicity after heart transplant. Transplant Proc 2001 33(3) 2129-2131. [Pg.121]

Tataranni G, Zavagli G, Farinelli R, Malacarne F, Fiocchi O, Nunzi L, Scaramuzzo P, Scorrano R. Usefulness of the assessment of urinary enzymes and microproteins in monitoring cyclosporine nephrotoxicity. Nephron 1992 60 314-318. [Pg.123]

Perez-Rojas J, Blanco JA, Cruz C, Trujillo J, Vaidya VS, Uribe N, Bonventre JV, Gamba G, Bobadilla NA Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 292 FI 31 -FI 39,... [Pg.128]

The effect of various mediators on the renal micro-circulation are summarized in Table 10. The effects of various drugs, including cyclosporine nephrotoxic-ify, on the renal microcirculation are summarized in Table 11. [Pg.189]

Yang CW, Faulkner GR, Wahba IM, Christianson TA, Bagby GC, Jin DC, Abboud HE, Andoh TF, and Bennett WM. Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in mice. Am JTransplant 2 391-399,2002. [Pg.243]

Johnson DW, Saunders HJ, Vesey DA, Qi W, Field MJ, and PollockCA. Enalaprilat directly ameliorates in vitro cyclosporin nephrotoxicity in human tubulo-interstitial cells. Nephron 86 473-481,2000. [Pg.243]

Paller MS, Paller MS. The prostaglandin El analog misoprostol reverses acute cyclosporine nephrotoxicity. Transplantation Proceedings 1988 20 634-637. [Pg.456]

Mihatsch MJ, Thiel G, Ryffel B. Histopathology of cyclosporine nephrotoxicity. Transplant Proc 1988 20 759-771. [Pg.651]

Verpooten GA, Wybo I, Pattyn VM, Hendrix PG, Giuliano RA, Nouwen EJ, Roels F, De Broe ME. Cyclosporine nephrotoxicity comparative cytochemical study of rat kidney and human allograft biopsies. Clin Nephrol 1986 25 SuppI 1 S18-S22. [Pg.651]

Barros EJ, Boim MA, Ajzen H, Ramos OF, Schor N. Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity. Kidney Int 1987 32 19-25. [Pg.652]

Kaskel FJ, Devarajan P, Arbeit LA, Partin JS, Moore LC. Cyclosporine nephrotoxicity sodium excretion, autoregulation, and angiotensin II. Am J Physiol 1987 252 F733-F742. [Pg.652]

Bobadilla NA, Gamba G,Tapia E, Garcia-Torres R, Bolio A, Lopez-Zetina P, Herrera-Acosta J. Role of NO in cyclosporin nephrotoxicity effects of chronic NO inhibition and NO synthases gene expression. Am J Physiol 1998 274 F791-F798. [Pg.654]

Assis SM, Monteiro JL, Seguro AC. L-Arginine and allopurinol protect against cyclosporine nephrotoxicity.Transplantation 1997 63 1070-1073. [Pg.654]

Bobadilla NA, Tapia E, Franco M, Lopez P, Mendoza S, Garcia-Torres R, Alvarado JA, Herrera-Acosta J. Role of nitric oxide in renal hemodynamic abnormalities of cyclosporin nephrotoxicity. Kidney Int 1994 46 773-779. [Pg.654]

AndohTF, Gardner MP, Bennett WM. Protective effects of dietary L-arginine supplementation on chronic cyclosporine nephrotoxicity.Transplantation 1997 64 1236-1240. [Pg.654]

ChanderV, Chopra K. Effect of molsidomine and L-arginine in cyclosporine nephrotoxicity role of nitric oxide. Toxicology 2005 207 463-474. [Pg.654]

Gardner MP, Houghton DC, AndohTF, Lindsley J, Bennett WM. Clinically relevant doses and blood levels produce experimental cyclosporine nephrotoxicity when combined with nitric oxide inhibition. Transplantation 1996 61 1506-1512. [Pg.654]

Coffman TM, Carr DR, Yarger WE, Klotman PE. Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity.Transplantation 1987 43 282-285. [Pg.655]

Parra T, de Arriba G, Conejo JR, Cantero M, Arribas i, Rodriguez-Puyol D, Rodriguez-Puyol M, Carballo F. Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats effect of vitamin Eon cyclosporine nephrotoxicity.Transplantation 1998 66 1325-1329. [Pg.655]

Butterly DW, Spurney RE, Ruiz P, Griffiths R, Albrightson C, Coffman TM. A role for leukotrienes in cyclosporine nephrotoxicity. Kidney int 2000 57 2586-2593. [Pg.656]

Wang C, Salahudeen AK. Cyclosporine nephrotoxicity attenuation by an antioxidant-inhibitor of lipid peroxidation in vitro and in v Vo.Transplantation 1994 58 940-946. [Pg.657]

Wang C, Salahudeen AK. Lipid peroxidation accompanies cyclosporine nephrotoxicity effects of vitamin E. Kidney Int 1995 47 927-934. [Pg.657]

Balakrishnan VS, von Ruhland CJ, Griffiths DF, Coles GA, Williams JD. Effects of a selective adenosine A1 receptor antagonist on the development of cyclosporin nephrotoxicity. Br J Pharmacol 1996 117 879-884. [Pg.659]

BagnIsC, Deray G, Dubois M, Pirotzky E, Jacquiaud C, Baghos W, Aupetit B, Braquet P, Jacobs C. Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist. Nephrol Dial Transplant 1996 11 507-513. [Pg.659]

Capasso G, Rosati C, Clan F, Giordano DR, Russo F, De Santo NG.The beneficial effect of atrial natriuretic peptide on cyclosporine nephrotoxicity. Am J Hypertens 1990 3 204-210. [Pg.659]

Lipkin GW, Thuraisingham R, Dawnay AB, Harwood SM, Raine AE. Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients.Transplantation 1997 64 1007-1017. [Pg.659]

Burdmann EA, Andoh TF, Lindsley J, Houghton DC, Bennett WM. Effects of oral magnesium supplementation on acute experimental cyclosporin nephrotoxicity. Nephrol Dial Transplant 1994,-9 16-21. [Pg.660]

Devarajan P, Kaskel FJ, Arbeit LA, Moore LC. Cyclosporine nephrotoxicity blood volume, sodium conservation, and renal hemodynamics. Am J Physiol 1989 256 F71-F78. [Pg.660]

Huang X, Cheng Z, Sunga J, Unemori E, Zsebo K. Systemic administration of recombinant human relaxin (RHRLX) ameliorates the acute cyclosporine nephrotoxicity in rats.J Heart Lung Transplant 2001 20 253-... [Pg.660]

Parry G, Meiser B, Rabago G.The clinical impact of cyclosporine nephrotoxicity in heart transplantation. Transplantation 2000 69 SS23-SS26. [Pg.661]

Greenberg A, Egel JW, Thompson ME, Hardesty RE, Griffith BP, Bahnson HT, Bernstein RL, Hastillo A, Hess ML, Puschett JB. Early and late forms of cyclosporine nephrotoxicity studies in cardiac transplant recipients. Am J Kidney Dis 1987 9 12-22. [Pg.662]

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