Antiallergic effect

In many countries, glucocorticosteroids are administered as first drug because of their well-known antiallergic effects. However, the onset of action of corticosteroids takes at... 

Fukuishi N, Takada T, Fukuyama Y, Akagi M. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. Phytomedicine 2001 8 460-464. 

For example, sol-gel immobilised bioactive liquids such as cineol, camphor, menthol, evening primrose and perilla oil used to functionalise textiles afford either skin-friendly textiles with antimicrobial and antiallergic effects due to immobilised natural oils or textiles for therapeutic treatment of the respiratory tract by means of immobilised mixtures of high volatility natural agents such as eucalyptol, camphor and menthol.27... 

Certain plants of the family Solanaceae, such as Atropa belladonna L., Hyoscyamus niger L., and Datura stramonium L., have been used medicinally for centuries in Europe because they contain tropane-type alkaloids.For example, atropine (1) [a racemic mixture of (+)- and (—)-hyoscyamine (2)] and (-)-hyoscyamine are competitive antagonists at the muscarinic acetylcholine receptor site, leading to antispasmodic and antiallergic effects. Scopolamine [(—)-hyoscine)] (3) is used in a transdermal patch for the prevention of motion sickness. Since these tropane alkaloids penetrate the blood-brain barrier, they also have psychoactive effects. ... 

Cromoglycate and nedocromil are known to stabilize the outer cell membrane of mast cells and thereby inhibiting the release of histamine and leukotrienes. Their antiallergic effect might be due to more than one mechanism, for example by additionally reducing the sensitivity of inflammatory cells towards histamine. 

Japanese scientists believe that the anti-oketsu effects of rhubarb are brought about by the inhibition of the production of nitric oxide, inhibition of platelet aggregation, antiallergic effects, and its antiinflammatory properties. Matsuda et al. (2001) studied and reported that the methanolic extracts from five kinds of rhubarb were found to show scavenging activity for l,l-diphenyl-2-picrylhy-drazyl (DPPH) radical and superoxide anion radical (02 ) generated by the xanthine/xanthine oxidase system and/or on lipid peroxidation by terf-butyl hydroperoxide (f-BuOOH) in the erythrocyte membrane ghost system. 

Vogelson CT, Abelson MB, PasquineT, et al. PrecUnical and clinical antiallergic effect of olopatadine 0.2% solution 24 hours after topical ocular administration. Allergy Asthma Proc 2004 69-75. 

Hexahydropyrimido[l,2-a]azepin-4-ones 456, 463, and 467 display analgetic activity (77MI1). 10-Aminomethylene and 10-phenylhydrazino derivatives 478 (R = H) possess weak antiallergic effects in the passive cutaneous anaphylaxis (PCA) test (84JMC1253). 

Mentha piperita subsp. citrata Briq. -horteia Tranquilizer Branch (infusion, ingested) Caboclos [57] Essential oils [138,139] flavonoid glycosides [140,141] menthol [142] menthofurolactone [143,144] pyridine-derivatives [145] mintlactone [146] flavones [147] triterpenes [148] terpenoids [149] sesquiterpenic hydrocarbons [150] menthofuran [151,152], Antimicrobial and antioxidant activities [138,265] antiallergic effect [140] anti-nociceptive and anti-inflammatory effects [266]... 

Aromoline and ten other bisbenzylisoquinoline alkaloids were evaluated in the in vitro histamine release inhibition assay. This assay is one of the basic tests that is used in the evaluation of substances for antiallergic effects. The order of potency of inhibitory effect of those bisbenzylisoquinoline alkaloids that have been isolated from Thalictrum species was as follows homoaromoline > aromoline > isotetrandrine > obaberine > tetrandrine. Berbamine and oxyacanthine were found to have no inhibitory effect [178]. 

The anti-inflammatory and antiallergic effects of aromoline were evaluated via the measurement of antigen-induced histamine release from leukocytes, and it was found that the alkaloid inhibited antigen-induced histamine release [180]. 

Johansson suggested that heparin has an antiallergic effect in many. Dahl tried this suggestion experimentally, and he was able to prevent experimentally induced allergic asthma by injecting his patients with heparin just before exposing them to the specific antigen. Videbak showed heparin effective in a few patients with autoimmune hemolytic anemia. 

Simons FE The antiallergic effects of antihistamines (Hl-receptor antagonists). J Allergy Clin Immunol... 

A pyrimido[ 1,2-c]quinazoline-4-carboxylic acid derivative (FR50948) exhibits excellent antiallergic effects <88MI 825-01 >. 

Adrenal insufficiency, previously treated with extracts of adrenal cortex, is now treated by the administration of pure A.C. High doses reveal other pharmacological properties, especially anti-inflammatory and antiallergic effects. This discovery led to the development of highly active synthetic derivatives, which are now us to treat rheumatism, asthma, allergies, eczema, etc., e.g. prednisone (see Prednisolone), Dexamethasone (see) and Ttiamdnolone (see). 

Modulation of the activities of immune system, antiallergic effect... 

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