Nitric oxide endogenous

The dorsal horn of the spinal cord contains many transmitters and receptors. Some of these include peptides, eg. substance P, somatostatin and neuropeptide Y excitatory amino acids, e.g. glutamate and aspartate inhibitory amino acids, e.g. y-aminobutyric acid (GABA) nitric oxide endogenous opioids adenosine and the monoamines, e.g. serotonin and noradrenaline. There is, therefore, diverse therapeutic potential for... 

Nitric oxide Endogenous vasodilator released from vascular endothelium neurotransmit-... 

Endogenous antipyretics include certain cytokines, neuropeptides, glucocorticoids, hormones, nitric oxide, and others. 

Hughes, S.R., Williams, T.J. and Brain, S.D. (1990). Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. Eur. J. Pharmacol. 191, 481-484. 

Pique, J.M., Tepperman, B.L., Esplugues, J.V. and Whittle, B.J.R (1990). Involvement of endogenous nitric oxide, an endothelium-derived vasodilator, in the regulation of gastric mucosal blood flow. Gastroenterology 98, A196. 

Hosoki R, Matsuki N, Kimura H. 1997. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237 527-531. 

Datta, S., Patterson, E. H. Siwek, D. F. (1997). Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep. Synapse 27, 69-78. 

Hars, B. (1999). Endogenous nitric oxide in the rat pons promotes sleep. Brain Res. 816, 209-19. 

N.R. Ferreira, A. Ledo, J.G. Frade, G.A. Gerhardt, J. Laranjinha, and R.M. Barbosa, Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes. Anal. Chim. Acta 535, 1—7 (2005). 

G.B. Stefano, W. Zhu, P. Cadet, T.V. Bilfinger, and K. Mantione, Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the mu 3 opiate receptor subtype a hormonal role for endogenous morphine. J. Physiol. Pharmacol. 55, 279-288 (2004). 

B. Beltran, M. Quintero, E. Garcia-Zaragoza, E. O Connor, J.V. Esplugues, and S. Moncada, Inhibition of mitochondrial respiration by endogenous nitric oxide a critical step in Fas signaling. Proc. Natl. Acad. Sci. U.S.A. 99, 8892 (2002). 

The role of CuZnSOD on oxygen radical production in cerebral vessels has been studied. Didion et al. [28] demonstrated that endogenous CuZnSOD diminished superoxide levels in rabbit cerebral blood vessels and affected nitric oxide- and cyclooxygenase-mediated responses in cerebral microcirculation. A subsequent study by the same group [29] showed increased superoxide production and vascular dysfunction in CuZnSOD-deficient mice. Chang et al. [30] suggested that superoxide induced cytokines, which activated microglial... 

Endogenous NO is produced almost exclusively by L-arginine catabolism to L-citrul-line in a reaction catalyzed by a family of nitric oxide synthases (NOSs) [3]. In the first step, Arg is hydroxylated to an enzyme-bound intermediate "-hydroxy-1.-arginine (NHA), and 1 mol of NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) and O2 are consumed. In the second step, N H A is oxidized to citrulline and NO, with consumption of 0.5 mol of NADPH and 1 mol of 02 (Scheme 1.1). Oxygen activation in both steps is carried out by the enzyme-bound heme, which derives electrons from NADPH. Mammalian NOS consists of an N-terminal oxy-... 

Endogenous nitric oxide plays an important role as a messenger between neurons at synapses in the central nervous system [11] and fulfills the major... 

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